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What is Sonidegib?
Sonidegib can be used to treat basal cell carcinoma, a type of cancerous skin. Sonidegib can be given when radiation or surgery has failed to work or cannot be performed. Sonidegib can be used in other ways not mentioned in this guide.
Side effects of Sonidegib
If you experience any of the following signs and symptoms of an allergic reaction: hives, difficulty breathing, lip, face, tongue or throat swelling and/or difficulty swallowing
Sonidegib may cause kidney failure due to the breakdown of muscle tissue.
- Unexpected or severe muscle pain (even after stopping sonidegib);
- Little or no urinating is acceptable.
- Dark-coloured urine
Some of the side effects that sonidegib can cause include:
- Stomach pain, nausea, vomiting, and diarrhea;
- Loss of appetite Weight loss
- Tiredness;
- Itchiness of the skin; hair fall
- Changes in your sense of taste
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Fluorouracil topical, topical imiquimod, Efudex, Aldara, Cemiplimab, and Librato
Warnings
If the mother or father takes sonidegib during or at the time when conception occurs, it can cause serious birth defects. Men and women who use this medication should both use effective contraception in order to avoid pregnancy.
Women should not take sonidegib while pregnant. Use birth control to avoid pregnancy during the time you take this medication and for 20 months following your last dose. Use a condom if you're a man. Even if you had a vasectomy, you should always use one when having sex. Use condoms for the duration of your sonidegib treatment and at least eight months afterward.
Before you take this drug
Notify your doctor of any of the following conditions:
- Kidney disease
- A muscle disorder known as myopathy or rhabdomyolysis
Before you begin taking sonidegib, you will need a negative pregnancy result.
Sonidegib may cause serious birth defects if taken by the mother or father at the time conception occurs or during pregnancy. Men and women who use this medication should both use effective birth controls to avoid pregnancy.
- Women should not take sonidegib while pregnant. You should use effective birth control during the time you take this medication and for 20 months following your last dose. If you stop using birth control or your period is delayed, you should call your doctor immediately.
- Use a condom if you are a male when having sex with women who are pregnant or can become pregnant, despite a vasectomy. Use condoms for the duration of your sonidegib treatment and at least eight months afterward.
If you're a woman or a man and you think your contraception isn't working, call your doctor. Do not breastfeed if you are using this medication or for 20 months following your last dose.
How to take Sonidegib?
Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.
Sonidegib should be taken on an empty stomach at least one hour before or two hours after eating. Sonidegib will require frequent medical testing to ensure it does not have any harmful effects. These tests may delay your cancer treatment. Store away from heat and moisture at room temperature.
Sonidegib dosing information
Adult dose for basal cell carcinoma:
Take 200 mg once daily until the disease progresses or toxicity is unacceptable.
Comments:
Before starting therapy, creatinine kinase levels (CK) and renal function tests must be performed.
Verify the pregnancy status of all patients with reproductive potential.
Use: Adult patients with locally advanced basal carcinoma that has returned after surgery or radiotherapy or who are not candidates to undergo surgery or radiotherapy
What happens if I miss the dose?
If it is almost time for your next dose, skip the one you missed and go directly back on schedule. Never take two doses of the same medicine at once.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Don't donate blood while taking sonidegib. This should continue for at least twenty months after the last dose. Don't donate sperm (semen) if you are taking sonidegib or for 8 months following your last dose.
Interaction with other drug
Sometimes taking certain medications together may not be safe, as certain drugs could interfere with each other and increase side effects and decrease effectiveness. Sonidegib can be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are taking and those that you stop or start using.