What is agalsidase beta?
Agalsidase beta is a treatment for Fabry's disease (a deficiency of the alpha-galactosidase A enzyme) for both children and adults aged 2 or more years. Agalsidase beta could be used for reasons that are not listed here.
Side Effects of Agalsidase Beta
Contact a medical professional immediately. If you show symptoms that indicate an allergy,
- Wheezing and chest tightness; difficulty breathing; feeling lightheaded.
- Skin eruption that causes hives, a skin rash, or flushing (warm redness or a tingly sensation).
- Difficulty swallowing.
- Swelling of your lips, tongue, or face.
Certain side effects can occur during an injection. Inform your doctor immediately if you experience any of the following symptoms of an
Adverse Effects:
- Chest discomfort, tightness in your throat, slow or fast heartbeats, pounding in your neck or ear;
- Breath shortness and stuffy nose sensation of being hot and frigid;
- Tiredness, dizziness, feeling like you are about to pass out;
- Itching, itching, sensation of tingling or numbness;
- Nausea, vomiting, stomach pain, diarrhea,
- headache, muscle pain, or swelling in your feet or hands.
- Fever, chills, cough;
- Dizziness;
- Swelling of your feet or hands
- Tingling or numbness;
- Fatigue;
- It can be a rash.
- Symptoms like nasal stuffiness, sneezing, and a sore throat.
This isn't a complete list of possible side effects, and others could happen. Contact your doctor to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.
Warnings
A lot of people experience a serious reaction to agalsidase beta. Tell your caregiver when you experience an allergic skin reaction, hives and chills, fever or headaches, muscular pain or dizziness, nausea, numbness, and chest pain, diarrhea, difficulty breathing or swallowing, a rapid and moderate heartbeat, or extreme dizziness.
Before you take this drug
Inform your doctor if you were ever diagnosed with:
- Heart conditions heart problems
- An allergy to agalsidase beta or are allergic to the medication.
Consult your doctor if you are nursing or pregnant. Your name might be listed on the Fabry patient registry. This will help track the progression of your illness and also assess the therapeutic effects of Agalsidase Beta. Participating in this registration is particularly essential if you're breastfeeding or pregnant.
How to take agalsidase beta?
Agalsidase beta is injected into the vein by a medical practitioner and is usually administered every two weeks. Doses are determined by weight. Your dose may change if you gain or lose weight. It is possible that you will require regular medical tests.
Details on Dosage
Usual Adult Dose for Fabry Disease:
1 mg/kg via IV infusion every 2 weeks
INFUSION RATE: The rate of infusion should be less than 0.25 mg/min (15 mg/hr). Once tolerance to infusion has been established, it may be possible to increase infusion rates in steps between 0.05 and 0.08 mg/min for each successive infusion.
Maximum rate of infusion (weight less than 30kg): 0.25 mg/minute
The minimum infusion length (weight of 30kg or more) is 1.5 hours (based on the individual patient's tolerance).
Comments:
Antipyretics are advised prior to infusions. Antihistamines are also recommended for patients who have suffered from an infusion-related reaction.
If you have a positive skin test, check out the dosage adjustment for the administration of a challenge.
Use: To treat patients who have been diagnosed with Fabry disease.
Usual Pediatric Dose for Fabry Disease:
2 years old or older:
1 mg/kg via IV infusion every 2 weeks
INFUSION RATE: The initial rate of infusion should be less than 0.25 mg/min (15 mg/hr). After tolerance to the infusion has been established, it is possible to increase the infusion rate by intervals between 0.05 and 0.08 mg/min for each successive infusion.
Maximum rate of infusion (weight less than 30 kilograms): 0.25 mg/minute
Minimum duration of infusion (weight of 30kg or more): 1.5 hours (based on the individual patient's tolerance)
Comments:
Antipyretics are advised prior to infusions. Antihistamines are recommended for patients who have suffered from an infusion-related reaction.
If you have a positive skin test, check out the section on dose adjustment for the rechallenge procedure.
Use: To treat patients aged 2 or over with a confirmed Fabry disease.
What happens if I miss a dose?
Consult your physician for the proper procedure. If you do not show up to get your injection.
What happens if I overdose?
In a medical facility, an overdose could be taken care of quickly.
What should be avoided?
Follow the doctor's advice regarding any limitations on foods, drinks, or any activity.
Interaction with other drugs
Other drugs can also influence agalsidase beta, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor about any other medications you take.
