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Generic name: immune globulin (subcutaneous) [im-MYOON-GLOB-yoo-lin]
Drug class: immune globulins

What is Hizentra?

Hizentra can be described as a sterilized product composed of human plasma. It is a source of antibodies that aid your body in protecting itself from infections caused by different diseases. Hizentra subcutaneous injection (for subcutaneous injection) is used to treat primary immune deficiency conditions. This can include, however, the defect in the humoral immune system in congenital agammaglobulinemia. Common variable immunodeficiency (CII), X-linked agammaglobul Wiskott-Aldrich syndrome, and severe combined immunodeficiencies Hizentra can also be used to treat chronic inflammation and demyelinating polyneuropathy (an autoimmune disorder that occurs when an immune system attacks nerves that cause weakness in muscles and numbness).


Hizentra may cause serious reactions to allergies, kidney failure, liver issues, and blood clots. The risk of developing blood clots is higher for older people or those who have suffered from blood clots, heart issues, or blood circulation issues. The risk of blood clots is also higher likely to happen during bedrest for long periods and when using birth medication to control the condition and hormone therapy using an intravenous central (IV) catheter installed.Contact your doctor immediately. If you experience chest pain or breathing problems, rapid heartbeats, weakness or warmth, swelling, or discoloration of your leg or arm

This medication can affect the kidneys of your patients, especially if you have kidney problems or take certain medications. Talk to your doctor right away when you notice symptoms of kidney disease that include swelling, rapid weight gain, and a lack of urine.

Drink plenty of fluids while you're taking Hizentra to improve the flow of your blood and ensure that your kidneys are working effectively. You shouldn't take Hizentra when you have an illness known as hyperprolinemia (high levels of a specific amino acid in the blood).

Similar or related drugs

Azthioprine, Imuran, Octagam, Privigen, Betaseron, Hyqvia, and Gammagard Liquid

Before taking this medicine

It is not recommended to use Hizentra when:

  • You've experienced an allergic reaction due to an immune globulin, blood product, or other
  • You have insufficient antibodies to immunoglobulin A (IgA).

It is possible that you will not be able to take Hizentra if you've ever experienced any allergic reactions with polysorbate or if you suffer from an illness known as hyperprolinemia (high levels of a specific amino acid in the blood).

This medication can trigger kidney issues or blood clots, especially in older individuals or people suffering from particular conditions. To be sure Hizentra injection is suitable for you, inform your physician if you've ever suffered from:

  • Heart issues or blood circulation issues as well as "thick blood";
  • A blood clot or stroke;
  • Kidney disease;
  • Diabetes;
  • An infection known as sepsis
  • If you are using hormones (birth hormone control pills, hormone replacement therapy),
  • If you've been in bed for a long time,
  • If you have an intravenous central (iv) catheter installed,

It is possible to require an adjustment in dose if you have been exposed to measles or when you Avoid giving this medication to children without obtaining medical guidance.

Hizentra is produced from human plasma donated by donors and may be contaminated with infections or viruses. Plasma donated to the clinic is analyzed and treated to lower the risk of contamination; however, there is the possibility that it may carry diseases. Consult your physician about the danger.

How to take Hizentra?

Hizentra is injected beneath the skin by using an injection pump. The medication enters your body via a tube that is placed beneath the skin. The healthcare professional can teach you the proper use of the medication on your own. Hizentra may be administered each day, but it is also given every 1 or 2 weeks. Take this medicine frequently to maintain a constant amount of medication within your body throughout the day. If you take this medicine at home, you should keep notes of the dates and times you administered the injection, as well as where you administered it to your body.

Hizentra should be administered slowly. You might require up to eight different catheters in order to inject this medication into different body parts simultaneously. Your doctor will inform you where to inject Hizentra. You should use a different spot every time you administer an injection. Make sure you don't inject in the same spot twice in one row. Be sure to read and adhere to any instructions for use that are included in your medication. Consult your physician or pharmacist to clarify any instructions.

Make an injection only when you are prepared to administer it. Don't use the medicine if it becomes cloudy, changes color, or has particles. Consult your pharmacist about the latest medication. Don't shake the medicine bottle, or you could ruin the medicine. Avoid injecting Hizentra into veins. You'll require frequent blood tests. Hizentra may affect the results of some other medical tests you require. Be sure to inform any doctor who sees you that you're taking Hizentra.

Keep Hizentra in the original container at room temperature. Be sure to protect it from light and heat. You can also store this medicine in its original container in the fridge. Avoid freezing Hizentra, and then throw the medicine out when it becomes frozen. You must use your medication within a specified amount of time. It will be contingent on the method of storage (at ambient temperature or in the refrigerator). Follow the storage guidelines that are included in your prescription. Talk to your pharmacist if you have any questions. Get rid of any medicine that has not been used within the time limit printed on the bottle.

Every throughl (bottle) is intended for only one usage. Dispose of it after one use, regardless of whether there's a little medicine inside.

Utilize disposable injection devices (needle catheters, tubing, etc.) only once and then put them in a punctureproof "sharps" container. Be sure to follow the laws of your state or city on the disposal of the container. Keep it out of the reach of pets and children.

Do I be concerned if I miss a dose?

Consult your physician for instructions when you have missed the dose.

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Do not get any "live" vaccines while using Hizentra. The vaccine might not work as effectively and could not be able to fully protect you against diseases. The live vaccines are measles, rubella, and mumps (MMR), as well as rotavirus, yellow fever, typhoid varicella (chickenpox), shingles, and nasal influenza (influenza).

Side effects of Hizentra

Stop using the medicine and seek emergency medical assistance. If you show symptoms that indicate an allergy reaction, Hizentra: hives wheezing; chest tightness; difficulty breathing; nausea and feeling as if you could pass out; swelling on your lips, face, or tongue.

See your doctor right away in the event that you are suffering from:

  • A condition of the blood cells that causes yellow or pale skin or dark-colored urine, anxiety, confusion, or fever;
  • Kidney issues The result is a lack of or very little urine, swelling, a fast increase in weight, and feeling tired of breath.
  • Lung issues chest pain, breathing problems blue-colored lips, fingers, or toes;
  • Indications of the onset of a new infection, such as fever, severe headache, neck stiffness, eye pain, and increased sensitivities to light.
  • Indications for a blood clot, shortness of breath, chest pain that is accompanied by deep breathing, a rapid heart rate, weakness or numbness on the opposite leg or side, swelling, and discomfort or discoloration on the leg or arm.

Common side effects associated with Hizentra include:

  • Trouble breathing or wheezing
  • Bleeding, redness, pan, swelling, itching, or a lump of hard substance where the medicine was injected.
  • Fever, tiredness, dizziness;
  • Nausea, vomiting, diarrhea, bloating, and stomach pain;
  • Itching the skin, rashes, or other skin issues;
  • Symptoms of the cold or flu, such as a stuffy nose, coughing, sore throat, cough, and stuffy nose;
  • Headache, migraine, or
  • Discomfort anywhere in your body.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Immune globulin is a risk to the kidneys, especially when you are also taking certain medications to treat cancer, infections, osteoporosis, organ rejection of a transplant, bowel diseases, high blood pressure, or arthritis pain (including Advil, Motrin, and Aleve).

Other drugs can interfere with immune globulin, which includes prescription and over-the-counter medications, vitamins, and herbal supplements. Inform your physician about the medicines you are currently taking and any medication you begin or stop taking.