What is Sotorasib?
Adults with non-small-cell lung cancer can be treated with Sotorasib if they have been previously treated with a cancer drug.
Sotorasib can be given if the cancer has spread or progressed to other areas of the body or if surgery is not possible. You will be assessed by your doctor to determine the type of tumor that needs to be treated. This medication guide does not list all possible uses of Sotorasib.
Sotorasib side effects
If you experience any of the following signs and symptoms of an allergic reaction: hives; difficulty breathing; swelling in lips, face, tongue or throat. Seek medical assistance immediately.
Sotorasib can cause breathing problems, which could be fatal. Seek emergency medical attention if you develop a new or worsening cough or fever. Shortness of breath.
Sotorasib may cause serious side effects. If you experience:
- Severe ongoing nausea, vomiting, or diarrhea;
- Unusual bleeding: any bleeding that does not stop.
- Liver problems: loss of appetite, nausea, fatigue, itchiness, dark urine, clay-colored stools, and jaundice
If you experience certain side effects, your cancer treatment may be halted or delayed.
Sotorasib can cause the following side effects:
- Nausea, diarrhea;
- Cough;
- Liver problems
- Muscle, joint, or bone pain;
- Tiredness;
- Abnormal blood tests
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Opdivo, Rybrevant, methotrexate, cisplatin, Keytruda, Paclitaxel, and Avastin
Warnings
Do not use it other than as directed. Inform your doctor of any other medications you are taking or if you have allergies or other medical conditions.
Before you take this drug
Tell your doctor about any of the following:
- Liver disease
- Lung cancer is not the only cause of lung or breathing disorders.
There is no way to know if sotorasib can harm an unborn child. Inform your doctor immediately if you are pregnant, planning on becoming pregnant or considering becoming pregnant. Do not breastfeed for 1 week after the last dose of sotorasib.
How to take Sotorasib?
Read all instructions or guides that come with your medication and follow them carefully. Follow the directions on the label. Tests will be performed by your doctor to ensure that sotorasib treatment is right for you. Take sotorasib the same way every time, whether you take it with or without food. Sotorasib can be taken up to eight tablets per day. Take up to eight tablets to get your full dose. You should follow your doctor's advice.
Do not chew or crush the tablet. If you are unable to swallow the tablets, read and follow the instructions that come with your medicine. If you don't understand the instructions, talk with your pharmacist or doctor. Do not take another sotorasib dose if you vomit soon after taking it. Do not miss your next scheduled dose.
Take your sotorasib 4 hours or 10 hours before taking an antacid. Only use the antacid that your doctor has prescribed. You may be required to undergo medical tests in order to test your liver function. The results may change your medication or dose schedule. Store away from heat and moisture at room temperature.
Details on dosage
Adult dose for non-small cell lung cancer:
Orally, 960 mg once daily.
Duration of treatment: up until progression or unacceptable adverse side effects occur.
Comments:
This indication has been approved under an accelerated approval process based on the overall response rate and the duration of the response. Continued approval could be dependent on verification and description of clinical benefit through confirmatory trials.
Use: To treat patients with KRAS G12C mutations in locally advanced or metastatic non-small-cell lung cancer, as determined by FDA-approved tests, who have previously received at least one systemic treatment.
What happens if I miss the dose?
If you miss a dose by more than six hours, you should use the medication as soon as possible. Never take two doses of the same medicine at once. This could potentially have adverse consequences.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Ask your doctor about antacids, and only take the kind that your doctor prescribes.
Interaction with other drug
At times, taking different medications simultaneously may not be safe. Some drugs may affect the blood levels of drugs that you are taking, which can increase side effects and make them less effective.
Avoid taking antacids such as:
- Cimetidine, famotidine, nizatidine, ranitidine, Pepcid, Tagamet, and Zantac;
- Nexium, Prevacid, Prilosec, Protonix, and other brands
Sotorasib can be affected by other drugs, such as prescription and OTC medicines, vitamins, and herbal supplements. Inform your doctor of all medications you take.
