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What is Vivaglobin?
Vivaglobin, a sterile solution made of human plasma, is a sterile solution. It contains antibodies that help the body fight off infections from different diseases.
Vivaglobin is used to treat primary immunodeficiency. This includes but is not limited to the primary immunodeficiency of common variable immunodeficiency, X-linked agammaglobulinemia (CVID), congenital agammaglobulinemia, and Wiskott-Aldrich syndrome.Vivaglobin can be used in other ways not mentioned in this guide.
Warnings
If you have hyperprolinemia (high levels of a specific amino acid in your blood), then you should avoid using Vivaglobin.
Vivaglobin may cause blood clots. Blood clots are more likely to occur if there are risk factors, such as heart disease or blood circulation problems. If you use estrogen, have a blood clot history, are over 65, have been bedridden, or are using a cath, you may also be at greater risk.
If you experience any of the following symptoms, stop using Vivaglobin immediately and contact your doctor.
- Signs of a brain blood clot: sudden numbness, weakness or slurred words (especially on one side), problems with vision and balance
- Signs of a blood clot in your heart or lung: chest pain, rapid heartbeat, sudden coughing, wheezing, or rapid breathing;
- Signs of a blood clot on your leg include pain, swelling, warmth, or redness.
Vivaglobin may also damage your kidneys. This is especially true if you have kidney disease and/or use other medications. Other drugs, including some over-the-counter medicines, can also harm the kidneys.
If you notice any of the symptoms of a kidney disease, such as swelling, rapid growth in weight, or little or no urine, call your doctor immediately.
Drink lots of fluids when using Vivaglobin. This will help to improve blood flow and ensure that your kidneys are working correctly.
Similar/related drugs
Hizentra, Octagam, Privigen, Gamunex-C, immune globulin intravenous, and Cuvitru
Before you take this drug
If you've ever had an allergy reaction to immune globulins, or if:
- Immune globulin A deficiency (iga), with antibodies to iga
- Hyperprolinemia is a condition characterized by a high blood level of an amino acid.
Immune globulins can cause blood clots and kidney damage. Tell your doctor if:
- Heart disease is characterized by problems with blood circulation or blood vessel disorders.
- A history of strokes or blood clots;
- If you are using oestrogens (birth-control pills or hormone therapy),
- Kidney disease
- Diabetes;
- If you are dehydrated,
- If you are 65 or older,
- If you are bedridden because of a severe illness,
- If you use a catheter,
If you have been exposed to measles or traveled to an area with a high prevalence of this disease, you may need to adjust your dose.
FDA pregnancy category C There is no information on whether Vivaglobin can harm an unborn child. If you plan to get pregnant or are already pregnant, tell your doctor.Immune globulin does not pass into breast milk. It is also unknown if it can harm a baby who is nursing. You should tell your doctor if a child is breastfed.
Vivaglobin (a component of human blood plasma) may contain viruses or other infectious agents. Plasma donated is treated and tested to reduce the possibility of it being infected, but it is still possible that it could spread disease. Speak to your doctor about the benefits and risks of using Vivaglobin.
How to take Vivaglobin?
Vivaglobin subcutaneously is injected using an infusion pump. A catheter is placed under the skin to allow the medicine to enter your body. You may be taught how to inject at home. Self-injecting Vivaglobin is not recommended if you are not sure how to properly give an injection or dispose of needles, tubing, and other items that were used to inject this medicine.
Vivaglobin should be taken once a week. Dosage instructions from your doctor should be followed. Keep a journal if you are using this medication at home. Record the dates, times, and places you have injected the medicine.
Vivaglobin should be administered slowly. The infusion may take up to an hour. This medicine may require up to four catheters at once to be injected into different areas of the body. Your healthcare provider will show you the best areas of your body where you can inject the medicine. You should follow your doctor's directions.
Shaking the bottle can ruin the medicine. Do not prepare your dose until you are ready for an injection. Do not mix Vivaglobin with other medications within the same infusion. If the medication has changed color or contains particles, do not use it. For new medication, call your pharmacist.Vivaglobin should not be injected into a vein.
Test the infusion pump to ensure that the needle is not stuck in a vein before injecting medicine. Pull back the plunger on the syringe attached to the infusion tubule. Remove the catheter and tubing if blood is flowing back into the syringe. Try again with a fresh catheter and syringe. Insert the needle at a different location on your body and check for blood flow.
Each Vivaglobin single-use bottle (vial) is only for one use. After one use, throw away the vial (bottle), even if some medicine is left.Only use disposable injection items once (a needle or catheter). Ask your pharmacist how you can dispose of the puncture-proof container. This container should be kept out of the reach of pets and children.
You may need to have frequent blood tests while using Vivaglobin.This medication may cause abnormal results in certain medical tests. Inform any doctor that you see about your use of Vivaglobin.
Store Vivaglobin at 2–8 °C (36–46 °F) in the original carton. Store in the fridge at 2–8 °C.Avoid freezing. Any immune globulin that has frozen should be thrown away. Allow the medicine to come to room temperature before you prepare your dose.
After the expiration date, throw away any unused Vivaglobin.
What happens if I miss the dose?
If you forget to take a dose, call your doctor.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Avoid receiving a "live vaccine" while using Vivaglobin. During this period, the vaccine may not be as effective, and you may not receive full protection from disease. Live vaccines are available for measles (MMR), rubella, typhoid (Yellow Fever), varicella (chickenpox), zika (shingles), and influenza (nasal flu).
Side effects of Vivaglobin
If you experience any of the following symptoms of an allergic reaction, seek emergency medical attention: hives, wheezing or difficulty breathing, dizziness, feeling as if you could pass out, or swelling of your lips, face, tongue, or throat.
If you experience any of the following symptoms, stop using Vivaglobin immediately and contact your doctor.
- Signs of a brain blood clot: sudden numbness, weakness or slurred words (especially on one side), problems with vision and balance
- Signs of a blood clot in your heart or lung: chest pain, rapid heartbeat, sudden cough, wheezing, and rapid breathing;
- Signs of a blood clot in the leg: pain, swelling, warmth, or redness on one or both legs
- Signs of kidney problems: swelling, rapid weight gain, and no or little urination;
- Liver problems: fast heartbeat, fatigue, dark urine, and jaundice
- Blue lips, pale or blue-coloured fingers or toes, chest pain, difficulty breathing, or
- Signs of a new infection: high fever; flu symptoms; mouth sores; severe headache; neck stiffness. Increased sensitivity to the light.
Vivaglobin may cause side effects such as:
- Redness, swelling, itching, and bruising where the medicine has been injected
- Nausea, vomiting, diarrhea, bloating, and stomach pain;
- Headache, fatigue, and headaches
- Itching and rash that is mild
- Back pain is a common complaint.
- You can experience pain in any part of your body.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Vivaglobin may harm your kidneys. This effect can be increased if you use other medications, such as antivirals (antiviral drugs), chemotherapy, injected bacteria, medicine for bowel problems, medicine to prevent rejection of organ transplants, injectable osteoporosis medicine, or some pain relievers and arthritis medications.
Other drugs, such as prescription and over-the-counter medicines, herbal products, vitamins, and herbal supplements, may interact with immunoglobulin. Inform your healthcare providers of all the medicines you are taking and those you plan to take.