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Sacubitril and valsartan

Generic name: Sacubitril and valsartan [sak-UE-bi-tril-and-val-SAR-tan]

Brand name: Entresto
Dosage format: Oral tablet (24 mg–26 mg; 49 mg–51 mg; 95 mg–103 mg)
Class of drugs: Angiotensin receptor blockers and neprilysin inhibitors

What are Sacubitril and valsartan?

Sacubitril and valsartan are combination medications for adults suffering from persistent cardiovascular failure. Sacubitril and valsartan can reduce the likelihood of having to be admitted to the hospital when symptoms become worse. It also reduces the risk of dying from heart failure.

Sacubitril and valsartan are employed to address heart failure in children who have reached the age of 1.Sacubitril and valsartan are usually used in conjunction with other heart medications.Sacubitril and valsartan can also be used for other purposes that are not covered in this guide.

Side effects of valsartan and sacubitril

See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, such as symptoms of hives, breathing difficulties, and swelling of your lips, face, and tongue, You are more likely to suffer from a reaction to an allergen if you are African-American.

Make sure to contact your doctor at any time if you suffer from:

  • A lightheaded sensation, similar to what you've passed out;
  • Extreme tiredness;
  • High potassium -- low heart rate and weak pulse muscles becoming weak, tingly sensation high potassium;
  • Kidney issues: no or little urine or weight gain; rapid pain or difficulty in urine; swelling in your feet, hands, or ankles.

Common adverse effects of sacubitril and the drug valsartan can include:

  • Kidney problems;
  • High potassium
  • Dizziness, feeling light-headed,
  • Cough.

This isn't a complete list of possible side effects, and other side effects could be present. Consult your physician for medical advice regarding the effect. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Don't use this if you're pregnant. Contact your physician immediately you find out that you're expecting.

If you suffer from diabetes, take care not to combine sacubitril and valsartan with any other medication that contains the ingredient aliskiren (a blood pressure medication).

Before you take this drug

You should not take sacubitril or valsartan if you suffer from an allergic reaction to sacubitril or valsartan (Diovan) or have ever experienced an extreme reaction to an allergic reaction to a blood pressure medication like:

  • An ACE inhibitor—benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril (Lotensin, Vasotec, Prinivil, Accupril, Mavik, and others);
  • An ARB--azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, and valsartan (Atacand, Avapro, Benicar, Diovan, Edarbi, Micardis, Teveten, and others).

It is recommended not to take sacubitril or valsartan for more than 36 hours after the last dose of any ACE inhibitor medication.

If you suffer from diabetes, take care not to take sacubitril or valsartan with any other medicine that contains the ingredient aliskiren (a blood pressure medication).

There is a possibility that you should stay clear of sacubitril and the valsartan medication in combination with aliskiren in the event that you suffer from renal disease.

Inform your doctor if you were ever diagnosed with:

  • Liver disease;
  • The hereditary angioedema
  • If you are on diets that are low in salt,

Do not take it in the case of pregnancy, and inform your physician immediately if you are pregnant. Sacubitril and valsartan could cause harm or even death to the baby's unborn when you use the medication during the third or second trimester.It is not advised to give birth while taking the medicine.

How to take sacubitril and valsartan?

Follow all the instructions on the prescription label and go through all medication guides or instructions sheets. Your doctor may alter your dosage.Be sure to take your dosage exactly as directed.It is possible to take this medication without or with food.The doses of sacubitril and valsartan are based on weight gain in children. The dose requirements of your child could alter if your child gains or sheds pounds.

If you are unable to swallow the tablet completely, it is possible to create an oral suspension (liquid). Consult your physician if the person taking the medication is having trouble swallowing tablets.

Make sure to shake off the oral suspension (liquid) prior to determining a dose. Make use of the dosing syringe supplied or a dosage-recording device (not an ordinary spoon).Your blood pressure needs to be monitored regularly. The kidneys may be a factor to be monitored.

Storage at room temperature, free of heat and moisture. Get rid of the oral suspension that is not used within 15 days of the date of mixing. Do not store the suspension in an airtight container in a refrigerator.

Do I be concerned if I miss a dose?

Do not take the medicine for as long as you are able, but do not take any missed doses if you are nearing the time to take the next dose. Don't take two doses at a time.

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Don't take sodium supplements or substitutes for salt unless your physician has instructed you to.

Do not get up too quickly from a lying or sitting position, as you could be dizzy.

Interaction with other drugs

Discuss with your physician any other medication you use in particular:

  • Aliskiren;
  • Lithium;
  • Other heart or blood pressure medication;
  • Diuretic or "water pill";
  • Mineral supplements or medicines that contain potassium
  • The nsaids (nonsteroidal anti-inflammatory drugs) are aspirin, Ibuprofen (Advil, Motrin), naproxen (Aleve), Celecoxib, diclofenac (also known as indomethacin), diclofe, and many others.


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