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Sodium hyaluronate (injection)

Generic Name: Sodium hyaluronate (injection) [SO-dee-um-HYE-al-yoo-RON-ate] .

Brand Names: Durolane, Euflexxa, Gel-One, Gelsyn-3, GenVisc 850, etc. Show all 12 brands.
Dosage Form: Intraarticular Solutions of 10 mg/mL (16.8 mg/2 mL; 20 mg/mL).
Drug Class: Viscosupplementation agents.

What is Sodium hyaluronate?

Sodium hyaluronate is like the fluid that covers joints within your body. It acts as a lubricant as well as a shock absorber for joints.

Sodium hyaluronate can be used to relieve knee pain caused by osteoarthritis. Sodium hyaluronate can be prescribed in situations where different arthritis drugs haven't proved successful. Sodium hyaluronate can be used for other purposes that are not covered in this guide.

Side effects of Sodium hyaluronate

Contact a medical professional immediately. Get medical attention immediately if you notice warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue.

The sodium hyaluronate compound can cause serious adverse side effects. Consult your physician right away if you suffer from:

  • Significant swelling or pain around the knee area following the injection.

Common adverse effects of sodium hyaluronate could be:

  • Discomfort, pain, redness, stiffness, or puffiness in the area where the medication was injected.
  • Nausea, stomach pain.
  • Problems walking.
  • Swelling of your feet or hands.
  • Lower back pain, joint pain, muscle pain.
  • Sensation of tingling or numbness.
  • Headache, dizziness.
  • Nasal stuffiness or a sneezing sore throat.

This list does not cover every side effect possible with Levemir treatment. Other side effects could occur. Contact your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


It is not recommended to receive an injection of sodium hyaluronate when you are suffering from inflammation in your knees or the area of your knee's skin.

Before you take this drug

It is best not to receive sodium hyaluronate if you are allergic to it or if you are suffering from inflammation in your knee or the knee's skin. The sodium hyaluronate compound is not approved for use by anyone less than 21 years old.

Inform your doctor if you were ever diagnosed with:

  • Blood clots, circulation issues, or blood clots in your legs.
  • An allergy to feathers, birds, or eggs.

It is unclear if sodium hyaluronate harms the unborn baby. Consult your physician if you are expecting. It might not be safe to breastfeed a baby when you're taking this medication. consult with your physician about any possible risks.

How to take Sodium hyaluronate?

The sodium hyaluronate injection is directly into the knee joint. The healthcare professional will inject this drug. Sodium hyaluronate is typically administered once a week over three to five weeks. Follow the doctor's instructions for dosing with care. To avoid swelling and pain. Your doctor might suggest resting your knee or using ice to reduce swelling for a brief period after the injection. Take note of all information given to patients, including medication guides and instruction sheets. Consult your physician or pharmacist for assistance if you have concerns. Consult your physician if your symptoms don't improve or if they become worse.

 Details on dosage

Usual Adult Dose for Osteoarthritis:

Hyalgan: 2 mL of intra-articular injection into the knee every week for five weeks.
Supartz: 2.5 milliliters of intra-articular injections into the knee, once a week for five weeks.
Use: To treat osteoarthritis-related pain (OA) of the knee in patients who are unable to adequately respond to conventional non-pharmacologic treatment as well as simple analgesics (e.g., acetaminophen).

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to receive your sodium hyaluronate injection.

What happens if I overdose?

Because this medication is administered by a medical expert in a medical environment, the risk of overdose is less likely to occur.

What should be avoided?

At least for the first 48 hours following the injection, do not run or engage in strenuous activities, as well as high-impact sports such as tennis or soccer. Beware of weight-bearing activities and sitting for more than one hour at a time. Consult your physician about how long to rest before you can resume these activities.

Interaction with other drugs

Other medications can affect sodium hyaluronate. These include both prescription and over-the-counter medicines, vitamins, and herbal remedies. Discuss with your doctor the medicines you are currently taking as well as any medications you are about to start or stop taking.