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Generical name: salsalate [SAL-sa-late”
Names of brands: Disalcid, Salflex, Argesic-SA, Amigesic, Salsitab,… List the 8 names.
Dosage format: oral tablet (500 mg; 800 mg)
Class of drugs: salicylates

What is Salsalate?

It is a non-steroidal anti-inflammatory medication (NSAID) in a class of medications known as salicylates (sa-LIS-il-ates).

Salsalate can be used to ease swelling, pain, and stiffness in joints caused by rheumatoid arthritis, osteoarthritis, or rheumatic disease.It is also employed for reasons not mentioned in this medication guide.

Side effects of Salsalate

Contact emergency medical assistance when you are experiencing symptoms or warning signs of an allergic response (hives, breathing difficulties, or swelling of your throat or face) or an extreme skin reaction (fever or burning eyes, sore throat, or skin irritation; the skin is red or purple and blisters and peels).

The use of salsalate could cause serious adverse side effects. Stop using salsalate and consult your physician immediately. If you suffer from:

  • Swelling in your hands and feet; weight gain rapid;
  • A severe headache severe headache, blurred vision, and the pounding of your neck or ear;
  • Dull skin, unusual fatigue, and cold hands and feet;
  • Liver issues: nausea, stomach discomfort (upper right side) fatigue, itching, and jaundice (yellowing of the eyes or skin);
  • Symptoms of stomach bleeding: bloody or tarry stool and vomiting blood or spit that resembles coffee grounds
  • Heart attack symptoms: chest pressure or pain that is spreading to your shoulder or jaw; vomiting; sweating;
  • Symptoms of a stroke—sudden weakening or numbness (especially for one leg) or severe headaches, impaired speech, balance issues.

Adults who are older may be more likely to suffer adverse effects from salsalate.

Common negative effects of salsalate include:

  • Nausea;
  • Hearing issues;
  • An experience of spinning;
  • The rash
  • Abnormal tests of liver function.

This isn't a complete list of possible side effects, and other effects may also be present. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


The use of salsalate is not recommended when you suffer from severe kidney disease or you've had an extreme allergic reaction using aspirin, also known as an NSAID (nonsteroidal anti-inflammatory medication), or other salicylates.

Salsalate could increase the risk of a fatal stroke or heart attack. Don't take this medication prior to or following the heart bypass surgery (coronary bypass graft for the artery, also known as CABG). It can also trigger intestinal or stomach bleeding that can be fatal.

Prior to use this drug

Salsalate may increase the chances of having a fatal heart attack or stroke, even if you possess any risks. Avoid taking this medication prior to or following coronary bypass surgeries (coronary bypass graft for an artery, CABG) or CABG.

The use of salsalate can also trigger stomach or intestinal bleeding, which could be fatal. These problems can develop in a matter of minutes when you are making use of salsalate and are more common among older adults.

It is not recommended to make use of salsalate if you're sensitive to it or if you suffer from

  • Severe kidney disease
  • An allergy history that has been severe. Reaction to aspirin after taking an NSAID or any other salicylates.

Don't take this medicine when you're suffering from high fever or influenza symptoms, as well as chickenpox. Salicylates can trigger Reye's syndrome, which is a serious and often fatal disease, when you have one of these symptoms.

Speak to your doctor if you were ever diagnosed with:

  • Heart diseases, high blood pressure, heart failure, and congestive cardiac failure;
  • A heart attack or stroke
  • The swelling of or fluid retention or swelling;
  • A stomach ulcer;
  • The stomach or intestines may be bleeding.
  • Kidney or liver disease;
  • Asthma
  • A bleeding or blood clotting disorder.

If you are expecting, then you shouldn't take salsalate unless your doctor advises you not to. Taking an NSAID in the final 20 weeks before birth could result in serious kidney or heart problems for the unborn baby and possibly complications in the pregnancy.

It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.Senior adults could be more susceptible to the effects of this medication.

How to take salsalate?

Follow the directions on the prescription label and study all the medication guidelines. Choose the dosage that will be effective in treating your illness.It can take as long as 4 days to receive the full benefits of using salsalate. Your physician will decide the time frame for treating you by taking salsalate.

This medication may affect the outcomes of certain medical tests. Inform any physician who treats you about your use of salsalate.If you are in need of surgical intervention, dental work or medical treatment consult your physician you're currently using this medicine. You might have to stop the treatment for a short period of time.

If you are taking this medication for a long period of time, you could require regular medical examinations.Keep the bottle at room temperature, away from heat and moisture. Close the bottle when not being used.

Details on dosage

Usual Adult Dose for Osteoarthritis:

3000 mg per day orally in 3 or 2 divided doses
Lower doses are sometimes necessary for achieving therapeutic blood levels and to minimize more common adverse negative effects (e.g., auditory effects, etc.).
The reduction of symptoms occurs gradually, and the full benefit is not likely to be realized for 3–4 days.
Uses: For the treatment of symptoms and signs of osteoarthritis and rheumatoid arthritis and its rheumatic disorders

Usual Adult Dose for Rheumatoid Arthritis:

3000 mg per day orally in 3 or 2 equal doses
A lower dose may be required in order to attain a therapeutic blood level and to prevent more frequent adverse negative effects (e.g., auditory or visual effects).
The reduction of symptoms occurs gradually, and the full benefit is not likely to be realized for 3–4 days.
Uses: For the treatment of symptoms and signs of osteoarthritis, rheumatoid arthritis, and related rheumatic diseases

What happens if I miss the dose?

Because salsalate is only used in the event of need, you might not be following a dose schedule. Don't miss any doses when it's time to get the next dose. Don't take two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

Some of the symptoms of an overdose include the ringing of your ears, anxiety, headaches, dizziness, tiredness, sweating, rapid breathing, intense diarrhea, and vomiting.

What should be avoided?

Avoid alcohol. Drinking heavily can increase the chance of having stomach bleeding.Talk to your doctor or pharmacist prior to taking any other medications that could contain a salicylate (such as aspirin, magnesium salicylate, diflunisal, choline salicylate, Ecotrin, Tricosal, Trilisate, and more).

Talk to your doctor or pharmacist prior to using any other medicines to treat swelling, fever, pain, or symptoms of the cold or flu. They could contain ingredients like salsalate (such as aspirin, choline salicylate, and magnesium salicylate).Avoid driving and other hazardous activities until you understand how much salsalate can affect you. The way you react could be impaired.

If you're taking aspirin in low doses to prevent stroke or heart attack, don't discontinue taking it or alter your dosage without your doctor's recommendation. Aspirin should only be used to treat heart conditions in conjunction with a physician.Do not smoke, as it may also increase the chance of bleeding from your stomach.

Interaction with other drugs

Inform your doctor about your current medications. There are many drugs that may affect salsalate, but they are particularly:

  • Lithium;
  • Methotrexate;
  • Naproxen;
  • Phenytoin;
  • Penicillin;
  • A diuretic, or "water pill";
  • Oral diabetes medicine;
  • Heart or blood pressure medication—benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril;
  • A blood thinner: warfarin, Coumadin, Jantoven,
  • Steroid medicine—prednisone, dexamethasone, methylprednisolone, and others.

This isn't a complete list, and a variety of other medications could impact salsalate. This includes over-the-counter and prescription medications, vitamins, and herbs. The interactions of all drugs are listed here.



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