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Aflibercept Eye Drops

Generic Name: Aflibercept ophthalmic [a-FLIB-er-sept-off-THAL-mik]                                            Brand Names: Eylea, Eylea Pre-filled Syringe.
Dosage Format: Intravitreal solution (40 mg/mL).
The Class of Drug: Anti-angiogenic ophthalmic agents.

What is Aflibercept?

Aflibercept Ophthalmic (for the eye) medicine helps treat age-related wet macular degeneration. Aflibercept is also employed to manage macular edema caused by retinal vein obstruction, which is a swelling of the retina due to obstruction of blood vessels.

Aflibercept Ophthalmic is also utilized in the treatment of diabetic retinal disease, which is an eye condition for diabetics that may cause a buildup of liquid in the retina, which can result in blindness. Aflibercept is also utilized to treat macular edema due to diabetes, which is a buildup of retinal fluid that results from the leakage of blood vessels.

Aflibercept can also be utilized to manage prematurity retinopathy, which is an eye disorder that affects premature infants' retinas. Aflibercept ophthalmic can also be used for reasons not mentioned in this guideline.

Side Effects of Aflibercept eye drops

Get immediate medical attention. If you are experiencing symptoms that are warning signs of an allergic reaction, like hives, trouble breathing, or swelling of your face, eyes, lips, tongue, or throat,

Aflibercept ophthalmic can cause severe adverse reactions. Contact your doctor immediately in the event that you suffer from:

  • Eyes, or redness or inflammation around the eyes.
  • Sudden vision problems.
  • You see flashes of light as well as "floaters" in your vision; you can see halos in light.
  • Your eyes could become more sensitive to the light.
  • Chest pain.
  • A sudden weakness or numbness, especially on one side of the body.
  • Abruptly intense headache that is sudden, severe, and causes confusion. It can also cause issues with speech or balance.

Adverse Effects:

  • Watery or red eyes.
  • Blurred vision.
  • Eyelids swelling.
  • Slight eye pain or achy sensation after the injection.

This is not a complete list of all the side effects. Other effects may also be present. Contact your doctor to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Warnings

It is best not to use aflibercept in the event of swelling within your eye or any other type of inflammation within or around your eyes.

Contact your doctor immediately. If you experience eye redness, pain, or swelling in your eye area, or if you experience sudden issues with your vision at any time while you are receiving treatment,

Before you take this drug

It is not recommended to use aflibercept if you are allergic to the substance or are suffering from

  • The swelling in your eyes swelling in your eyes.
  • Any type of illness (bacterial or fungal) within or around your eyes.
  • A blood clot or stroke.
  • Glaucoma or any other condition that can increase pressure in your eyes.

Inform your doctor if you're to become pregnant. Utilize the most effective methods of contraception to avoid the possibility of becoming pregnant before the first dose of aflibercept, an ophthalmic. Use the birth control during treatment and for at least three months after the last injection. Do not breastfeed.

How to take aflibercept eye drops?

Aflibercept ophthalmic is an injection into your eye. Your doctor will inject the medicine to reduce the pain in your eyes prior to giving you the injection. The injection will be administered at your doctor's clinic or at a different clinic.

After a brief period following the injection, the eyelids will be examined regularly to ensure the injection did not cause any adverse effects.

Aflibercept can be administered at different intervals based on the condition being treated by the medication. Follow the instructions of your doctor for dosage extremely carefully.

Details on dosage

Usual Adult Dose for Macular Degeneration:

2 mg intravitreal injections every four weeks during the initial 12 weeks. after which 2 mg intravitreal injections are given every 8 weeks.
Some patients might need to continue their daily 4-week dosing for the initial 12 weeks.
Comments:
Patients must be assessed on a regular routine.
The efficacy of the supplement was not proven in the majority of patients who were administered every 4 weeks as compared to once every 8 weeks; however, certain patients might require monthly dosing.
If you have had one year of effective treatment, patients could be treated with a dose of 2 mg by intravitreal injections every 12 weeks. However, this approach isn't nearly as efficient as the suggested daily dosing schedule of 8 weeks.
Use: To treat of the neovascular (wet) age-related macular degeneration.

Usual Adult Dose for Macular Edema:

Macular Edema due to Retinal Vein Occlusion (RVO):
2 mg via intravitreal injection every 4 weeks
Diabetic Macular Edema ( DME):
2 mg intravitreal injections every four weeks during the initial five shots (20 weeks) Then 2 mg intravitreal injections every 8 weeks.
Some patients might need to continue their daily 4-week dosing for the first 20 weeks.
Diabetic Retinopathy (DR):
2 mg intravitreal injections every four weeks during the initial five shots (20 weeks) Then 2 mg intravitreal injections every 8 weeks.
Some patients might need to continue their daily 4-week dosing for the first 20 weeks.
Comments:
Patients must be evaluated on a regular basis.
The efficacy of the supplement was not proven for the majority of patients when dosages were every 4 weeks as opposed to every 8 weeks; however, certain patients might require monthly doses.
Uses: To treat macular edema resulting from retinal vein occlusions, diabetic macular edema and diabetic retinal disease.

What happens if I miss a dose?

Consult your physician for treatment in the event that you don't make an appointment to receive the injection of aflibercept.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Aflibercept ophthalmic can cause blurred vision and could decrease your reaction. Avoid driving or engaging in hazardous activities until you understand the effects of this medication on your vision.

Interaction with other drugs

Eye medicine will not be affected by other medicines that you are taking. However, many medications can interact with each other. Be sure to inform your health care providers about the medications you are taking, which include prescription and non-prescription medicines, vitamins, and herbal remedies.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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