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Generic name: hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate [HYE-oh-SYE-a-meen, meth-EN-a-meen, METH-il-een-BLUE, FEEN-il-sa-LIS-il-ate, SOE-dee-um-bye-FOS-fate]
Names of brands: Phosphasal, Urelle, Uribel, and Urimar-T. Urin D/S… Show the 15 brands.
Classification of drugs: Urinary antispasmodics

What is Phosphasal?

Hyoscyamine is a chemical that produces a range of effects on the body, such as the relief of muscle spasms. Methenamine and Methylene Blue are mild antiseptics to fight the growth of bacteria that cause urinary tract infections and bladder infections.

Phenyl salicylate acts as a mild painkiller. Sodium biphosphate is a type of phosphorus. It is an element that naturally occurs and is essential in every cell of the body. Phosphasal is a mixture of medications used to treat bladder irritation (pain spasms, inflammation, and pain) due to urinary tract infections. Phosphasal also helps to alleviate discomfort in the bladder during medical procedures. Phosphasal can also be employed for other purposes that are not covered in this guideline.

Side Effects

See a doctor immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, like hives, trouble breathing, or swelling of your lips, face, or tongue.

This medication could cause severe adverse consequences. Take this medicine off and contact your doctor immediately if you suffer from:

  • Severe dizziness, blurred vision, and a fast heart rate;
  • Difficulty or painful urination and
  • Breath shortness.

Adults who are older may be more likely to experience adverse reactions from this medication.

Methylene blue is likely to cause your stools or urine to appear green or blue in hue. This is a common consequence of the drug and won't cause harm.

Common adverse effects of phosphasal could include:

  • Dizziness, drowsiness;
  • Dry mouth or
  • Nausea, vomiting.

This isn't a complete list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


A variety of drugs may be incompatible with methylene blue. While you're taking this medication, you should not discontinue or start using any other medication without your doctor's approval.

If you are taking an antidepressant or other psychiatric medication, contact your doctor immediately if you notice indications of a dangerous drug interaction. This could include confusion, memory issues, and feeling overly active (mentally and physically), loss of motor coordination, sweating, shivering, diarrhea, and/or fever.

Prior to use this drug

It is not recommended to use this medicine if you're allergic to methenamine, hyoscyamine, methylene blue, phenyl salicylate, or sodium biphosphate. While you are receiving treatment using this medicine, don't take or stop taking other medicines unless your physician tells you to. To ensure that this medication is suitable for you, inform your doctor if:

  • Heart disease;
  • A heart rhythm disorder
  • Congestive heart failure;
  • Coronary heart diseases;
  • A heart valve disorder;
  • Glaucoma;
  • An enlarged prostate or bladder obstruction
  • Myasthenia gravis;
  • An obstruction or ulcer in your stomach.
  • An allergy, an allergy belladonna (Donnatal and other); or
  • Allergies to salicylates (such as aspirin, choline, magnesium trisalicylate, and magnesium salicylate).

It is unclear if this medication can cause harm to a baby who is not yet born. Inform your physician if you are expecting or planning to become pregnant while taking this medication. This medication can be absorbed into the breast milk and could cause harm to a nursing infant. Inform your doctor if you are breastfeeding a child. Don't give the medication to children without obtaining medical guidance.

How to take Phosphasal?

Follow the directions on the prescription label. Don't take this medication in greater or lesser quantities or for longer than the recommended time.Drink plenty of fluids while you take this medicine. Hyoscyamine can cause a slowing of digestion and may take longer before your body is able to take in any medication you are taking by mouth. Keep the bottle at room temperature, far from heat, moisture, and light. Close the bottle when not being used.

What happens if I miss the dose?

You should take the missed dose as soon as you can remember. Avoid your missed dosage if you are nearing the time for the next dose. Do not take a second dose to make up for the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Do not take an antacid or anti-diarrhea medication within one hour prior to or following the time you have taken methenamine, hyoscyamine, methylene blue, phenyl salicylate, and sodium biphosphate. Antacids or anti-diarrhea medications can hinder your body's ability to absorb hyoscyamine. If you are also taking ketoconazole (Nizoral), make sure you take it at least two hours after taking hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium biphosphate.

Interaction with other drugs

A variety of drugs may interfere with methylene blue. Discuss with your doctor any other medications you take. It is possible that you will be required to stop taking certain medications (in some instances, for at least 5 weeks prior to when you begin the treatment process for phosphasal). But you should not stop taking any medication without consulting your doctor. This includes:

  • Any antidepressant of any kind;
  • Diuretics, stimulants, anti-cold or allergy medications, and adhd medication;
  • Narcotic pain medication
  • Medications used to manage the symptoms of parkinson's disease (also known as restless leg syndrome);
  • A "triptan" migraine headache

If you take any of the above medicines while taking a medicine that contains methylene blue, it could result in the body producing high levels of serotonin within the human body. Consult your doctor immediately if you are experiencing symptoms of this disorder, such as anxiety and hallucinations. also fever, rapid heart rate, excessive reflexes, nausea, vomiting, diarrhea, or loss of coordination, and feeling faint.

Numerous drugs may interact with this drug. There are many possible interactions that are not mentioned here. In addition, hyoscyamine could cause problems for the body to absorb any other medication you consume by mouth. Discuss with your physician the medications you take and those you stop or begin using, including:

  • Diuretic, also known as a "water pill";
  • Drugs that change the ph of your urine: sodium bicarbonate, potassium citrate, citric acid, or potassium
  • Bladder or urinary medicines—darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin; or
  • A sulfa drug.

The list below is not exhaustive, and a variety of other medications can be incompatible with phosphasal. This includes over-the-counter and prescription medications, vitamins, and herbal remedies. Provide an inventory of all your prescriptions to any health professional who cares for you.