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Generical name: homatropine ophthalmic (also known as hoe-ma-TROE-peen”).
Names of brands: Homatropaire, Isopto Homatropine
Drug class: Mydriatics

What is Homatropaire?

Homatropine helps relax the muscles within the eye's iris (the colored area) of your eyes. Relaxing these muscles will help dilate or expand your pupils.

Homatropaire (for the eyes) is used to treat an eye problem known as uveitis. Homatropaire also helps to dilate the pupil prior to an eye exam or to decrease pressure in the eye after eye surgical procedures. Homatropaire can also be employed for other purposes that are not covered in this medication guide.

Side effects of Homatropaire

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, like hives, trouble breathing, and swelling of your lips, face, and tongue.

While the chance of suffering serious effects from side reactions is very low when homatropine is administered to the eyes, adverse reactions could occur if the drug is absorbed into the bloodstream.

Homatropaire may cause serious side effects. Contact your physician immediately in the event that you experience:

  • Eye swelling or redness, the formation of a crust, or drainage
  • Eyelids that are puffy or red
  • Disorientation, agitation, or
  • Strange thoughts or behaviors.

Common negative side effects of Homatropaire could include:

  • Burning and stinging after using drops for the eyes;
  • Dry mouth and increased thirst
  • Increased sensitiveness of your eyes to the light.

This isn't a complete list of possible side effects, and other side effects could be present. Consult your physician to seek medical advice on the effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

Dexamethasone, an ophthalmic medication; triamcinolone, an ophthalmic Humira, Azthioprine, Atropine Eye, Ophthalmic cyclopentolate, Homatropine ophthalmic


You shouldn't take Homatropaire when you suffer from the condition of glaucoma.

Before taking this medication,

This medication if you have an allergy to homatropine or you are:

  • glaucoma, or
  • If your eye doctor observes any changes within your eyes that could indicate glaucoma, it's time to get checked.

It isn't known if this medicine can affect a newborn baby. Consult your physician if you are expecting.

It is not clear if the ophthalmic homatropine is absorbed into breast milk or whether it can harm the nursing infant. Inform your doctor if you are breastfeeding a baby.

How to take Homatropaire?

Follow the directions on the label of your prescription. Don't use Homatropaire in greater or less quantities or for longer periods than suggested.

Use caution when using this medication when wearing contact lenses. Homatropaire could contain a preservative that can cause the discoloration of soft contact lenses. You should wait at least 15 minutes after taking the medicine before putting in contacts.

In order to treat uveitis, you might need to apply Homatropaire at least every 3–4 hours.

Wash your hands thoroughly prior to applying drop drops to your eyes.

To apply drops to the eyes:

  • Adjust your head slightly and then pull the lower eyelid, creating a tiny pocket. Keep the dropper in front of the eye, with the tip facing down. Take a look towards the sky to the side away from where you are holding it, and squeeze one drop.
  • You can close your eyes for two or three minutes with your head down without blinking or squinting. Press your finger gently to the inner corner of your eye for around one minute to stop the liquid from leaking into the tear duct.
  • Make sure you only use the amount of drops your doctor has advised. If you are using several drops at once, you should wait at least five minutes in between each drop.
  • Take at least 10 minutes prior to applying or using any eye drop or other that your medical professional has advised you to use.

Do not touch the edge of your eyedropper or put the dropper directly onto your eyes. A dropper that is contaminated could affect your eyes and cause serious vision problems.

Don't use eye drops if the solution is changing color or has particles within it. Consult your pharmacist about new medications.

Keep it at room temperature, free of heat and moisture. Avoid freezing. Make sure the bottle is tightly sealed when not being used.

Do I be concerned if I miss a dose?

Do the missed dose immediately after you remember. Don't miss any missed dosages if it's nearing the time to take the next dose. Do not take any extra medicine to make up for the missed dose.

What will happen if I take excessively?

For medical emergencies, seek emergency treatment or contact the Poison Help Line at 1-800-222-1222 in the event that anyone has swallowed the medicine accidentally.

What should be avoided?

Homatropaire can cause blurred vision and affect your thinking or reactions. Be aware when you drive or engage in any activity that requires that you be aware and capable of seeing clearly.

Homatropaire can cause your eyes to be more sensitive to sunlight. Be sure to protect your eyes when you are out in the sun.

Interaction with other drugs

It's not likely that other medications you take in the form of injections or orally can affect the homatropine in your eyes. However, many medications can interact with each other. Inform your healthcare professionals about all medicines you are taking, such as prescription and non-prescription medicines, vitamins, and herbal remedies.