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Name of the generic: plazomicin [PLA-zoe MyE-sin]
Name of the brand: Zmdri
Dosage format: intravenous solution (50 mg/mL)
Drug class: aminoglycosides

What is Plazomicin?

The drug is called plazomicin, an antibiotic medicine that is used to treat severe infections of the kidneys or bladders. Plazomicin could cause serious or life-threatening adverse effects that might not be reverseable. Plazomicin should only be used for infections that can't be treated with a more effective antibiotic. Plazomicin can also be used for reasons not mentioned in this guideline.

Side effects of Plazomicin

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as difficulty breathing, hives, and swelling of your lips, face, and throat.

Plazomicin may cause kidney damage and can also result in nerve damage and the loss of hearing.

Consult your physician immediately if you suffer from:

  • Intense stomach pains; diarrhea that is bloody or watery (even if it's months after the previous dose);
  • Dizziness, spinning sensation;
  • A feeling of lightheadedness, as if you're passing out;
  • Hearing loss, buzzing or roaring sound that is heard in the ear (during or following the treatment of plazomicin)
  • Muscle weakness muscle weakness
  • Kidney issues: no or little urine output, swelling of your ankles and feet, fatigue, or feeling sluggish.

The risk of serious side effects is more frequent in older adults.

Common adverse effects of plazomicin could include:

  • Nausea, vomiting, diarrhea;
  • Headache or
  • Feeling lightheaded.

This isn't a complete list of possible side effects, and other side effects could be present. Consult your physician to seek medical advice on adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Similar or related drugs

Amoxicillin, Doxycycline, Ciprofloxacin, Augmentin, Levofloxacin, and Ceftriaxone


Plazomicin may affect your kidneys and could also cause hearing loss or nerve damage, especially if you suffer from kidney disease or take various other medications.

Before you start taking this medicine

You shouldn't use plazomicin when you have an allergy to plazomicin or other similar antibiotics, such as amikacin, gentamicin, kanamycin, Neomycin, streptomycin, or tobramycin.

Plazomicin is not a drug that has been approved for use by any person younger than 18 years of age.

Speak to your doctor if you were ever diagnosed with:

  • Kidney disease kidney disease
  • Disorders of the nerve, like myasthenia gravis.

Do not take plazomicin when you are expecting. This medicine may cause hearing loss in the new baby. Make sure you use effective contraception during pregnancy and tell your doctor if you are pregnant. It might not be safe to breastfeed while taking this medication. Consult your physician regarding any risks.

How to take Plazomicin?

Follow the instructions on the prescription label and review all medication guides and instructions sheets. Make sure you use the medicine exactly as prescribed. Plazomicin can be administered by infusion into the vein every 24–48 hours. The healthcare provider will provide the first dose and guide you on how to utilize the medication on your own.

Follow and carefully read any instructions for use that come along with your medication. Do not take plazomicin if you aren't familiar with all the instructions for use. Consult your physician or pharmacist if you have any concerns. Plazomicin is generally prescribed for a period of 4–7 days. Follow the doctor's instructions for dosing with care. Drink plenty of fluids when you take plazomicin. It is possible that you will require regular urine or blood tests. The kidneys, your hearing, and your nerve function could also require examination.

Place in the refrigerator and store Don't freeze. The contents of each bottle are intended for one-time use only. Dispose of it after one usage, even if there's still a little medicine inside.

Make use of a needle and syringe just once, and then put them in the punctureproof "sharps" container. Be sure to follow the laws of your state or city regarding how to dispose of the container. Keep it out of the reach of pets and children.

Details on dosage

Usual Adult Dose for Pyelonephritis:

15 mg/kg intravenous infusion (given over a period of 30 minutes) every 24 hours
The duration of treatment is between 4 and 7 days.

Comment: A suitable oral therapy is recommended after a period of 4–7 days of treatment in order to have a total (IV as well as oral) treatment time of 7–10 days.

Use: Treatment of complex urinary tract infections (cUTI), which include pyelonephritis due to susceptible strains such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae.

Usual Adult Dose for Urinary Tract Infection:

Infusion of 15 mg/kg (given over the course of 30 minutes) every 24 hours
The duration of therapy is between 4 and 7 days.

Comment: A suitable oral therapy is recommended after four to seven days of treatment in order to have a total (IV or oral) treatment period of 7–10 days.

Use: Treatment for complex urinary tract infections (cUTI) such as pyelonephritis, caused by tolerant strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae

Do I be concerned if I miss a dose?

Take the medication as quickly as you are able, but do not miss any missed doses if it's nearing time to take the next dose. Don't take two doses in one go.

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

The use of antibiotics can trigger diarrhea and could be a sign of a new illness. If you experience diarrhea that is swollen or bloody, consult your doctor prior to using antibiotics to treat diarrhea.

Interaction with other drugs

Plazomicin may affect your kidneys, especially in conjunction with specific medications for osteoporosis, cancer, or infections, organ transplant rejection, digestive issues, high blood pressure, or arthritis pain (including Advil, Motrin, and Aleve).

Other medications may interact with plazomicin, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor the medicines you are currently taking as well as any medicines you are about to start or stop taking.