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Generic name: tedizolid (oral/injection) [te-DIZ-oh-lid]

Drug class: Oxazolidinone antibiotics

What is Sivextro?

Sivextro, an antibacterial, is used to fight bacteria. Sivextro treats skin infections, such as "MRSA", in adults aged 12 and older. This medicine should be used only to treat infections caused by susceptible bacteria.


Only use Sivextro to treat bacterial infections. Tedizolid is not effective against viral infections, such as the common cold. Sivextro must be taken as prescribed, even if you feel better sooner in the course. If you skip doses or do not complete the entire course of treatment, it may reduce the effectiveness of your immediate treatment. It also increases the risk of bacteria developing resistance to the medication and making future treatments impossible.

Please carefully read all instructions printed on the label or package of your medication, and inform your healthcare provider of all medical conditions, allergies and medicines you are taking.

Before you take this drug

If you have an allergy to tedizolid, then Sivextro is not for you. Tell your doctor about any recent illness, including diarrhoea or a fever. Also, mention any cold or flu symptoms you may have experienced, such as a cough or swollen throat. Tell your doctor if diarrhoea has ever occurred while you were taking anti-biotics.

Tedizolid can harm an unborn child. Inform your doctor if you are pregnant. You may not be able to breastfeed while taking tedizolid. You should consult your doctor if you are concerned about any risks. Sivextro should not be used by anyone under the age of 12.

Similar/related drugs

Amoxicillin, Doxycycline, Ciprofloxacin, Cephalexin, Azthromycin, Metronidazole, and Augmentin

How to take Sivextro?

Follow the directions on your prescription label and read all medication guides or instructions sheets. Read all the instructions on the prescription label. Sivextro orally is taken by mouth. This medicine should be taken at the same time every day, whether or not you eat. An infusion of Sivextro is administered into a vein. Your healthcare provider may give you your first dose and teach you how to use the medication properly. Injections must be administered slowly, and infusions can take up to an hour.

Before using Sivextro, it must be mixed with a liquid. If you are using the injections yourself, make sure that you know how to mix and store them properly. Only use the diluent that comes with your medicine. Do not shake or agitate the medicine. Gently swirl it. If the colour of the medicine changes or if it contains particles, do not see it. For new medication, call your pharmacist. Even if you feel better quickly, continue to take this medication for the entire prescribed time. You can get an infection resistant to the medication if you skip doses. Tedizolid does not treat a virus, such as the flu or a cold.

Store Sivextro tablets away from moisture, heat, and other sources of heat. Do not take the tablet until you are ready. Only prepare your injection dose when you're ready to administer an injection. You can store the Sivextro injection mixture at room temperature for up to 24 hours or in the refrigerator.

Each single-use bottle (vial) of injection is only for one-time use. After one use, throw away the vial, even if it still contains medicine. Only use a needle or syringe once, and then store them in an "as sharps" container that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.

Details on dosage

Adult dose for skin and structure infections:

Take 200 mg intravenously or orally every day for six days.
Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-resistant and methicillin-susceptible isolates), Streptococcus pyogenes, S. Agalactiae, S. Anginosus group (including S. Anginosus, S. Intermedius, and S. Constellatus), and Enterococcus faecalis

The usual paediatric dose for skin and structure infections:

Twelve years and older: 200mg IV or orally, once daily for six days
Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of S. Aureus (including methicillin-resistant and methicillin-susceptible isolates), S. Pyogenes, S. Agalactiae, the S. Anginosus group (including S. Anginosus, S. Intermedius, and S. Constellatus), and E. Faecalis.

What happens if I miss the dose?

If you miss a dose, take it as soon as possible. Skip the missed dose when your next dose is less than eight hours away. Never take two doses in one go. Continue taking the medication every day, even if you miss a dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Antibiotics can cause diarrhoea. This could be an indication of a new illness. Call your doctor if you have bloody or watery diarrhoea before taking anti-diarrhoea medication.

Side effects of Sivextro

If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of your lips, face, tongue, or throat, contact emergency medical assistance immediately.

If you experience:

  • Severe stomach pain or diarrhoea that is bloody or watery (even months after the last dose);
  • Numbness or tingling
  • Severe headache, or pain behind the eyes.
  • Sores or white patches on the skin or in your mouth
  • Vaginal itching and discharge
  • Fast or pounding heartbeats
  • Low blood cell counts: fever, chills, and fatigue; easy bruising or bleeding; pale skin with cold hands and toes; feeling dizzy, light-headed, or short of breath.

Common Sivextro side effects may include:

  • Nausea, vomiting, diarrhoea;
  • Headache;
  • Dizziness;
  • Pain, swelling, bruising, or redness at the site of injection.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Interaction with other drug

Tell your doctor about your other medications, including:

  • Methotrexate;
  • Rosuvastatin (Crestor);
  • Topotecan.

This list is incomplete. Other drugs, such as vitamins and herbal products, may interact with tedizolid. This list does not include all drug interactions.