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What is Pexidartinib?
Pexidartinib is used by adults to treat a tumor of giant cells within the sheath of the tendons (also known as tenosynovial giant cell tumor, also known as pigmented villonodular synovitis), which is not likely to be improved by surgical intervention. Pexidartinib is available only through an accredited pharmacy that is part of an exclusive program. You must be enrolled in the program and know the potential risks and advantages of pexidartinib. Pexidartinib can also be employed for other purposes that are not covered in this guideline.
Side effects of Pexidartinib
See a doctor immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as hives, difficulty breathing, or swelling of your lips, face, and tongue.
Stop taking pexidartinib, and contact your doctor immediately in case you experience an unusually dark or jaundice (yellowing of the eyes or skin).
Inform your physician if you have any other signs of liver issues, for example:
- Upper stomach pain on the right side;
- Loss of appetite vomiting, nausea, nausea;
- Rash;
- Fever, tiredness, or
- Itching.
The doses of pexidartinib may be delayed or discontinued permanently in the event of specific side effects.
Common side effects of pexidartinib include:
- Abnormal lab results;
- Tiredness;
- Puffy eyes;
- Hue of your hair
- Hives, hives, itching or acne, redness of the skin,
- Diminished or changed sense of taste.
This isn't a complete list of possible side effects, and others could happen. Contact your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.
Warnings
Pexidartinib may cause liver damage. You'll need regular tests to determine the liver's function prior to and during treatment with pexidartinib.
Stop using pexidartinib immediately and consult your doctor immediately. If you notice the dark color of your urine, jaundice (yellowing of the eyes or skin).
Inform your doctor whether you are experiencing other signs of liver disease, like nausea or stomach discomfort (upper right side), fatigue, nausea, vomiting, and itching. You may also experience a fever.
Before you take this drug
Speak to your doctor if you have ever experienced:
- Kidney or liver disease
Pexidartinib could harm an unborn baby when the father or mother uses this medication.
- If you're female, you may need an examination for pregnancy to make sure that you're not expecting. Take contraceptives when you take this medication and for a minimum of one month after the last dose.
- If you're male, use birth control in the event that your partner is likely to get pregnant. Use birth control for a minimum of one week following the last dose.
- Contact your doctor immediately in the event of a pregnancy.
The likelihood of pregnancy is higher when the father or mother is taking this medication. Both women and men are advised to use birth control to stop pregnancies because this medication could affect a newborn baby. Don't breastfeed while taking this medication, and at least a week following the last dose.
How to take Pexidartinib?
Follow the directions on the prescription label and review all medication guides and instructions sheets. Make sure you use the medicine exactly as prescribed. Pexidartinib capsules containing 125 mg are typically taken two times a day along with a meal that is low in fat (about 11–14 grams of fat). Pexidartinib capsules (200 mg) are generally taken twice each day on an empty stomach. They should be taken at least one hour prior to or two hours following an eating or snack.
Suck the capsule whole, and don't crush, chew, break, or break it open. If you vomit immediately after taking pexidartinib, do not take a dose again. Your next dose must be taken in the same way as per the schedule.
It is necessary to conduct tests on your blood to determine the function of your liver prior to and during treatment with pexidartinib. Your next dose could be delayed depending on the results of the tests for your liver function.Keep the tablets at room temperature, free of heat and moisture. Place tablets in the original container together with the package or canister of preservative that absorbs moisture.
Details on dosage
Usual Adult Dose for Giant Cell Tumor of Bone:
400 mg orally, 2 times every day
Use: To treat symptoms (TGCT) that are associated with serious functional limitations or morbidity and are not able to improve through surgery.
Do I be concerned if I miss a dose?
Don't miss the dose you missed, and take the next dosage at your regular time. Don't take two doses at the same time.
What will happen if I take excessively?
Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.
What should be avoided?
Grapefruit can be in contact with pexidartinib. This can have negative side effects. Avoid consuming grapefruit products.
Interaction with other drugs
It is sometimes not safe to take certain medications in conjunction with other medications. Certain medications can alter your blood levels and the other drugs that you are taking, which can cause more side effects or make the medications less effective.
Pexidartinib may affect your liver, specifically when you are also taking certain medications to treat depression, tuberculosis and infections, hormone replacement, birth control and heart problems, high cholesterol and high blood pressure, seizures, and pain (including Tylenol Advil, Motrin, or Aleve).
Certain medicines are best taken in isolation from the dose of pexidartinib.
- If you are taking an antidepressant and you take a dose of pexidartinib, do so 2 hours prior to or 2 hours after the time you consume the antacid.
- If you're taking medication for stomach acid or heartburn (such as cimetidine, ranitidine, or famotidine, Pepcid, Tagamet, or Zantac), be sure to take your dose of pexidartinib 2 minutes prior to or 10 hours following the time you took the anti-acid.
You might not be able to use an inhibitor of the proton pump stomach acid reducer, such as dexlansoprazole, esomeprazole, lan, and omeprazole. Pantoprazole is a substitute for rabeprazole, Nexium, Prevacid, Prilosec, Protonix, and many more.