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What is Pasireotide?
Pasireotide is a protein made by humans that resembles an organ-specific hormone known as somatostatin.
Pasireotide can be used to treat Cushing's disease as well as acromegaly (endocrine diseases). The treatment is typically given following surgical procedures or any other treatment that didn't work, failed, or was discontinued.
Pasireotide can also be employed for other purposes that are not covered in this guideline for medication.
Side effects is Pasireotide
See a doctor immediately. If you are experiencing warning signs of allergic reactions such as hives, difficulty breathing, and swelling of your lips, face, or tongue,
Pasireotide can cause serious adverse reactions. Consult your physician immediately. If you suffer from:
- Heartbeats that are slow or fast;
- Suddenly dizzy (like it could be a sign that you're passing out);
- Higher blood sugar—increased thirst, more frequent urine output, a fruity breath smell, fatigue, loss of weight, even if you're more hungry than normal;
- Ketoacidosis (too much acid in the blood) ketoacidosis (too much acid in the blood) vomiting, stomach discomfort, confusion, tiredness, or difficulty breathing;
- Low levels of cortisol—nausea or vomiting, changes in appetite, headache, disorientation, and confusion. It can also cause slurred speech, slurred thoughts, or feeling tired, weak, and anxious. shaking or lightheaded as well as
- Gallbladder problems—chalky-colored stools, stomach pain just after eating a meal, heartburn, bloating, and upper stomach pain that may spread to your back.
Common side effects of pasireotide include:
- High blood pressure;
- Abnormal results from blood tests;
- Being tired or weak;
- Loss of appetite; nausea, stomach gastric pain, or bloating; vomiting;
- Headache;
- Swelling and rapid weight gain
- Back pain;
- Cold symptoms like congestion of the nose and sneezing;
- Hair loss,
- Discomfort, redness, itching, bleeding, or bruises in the area where the medicine was injected.
This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your doctor for guidance about medical-related adverse reactions. It is possible to report any symptoms to the FDA by calling 1-800-FDA-1088.
Similar/related drugs
dexamethasone, Decadron, Cyproheptadine, Octreotide, Mifepristone, Bromocriptine, and Sandostatin
Warnings
Pasireotide could reduce your cortisol levels. Tell your doctor when you experience symptoms like nausea or vomiting, changes in appetite, headaches, irritability, blurred speech, or feeling tired, weak, or anxious. You may also feel unsteady, agitated, unstable, or lightheaded.
Pasireotide may increase your blood sugar levels and result in diabetes. Your blood sugar could require testing prior to and during treatment with pasireotide. Consult your physician if you notice a rise in thirst, fatigue, urination, or weight loss even though you're more hungry than normal.
Before you take this drug
It is not recommended to use pasireotide if your body is allergic to it.
Inform your doctor if you have ever suffered from:
- Diabetes, also known as high blood sugar,
- The liver condition;
- Heart-related problems;
- Gallstones
- The imbalance of electrolytes (such as low concentrations of magnesium, potassium, or magnesium in the blood).
It is unclear if pasireotide can harm the unborn child. Inform your doctor if you are expecting or planning to be pregnant.
Pasireotide could alter hormone levels in a woman who is premenopausal. This can increase the likelihood of having a pregnancy that is not planned. Consult your physician regarding your potential risk.
Breastfeeding is not a good idea while using pasireotide.
How to take Pasireotide?
The doctor will conduct tests on your blood to ensure that you don't have any issues that could hinder you from using pasireotide.
Follow the directions on the prescription label and review all medication guides and instruction sheets. Your doctor may alter your dosage. Be sure to take your dosage exactly as directed.Pasireotide can be injected under the skin or into muscles. A doctor can show you how to correctly use the drug on your own.
The LAR Signifor is injected into the muscle every four weeks. The healthcare professional will provide this kind of injection.Be sure to read and adhere to any instructions that are included with your medication. Consult your physician or pharmacist for clarification if you aren't sure about the instructions.
Your doctor will inform you of the best place on your body to administer pasireotide. Make sure to inject at a different location each time you administer an injection. Don't inject the same spot twice in the same row. Do not inject into skin that is irritated or red.
Pasireotide may increase your blood sugar levels, and you could be diagnosed with the condition of diabetes or pre-diabetes. The blood sugar level will need to be measured prior to and during medication with pasireotide. It is possible that you will need to begin taking diabetes medication or alter the dosage of the medication you are already taking. Follow the directions of your doctor meticulously.
The function of your heart may require a check with an electrocardiograph, or ECG (sometimes known as an EKG).Keep the signifier at room temperature, away from heat, moisture, and light. Discard an ampule after one use, even if there's some medicine remaining in it.
If you keep Signifor the LAR in your home environment, make sure to keep its original packaging and store it in the refrigerator. Don't freeze it. Remove the medicine from the refrigerator and allow it to be at room temperature for 30 minutes prior to injecting your dose. Do not keep the medicine in the refrigerator for more than 24 hours.Use a needle or the syringe once only and put them in the puncture proof "sharps" container. Be sure to follow the laws of your state or city on how to dispose of the container. Make sure it is out of reach of pets and children.
Details on dosage
Usual Adult Dose for Cushing's Syndrome:
Intramuscular formulation:
Initial dose: 10 mg intramuscularly every four months (28 days).
Maximum dosage: 40 mg intramuscularly each for 4 weeks (28 days) after four months of treatment using 10 mg for patients who do not have normalized 24-hour urinary cortisol (UFC) levels following 4 months of treatment and who have tolerated the dose of 10 mg.
Subcutaneous formulation:
Initial dosage: 0.6 mg or 0.9 mg subcutaneously, twice a day.
Dosage for maintenance: 0.3 to 0.9 mg subcutaneously, twice daily.
Maximum dosage: 0.9 mg subcutaneously twice each day.
The duration of treatment: Therapy is to be continued to the extent that benefits are realized.
Comments:
The titrate dose is based on response and tolerance.
Perform baseline assessments of plasma fasting glucose and hemoglobin A1c electrocardiograms, liver tests, and serum potassium and magnesium levels prior to starting therapy.
-Optimize the control of glucose in diabetics who are not well controlled prior to initiating treatment.
Treatment: The treatment for adult patients suffering from Cushing's disease who have had pituitary surgery that does not work or hasn't been curative
Usual Adult Dose for Acromegaly:
Intramuscular formulation:
Initial dose: 40 mg, IM, every 28 days
Maximum dose: 60 mg IM at least every 28 days for those without normal levels of growth hormone (GH) or age and sex-adjusted IGF-1 (IGF-1) concentrations after three months of treatment who were able to tolerate the dose of 40 mg.
Comments:
The titrate dose is based on response and tolerance.
Assess fasting plasma glucose levels, HbA1c levels, liver enzymes, electrocardiogram, and potassium and magnesium levels in the serum prior to treatment.
Optimize glucose control in people with poorly controlled diabetes prior to starting therapy.
Treatment for patients suffering from acromegaly who have an insufficient response to surgery or for whom surgery isn't an alternative
What happens If I miss a dose?
Utilize the medicine as soon as you are able, but take a break from any missed doses if it's close to the time for the next dose. Don't take two doses at once.
If you don't take your dosage of the drug Signifor L.A., you may be given a missed dose within 14 days prior to the next dose.
What happens if I overdose?
Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.
What should be avoided?
Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.
Interaction with other drugs
Pasireotide could cause serious heart conditions. The risk is higher if you take different medicines to treat asthma, infections, heart issues, high blood pressure, mental illness, depression, malaria, cancer, or HIV.
Inform your doctor about the medicines you are taking currently. A variety of drugs can interact with pasireotide, including:
- Bromocriptine;
- Cyclosporine;
- Heart or blood pressure medications and
- Medicines to lower the blood levels of magnesium and potassium.
This is not a complete list, and other drugs could influence pasireotide. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. The interactions of all drugs are included here.