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Generic name: tioconazole vaginal [tee-oh-CON-a-zole]

Brand names: 1-Day, Vagistat-1
Drug class: vaginal anti-infectives

What is Vagistat-1?

Tioconazole is an antifungal medicine that combats the effects of the fungus.Vagistat-1 (for use in the vagina) is a treatment for vaginal Candida (yeast) infections.Vagistat-1 is also used for different purposes not covered in this guideline.

Side effects of Vagistat-1

Contact a medical professional immediately. If you experience any of the following symptoms that indicate reactions to an allergen: hives; trouble breathing or swelling of your lips, face, tongue, throat, or face

Contact your doctor immediately if you notice any increase or worsening of vaginal symptoms.

Common adverse effects of Vagistat-1 could include:

  • Vaginal redness, swelling
  • Mild stomach pains;
  • Burning or pain during urination;
  • Headache running or stuffy nose
  • Minor vaginal burning, itching, or irritation following use.

This list does not represent all possible side effects; others could occur. Please consult your physician if experiencing adverse reactions and report them immediately to FDA at 1-800-FDA-1088.


Follow the directions on your prescription label and on the label of your package. Be sure to inform your healthcare professionals about your medical ailments and allergies, as well as any medications you take.

Similar/related drugs

Fluconazole , Topical nystatin , clotrimazole topical , Diflucan , itraconazole , miconazole topical

Before you take this drug

It is not recommended to make use of Vagistat-1 in case you have an allergy to it.Don't take Vagistat-1 if you haven't suffered from any vaginal yeast infection that has been confirmed by a physician.

Speak with a pharmacist or doctor to determine if it's safe to take this medication in case you suffer from any other medical issues, particularly:

  • Fever, colds, nausea, and discomfort in your shoulder or back;
  • Vaginal discharge; pelvic pain with an unpleasant odor;
  • If you're experiencing vaginal itching or discomfort for the first time,
  • If you suspect you might be exposed to HIV (human immunodeficiency virus),

The FDA classification for pregnant women is C. It's not clear whether Vagistat-1 could harm an unborn baby. Do not take this medication without the advice of your physician, in case you are expecting.

It isn't known if the vaginal form of tioconazole enters breast milk or could cause harm to a nursing infant. Do not take this medicine without a physician's guidance if you're nursing.Avoid giving this medicine to anyone younger than 12 years old without medical assistance.

How to take Vagistat-1?

Take exactly as indicated on the label or as directed by your physician. Don't use in greater than smaller quantities or for longer periods than suggested.Do not consume Vagistat-1 through the mouth. It's only intended for use within your vagina.The medication comes with instructions to ensure safe and efficient use. Follow these guidelines carefully. Talk to your pharmacist or doctor if you have any concerns.

This medication is typically administered in one dose. There should be a slight improvement in your symptoms following the one-day treatment. It could take up to 7 days after taking the dose for a day before your symptoms disappear completely.

Contact your physician if your symptoms don't improve after three days or if you continue to experience symptoms for more than seven days. Infrequent vaginal yeast infections that are not cured with treatment could be an indication that you have a serious problem.The applicator for single-use is intended only for one usage. Dispose of the applicator after a single use, regardless of whether there is still some medication left within it following the insertion of the dose.

Vagistat-1 has mineral oils, also known as petrolatum, which may affect the latex rubber used inside a diaphragm or condom. These kinds of contraceptives could be less effective if used in conjunction with this medication. You should use a different method of birth control when you're taking tioconazole for a minimum of 3 days following the end of your treatment.Keep it at room temperature, far from heat and moisture. Do not heat the applicator prior to using Vagistat-1.

What happens if I miss the dose?

Because Vagistat-1 is one dose, it doesn't require a daily dose schedule.

What happens if I overdose?

Because Vagistat-1 is taken as a single dose using an applicator that is prefilled An overdose is highly unlikely to occur.

What should be avoided?

Avoid wearing tight-fitting synthetic clothing like pantyhose or nylon underwear, which do not permit air circulation. Wear loose-fitting clothing that is made of cotton or various other fibers that are natural until the inflammation is gone.

Don't use a vaginal douche, spermicide, or any other vaginal product while you're taking Vagistat-1. Avoid vaginal sexual contact while you are taking treatment.

Interaction with other drugs

It's unlikely that other drugs you consume orally will affect vaginal tioconazole. However, many drugs interact with each other. Be sure to inform your health care providers about the medications you take, including medications that are prescribed and available over the counter, vitamins, and herbs.