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Generic Name: Quinapril [KWIN-april]
The Brand Name is Accupril.
Dosage Format: Oral tablet (10 mg; 20 mg; 40 mg; 5 mg)
Drug Class: Angiotensin-converting enzyme inhibitors

What is Quinapril?

Quinapril is a medication used by adults either on its own or with other medicines in order to manage hypertension of the blood (hypertension). Lowering your blood pressure can reduce your chance of having a stroke or heart attack.

Quinapril may also be prescribed to adults along with other drugs to treat heart failure.Quinapril can also be used for reasons not mentioned in this medication guide.

Side effects of Quinapril

Contact a medical professional immediately. Get medical attention immediately if you show symptoms that indicate an allergy, including hives, trouble breathing, and swelling of your lips, face, or tongue.

Quinapril may cause serious side effects. Contact your doctor immediately if you experience:

  • Chest pain; quick or slow heart rate;
  • A euphoric feeling, similar to when you're about to pass out.
  • Heart issues: swelling; rapidly gaining weight; sensation of being short of breath;
  • Kidney issues: swelling, less urination, and feeling tired;
  • Liver problems: loss of appetite, stomach discomfort (upper right), fatigue, itching, dark urine, stools that are clay-colored, jaundice (yellowing of the eyes or skin), or abnormal tests for liver function;
  • Symptoms of signs of infection symptoms of infection include fever, chills, a sore throat or body aches, unusual fatigue, loss of appetite, bleeding or bruising,
  • High blood potassium, nausea and weakness sensations, chest discomfort, irregular heartbeats, and decreased movement.

Common adverse effects of quinapril could include:

  • Headache;
  • Nausea, vomiting, and stomach pain;
  • Cough
  • Dizziness, tiredness.

There isn't an exhaustive description of the various adverse consequences. There are other possibilities for what could happen. Consult your doctor for medical advice about the effect. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Don't use it when you are expecting. Quinapril should be stopped, and you must inform your doctor as soon as possible if you are pregnant.

It is not recommended to use quinapril when you've had angioedema. Quinapril should not be taken within 36 hours prior to or after taking medication that includes sacubitril (such as Entresto).If you suffer from diabetes, you should not take quinapril with any medicine that includes the ingredient aliskiren (a blood pressure medication).

Before you Take this Drug

Quinapril should not be used.If you're sensitive to it, or

  • Have a history of angioedema
  • You are allergic to other ACE inhibitors, including benazepril and captopril. Also, you are allergic to fosinopril, lisinopril, moexipril, perindopril, or trandolapril.

Quinapril should not be taken within 36 hours of taking a medicine containing sacubitril (such as Entresto).

If you suffer from diabetes, don't take quinapril with any other medication that has an ingredient called aliskiren (a blood pressure medication).You might also have to avoid quinapril and aliskiren when you suffer from kidney problems.

Inform your doctor if you have ever suffered from:

  • A connective tissue disorder like Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
  • Heart issues;
  • Low blood pressure;
  • The potassium levels in the blood are high (hyperkalemia);
  • If you're on a diet that has low salt levels,
  • Low white blood cell count;
  • Diabetes;
  • Kidney problems (or if you're taking dialysis)
  • The liver condition.

Avoid using it when you are pregnant. Stop taking the medication and inform your doctor immediately if you find yourself pregnant. Quinapril can cause injury or even death to an unborn child if you take the medication during your third or second trimester.

Consult your doctor to determine whether it is safe to breastfeed while taking this medicine.

How to Take Quinapril?

Follow the instructions on the prescription label and study all medication guides or instruction sheets. The doctor might change the dosage. Follow the medication exactly as prescribed.The blood pressure of your patients will need to be regularly checked. Your liver or kidney function might also need to be checked.

Consult your doctor if you have persistent nausea or diarrhea or notice that you are sweating more than normal. It is possible to become dehydrated when taking quinapril. This could lead to poor blood pressure levels, electrolyte problems, or kidney failure.Speak to your doctor if you are planning a procedure.

If you suffer from elevated blood pressure, continue taking quinapril, even if you feel good. High blood pressure can have no signs.Keep tightly sealed in a cool, dry place far from heat and moisture.

Details on Dosage

Usual Adult Dose for Hypertension:

Initial dose: 10 to 20 mg orally, once a day, for patients who aren't on diuretics.
Maintenance dosage: 20 to 80 mg per day orally taken as one dosing or two doses equally divided.
Treatment of hypertension

Usual Adult Dose for Congestive Heart Failure:

Initial dosage: 5 mg every day, taken orally.
Dosage for maintenance 20–40 mg daily, orally administered in two doses equally divided
This dose can help alleviate signs of heart problems; however, increased exercise duration is generally associated with greater doses.
If the initial dose is well tolerated, the patient should then be adjusted at weekly intervals until they have reached an effective dose.
Management of heart failure as an adjunct to standard treatment, such as diuretics or digitalis

Usual Geriatric Dose for Congestive Heart Failure:

10 mg taken orally, once a day
Comment: The dose should be titrated exactly the same way as for adults with other conditions.
Treatment of hypertension
Management of heart failure is an adjunctive therapy when it is combined with traditional therapy, such as diuretics or digitalis.

Usual Geriatric Dose for Hypertension:

10 mg taken orally, once a day
Comment: Dose should be titrated in the same manner as for other adult patients.
Treatment of hypertension
Management of heart failure as an adjunct to traditional therapy, such as diuretics or digitalis

What Happens If I Miss a Dose?

Do not take the medicine for as long as you can. However, do not take any missed doses if it's nearing the time to take the next dose. Don't take two doses at once.

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What Should be Avoided?

Don't supplement your potassium intake with potassium or salt substitutes unless your doctor has advised you to.Do not get up too quickly from a lying or seated position, as you could get dizzy.

Beware of becoming dehydrated or overheated during workouts, in hot weather, or if you don't drink enough fluids. Follow your doctor's advice on the kind and quantity of fluids you need to consume. In certain instances, drinking too much liquid can be just as harmful as not drinking enough.Do not exercise vigorously if you suffer from heart problems. Consult your physician about the risks.

Interaction with Other Drugs

Discuss with your doctor any other medications you take, particularly:

  • Lithium;
  • Diuretic or "water pill";
  • Gold injections for the treatment of joint pain;
  • Temsirolimus, sirolimus, or everolimus;
  • These are NSAIDs (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen, aspirin (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac (also known as indomethacin), diclofe, and many more.

This list is not comprehensive. Other medications can affect quinapril. These include prescription and over-the-counter medicines, vitamins, and herbal products. Some interactions with drugs are not listed here. are listed here.