What is Talzenna?
Talzenna (talazoparib) is used to treat certain kinds of breast cancer as well as prostate cancer. Talzenna is effective in stopping or reducing the growth of cancerous cells. Talzenna is part of a class of medicines known as PARP inhibitors, which is the widely used term to refer to poly (ADP-ribose) polymerase (PARP) inhibitors.
Talzenna can be used for treating breast cancer in people with a deleterious germline mutation of BRCA (gBRCAm) who are non-HER2-positive and who are locally in an advanced stage or have spread to different areas of the body. Talzenna is used in combination with enzalutamide (Xtandi) to treat adults with prostate cancer that is HRR gene-mutated and metastatic castration-resistant. Your doctor will examine the type of tumour to be certain that Talzenna is the appropriate treatment for you. Talzenna was approved for the first time by the FDA on October 16th, 2018.
Warnings
Utilising Talzenna can increase your chances of developing bone marrow disorders as well as leukaemia. Talzenna may lower blood cell counts. This means that you could contract infections or be more prone to bleeding. Consult your physician if you are experiencing unusual bleeding, bruising, blood in the stools or urine, weight loss, fever, fatigue, weakness, or breathing problems. The blood of your patient will be analysed prior to and during treatment, and cancer treatment may be delayed depending on the results.
Before you start taking this medicine
To be sure Talzenna is safe for you, ask your physician if you've previously had:
- Kidney disease.
The use of Talzenna can increase your chance of developing bone marrow disorders or leukemia. Talk to your doctor regarding your specific risk.
Pregnancy
Talzenna may cause harm to a baby who is not born if the mother or father are taking this medication.
- If you're a woman, you may need an ultrasound test to be sure that you're not pregnant. Take contraceptives during the course of this medication and for a minimum of 7 months following your last dose.
- If you're male, use birth control when your sex partner has the potential to become pregnant. Use birth control for at least four months after the last dose.
- Contact your doctor immediately in the event of a pregnancy.
It might be difficult for you to become pregnant when you are taking this medication. It is still recommended to use birth control to prevent pregnancies because this medicine could affect a newborn baby.
Breastfeeding
Do not breastfeed while taking this medication or for at least one month following the last dose.
Related drugs
Estradiol, Premarin, Arimidex, Xtandi, Zytiga, Femara, and Xeloda
How to take Talzenna?
Use Talzenna exactly as directed by your physician. Follow all instructions on the label of your prescription, and make sure you read all the instructions or medication guides. Your doctor may alter your dosage.
Talzenna capsules are typically consumed once per day, either in combination with food or not. Inhale the capsule completely and don't break or dissolve it. If you experience vomiting shortly after taking this medication, don't take a second dose. The next dose should be taken in the same manner as you were instructed. Do not alter your dosage or stop using this medication without consulting your physician. to the medication. It is possible to contract bleeding or infections more frequently. The blood of your patients will be examined in the course of treatment and before, and the treatment you receive for cancer could be delayed based on the results.
For prostate cancer treatment, Talzenna is used in conjunction with the drug enzalutamide (Xtandi). You should start or continue gonadotropin-releasing hormone (GnRH) analogue therapy during your treatment with Talzenna and enzalutamide unless you have had surgery to lower the amount of testosterone in your body (surgical castration).
Details on dosage
Usual Talzenna Adult Dose for Breast Cancer
Dose: 1 mg orally every day, up to development or unacceptably toxic.
Comment You should select patients on the basis of their germline BRCA mutations, as identified through an approved FDA test.
Utilisation: For the treatment of adults suffering from deleterious or suspecting deleterious germline mutations (gBRCAm) in HER2-negative local advanced or metastatic breast cancer.
Usual Talzenna Adult Dose for Prostate Cancer
Dosage: 0.5 mg taken by mouth daily, taken with enzalutamide. It can be taken until the progression of disease or toxicity is unacceptable.
Comment: The treatment is based on the presence of the HRR gene-mutated mCRPC.
Usage: For the treatment of adults suffering from homologous recombination repair (HRR) metastatic castration-resistant gene mutations. prostate cancer (mCRPC).
Talzenna capsules are available in 0.1 milligrammes, 0.25 mg, 0.35 mg, 0.5 mg, 0.75 mg, and 1 mg.
What happens If I miss a dose?
Do not miss the missed dose, and take your next dose at your regular time. Don't take two doses at the same time.
What happens if I overdose?
For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.
What should be avoided?
Follow the instructions of your physician regarding any limitations on foods, drinks, or any activity.
Side effects of Talzenna
Get immediate medical attention. If you are experiencing symptoms of an allergy reaction, Talzenna: hives, breathing difficulties, and swelling of your lips, face, and throat
Talzenna can cause serious adverse side effects.
Contact your doctor immediately. If you suffer from:
- The presence of blood in your urine or stools
- Simple bleeding, unusual bruising spots of red or purple under the skin
- Weight loss;
- Frequently infected;
- Low red blood cells (anemia), white skin, fatigue, feeling weak and lightheaded, shortness of breath, cold feet and hands,
- Low white blood cell counts (fever lips) sores, sores, coughing sores, cough.
The treatment you receive for cancer could be delayed or completely stopped when you experience certain adverse consequences.
Common Talzenna adverse effects could include
- Low blood cell count;
- The feeling of nausea, vomiting, diarrhea, and an inability to eat;
- Hair loss;
- Headache or
- Feeling tired or weak.
This isn't a complete list of all side effects, and other side effects could occur. Contact your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.
Interaction with other drugs
Discuss with your doctor all other medications, including:
- Amiodarone;
- Carvedilol;
- Clarithromycin;
- Itraconazole;
This list is not comprehensive. Other medications can be incompatible with talazoparib, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs, which are included here.
