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The Generic Name is Progesterone (proe-JESS-tee-rone). Progesterone [proe-JESS-tee-rone]
Names of Brands: First Progesterone MC10, Menopause Formula Progesterone, Prometrium
Drug Class: Progestins

What is Progesterone?

Progesterone is a natural hormone that is essential for the control of the menstrual cycle and ovulation. Progesterone occurs in large quantities in females through the ovaries. It is also made in lesser quantities from the adrenal glands of both males and females.

Progesterone can trigger menstrual periods for women who haven't yet gone through the menopausal stage but do not have periods because of a deficiency of progesterone within the body. Progesterone can also be used to stop the growth of the uterus' lining in postmenopausal women who are taking estrogen replacement therapy.

Progesterone shouldn't be used to treat dementia or heart disease since it could increase the chances of developing these diseases.


Avoid using progesterone unless you have informed your doctor that you are expecting. It may cause harm to your unborn baby. Choose a reliable method of birth control. Also, consult your physician if you are pregnant while receiving treatment.

You shouldn't use progesterone when you experience abnormal vaginal bleeding, have a history of breast cancer or the disease of the liver, or have recently suffered an attack on your heart, a stroke, or a blood clot.

Progesterone shouldn't be used to prevent dementia or heart disease since this medication could increase the likelihood of developing these diseases.Progesterone use can increase the risk of stroke, blood clots, and breast cancer.Certain forms of this medication might have peanut oil. Avoid using this medicine without consulting your physician if you suffer from an allergy to peanuts.

Before you Take this Drug

Progesterone should not be used if you have an allergy to it or suffer from

  • Abnormal vaginal bleeding that doctors have not inspected;

  • An antecedent history of breast cancer

  • Liver disease;

  • An allergy to peanuts;

  • If you are pregnant;

  • If you've had an attack, stroke, or blood clot during the last 12 months,

  • If you've had an incomplete miscarriage or "missed" abortion.

Progesterone use can increase the risk of stroke, blood clots, and breast cancer.

To ensure that this medication is appropriate for you, consult your doctor if:

  • Circulatory problems, heart disease;

  • Migraines;

  • Asthma;

  • Kidney disease;

  • Seizures or epilepsy;

  • An underlying depression history;

  • Risk factors that could lead to coronary artery diseases (such as high blood pressure or diabetes, lupus, high cholesterol, a family history of coronary disease, smoking, or being overweight).

Do not take progesterone if you are expecting. It could harm the unborn baby. Inform your doctor if you are expecting or planning to be pregnant.

Progesterone is a hormone that can be found in the milk of a nursing baby and cause harm to the infant. Consult your physician if you are breastfeeding the baby.

How to take Progesterone?

Make sure you use progesterone according to the prescription given to you. Follow the directions on the prescription label. Do not take this medication in smaller or larger quantities or for longer periods than the recommended time.

Take note of all patient information, including medication guides and instructions provided to you. Talk to your pharmacist or doctor for assistance if you have concerns.Consume this capsule by drinking a glass of fluid. It is advised to take it in the evening since this medication could make you feel dizzy or sleepy.Apply the cream of progesterone to your skin as directed by your physician.

Progesterone may be employed for a limited period of time, like between 10 and 12 days during the menstrual cycle. Follow your doctor's instructions for dosage with care.Regularly conduct physical examinations and examine the breasts to find lumps every month when you are taking progesterone.

If you are in need of medical or surgical tests or are bedridden, it is possible to stop taking this medication for a brief period of time. Any surgeon or doctor who treats you must be aware that you're using this medication.

Maintain room temperature and without moisture, heat and light.

What Happens If I Miss a Dose?

Utilize the dose you missed when you remember.

Be sure to avoid missed doses when it's getting close to the time of your next dosage. Avoid taking any extra medicine in order to replace the dose you missed.

Consult your doctor if you do not take a dose of this medicine.

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What Should be Avoided?

Progesterone could affect your reaction or thinking.

Take note of when you drive or engage in activities that require you to stay alert.

Side effects of Progesterone

Get immediate medical attention. If you are experiencing symptoms that indicate you are experiencing an allergic reaction due to progesterone, asthma; hives or swelling of your lips, face, and tongue

Contact your doctor immediately. If you suffer from:

  • Abnormal vaginal bleeding;

  • Discomfort or burning sensation after you urinate;

  • A breast lump

  • Suddenly experiencing vision problems, extreme headaches, or eye pain;

  • Signs of depression (sleep issues, fatigue, and mood swings);

  • Extreme dizziness or drowsiness, a spinning sensation, dizziness, confusion, or a shortness of breath.

  • Heart attack symptoms include chest pressure or pain radiating into your shoulder or jaw, nausea, sweating, and vomiting.

  • Liver issues: nausea, upper stomach discomfort, itching, fatigue, and loss of appetite. dark urine, stools that are clay-coloured, and jaundice (yellowing of the eyes or skin);

  • Symptoms of a stroke: the sudden feeling of weakness or numbness (especially for one leg), an abrupt extreme headache, blurred speech, or issues with balance or speech;

  • Symptoms that a blood clot has formed within the lung, such as chest pain, a sudden cough and wheezing or rapid breathing, coughing up blood,

  • Symptoms that a blood clot has formed within your leg, such as inflammation, pain, warmth, or redness in either or both of your legs.

Common side effects of progesterone include:

  • Drowsiness, dizziness;

  • Breast pain;

  • Mood shifts;

  • Headache;

  • Constipation, diarrhea, and  heartburn;

  • Bloating or swelling on your feet or hands;

  • Joint pain;

  • Hot flashes, hot flashes,

  • Vaginal discharge.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

There could be other drugs that affect progesterone. Inform your doctor about the medications you are taking. This includes prescriptions, over-the-counter vitamins, herbal products, and vitamin products. Don't start an entirely new drug without consulting your doctor.



Prescription only

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