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Loteprednol and tobramycin (ophthalmic)

Generic name: loteprednol and tobramycin (ophthalmic) [LOE-te-PRED-nol-and-TOE-bra-MYE-sin-off-THAL-mik]
Brand name: Zylet
Ophthalmic suspension (0.5%–0.3%)
Drug class: ophthalmic steroids containing anti-infectives

What is Loteprednol and tobramycin (ophthalmic)?

Loteprednol ophthalmic and tobramycin (for the eye) is a combination of antibiotics and steroids that is used to treat inflammation in the eye caused by allergies (herpes zoster), severe acne (iritis), uveitis (uveitis), eye injury (radiation), chemical burns, or other conditions.Loteprednol is prescribed when there is an increased risk of bacterial infections around or in the eye.This medication guide does not list all possible uses for loteprednol ophthalmic and tobramycin.

Side effects of Loteprednol and tobramycin (ophthalmic)

Seek immediate medical care if you have difficulty breathing, hives or swelling in the lips, face or throat.

Loteprednol or tobramycin can cause serious side effects. If you experience:

  • When using eye drops, you may experience severe pain or burning.
  • Tunnel vision and blurred vision are terms used to describe the phenomenon of seeing halos around light sources.
  • Pain behind your eyes, sudden vision changes;
  • Slow healing after eye surgery;
  • Signs of an eye infection include redness, discomfort, crusting, or drainage.

Some of the common side effects associated with loteprednol or tobramycin include:

  • Blurred vision
  • Minor burning or stinging.

There may be other side effects. For medical advice on side effects, call your doctor.To report adverse effects, you can contact the FDA at 1-800-FDA-1088.


If you have an infection in your eye (including Herpes Simplex), then loteprednol or tobramycin should be avoided.

Before you take this drug

This medicine should not be used if your eyes are infected with a viral or fungal infection (including herpes).

Inform your doctor if you experience any of these symptoms:

  • Glaucoma;
  • If you have cataracts or need cataract surgical treatment,

This medicine is not known to harm an unborn child. Inform your doctor if you are pregnant.Breast-feeding may not be possible while taking this medication. You should consult your doctor if you are concerned about any risks.

How to take Loteprednol and tobramycin (ophthalmic)?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Use only when wearing soft lenses. The lenses could be permanently stained by the preservatives in loteprednol or tobramycin. Use the medication at least 15 minutes prior to inserting your contacts.Before using eye medications, wash your hands.Before each use, shake the eye drops thoroughly.Use this medicine by tilting your head slightly back and pulling down your lower eyelid. Squeeze a few drops into the pocket created by holding the dropper over the eye. For a few minutes, close your eyes.Only use the prescribed number of drops.Do not touch the tip of the syringe or place it on your eyes. The contamination of the dropper can lead to serious eye problems.You may need to have frequent vision tests if you take this medication for more than 10 days.If your symptoms don't improve after two days of treatment, call your doctor.Do not suddenly stop taking this medication. You should follow your doctor's instructions regarding the dosage.Storing this medication upright at room temperature is recommended. Do not freeze.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed dose. Never take two doses of the same medicine at once.

What happens if I overdose?

Overdoses of tobramycin and loteprednol ophthalmic are not dangerous. If anyone accidentally swallows the medication, seek emergency medical attention. You can also call Poison Help at 1-800-222-1222.

What should be avoided?

Even if someone else has the same symptoms as you, do not share tobramycin or loteprednol with them.

Interaction with other drug

Other drugs that you take are unlikely to affect the medicine used on your eyes. Many drugs interact with each other. Inform your healthcare provider about the medicines you take, including vitamins and herbal remedies.