What is Palonosetron?
Palonosetron is used by adults to reduce vomiting as well as vomiting that is caused by surgery or when receiving medication to treat cancer (chemotherapy).
Palonosetron is a medication used by infants as young as one month old to help prevent nausea and vomiting that can be caused by cancer drugs.Palonosetron could also be used to treat conditions not covered in this medication guide.
Side effects of Palonosetron
Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergy, such as chest pain, breathing difficulty, or swelling of your lips, face, or tongue,
Take immediate medical attention if you are experiencing signs that suggest serotonin syndrome, which include hallucinations, agitation, sweating, chills, shivering, rapid heart rate, muscle stiffness and twitching, loss of coordination, nausea, vomiting, or diarrhea.
Common adverse effects of palonosetron could include:
- Nausea, vomiting;
- Constipation;
- Slower heartbeats;
This isn't an exhaustive list of all the side effects. Others could happen. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.
Warnings
Before receiving palonosetron, inform your doctor of all medical conditions or allergies, as well as all the medications you're taking. Make sure your doctor is aware that you are breastfeeding or pregnant.
Interaction with other drugs
It is not recommended to treat with palonosetron if a person is allergic to it.Discuss with your physician if you have had any allergic reactions to the same medication to treat nausea or vomiting, like dolasetron (Anzemet) or ondansetron (Zofran).
Check with your physician whether you are also taking medication that is a stimulant, opioid, herbal product, or medicine to treat depression or mental illness. Parkinson's disease, migraine headaches, grave infections, and the prevention of vomiting and nausea These medicines can interfere with palonosetron and create a serious illness known as serotonin syndrome.
Consult your physician if you are breastfeeding or pregnant.
How to take Palonosetron?
Palonosetron is injected as an infusion into the vein. Your healthcare professional will offer the injection.
Palonosetron is typically administered 30 minutes prior to chemotherapy or just prior to being provided with anesthesia to undergo surgery.
Details on dosage
Usual Adult Dose for Nausea and Vomiting -- Chemotherapy Induced:
0.25 mg IV infusion over 30 seconds, a minimum of 30 minutes prior to the beginning of chemotherapy
Comments:
The infusion line must be flushed using normal saline prior to and following the administration of this medication.
It is not recommended to be used in conjunction with other drugs.
Uses:
Prevention of delayed and acute vomiting and nausea that is associated with the initial and subsequent chemotherapy for moderately emetogenic cancer chemotherapy
Prevention of the acute vomiting and nausea that are associated with repeat and initial chemotherapy for cancer that is highly emetogenic. chemotherapy
Usual Adult Dose for Nausea and Vomiting -- Postoperative:
0.075 mg IV injection for 10 seconds immediately prior to the induction of anesthesia
Comments:
The effect beyond 24 hours hasn't been established.
Routine prophylaxis is not advised for patients when there is no chance of nausea or vomiting postoperatively (PONV).
Use is advised in situations in which nausea or vomiting must be avoided after surgery, even if the risk of PONV is very low.
Use: Preventing PoNV in the first 24 hours after surgery
Usual Pediatric Dose for Nausea and Vomiting -- Chemotherapy Induced:
1 month to 17 years: 20 mg/kg by IV infusion of 15 seconds at a time of 30 minutes prior to the start of chemotherapy
Maximum dose: 1.5 mg
17 years old and over: 0.25 mg via IV infusion of 30 seconds or more ONCE 30 minutes prior to the start of chemotherapy
Comments:
The infusion line should be cleansed using normal saline prior to and following the administration of this medication.
It is not recommended to be used in conjunction with other drugs.
Uses:
Patients aged 1 month to less than 17 years old: Preventing acute nausea and vomiting that is associated with the initial and subsequent courses of chemotherapy for cancer that is emetogenic as well as chemotherapy for cancer that is highly emetogenic.
Patients 17 years old and older Preventing delayed and acute nausea and vomiting as a result of the repeated and initial treatments of moderately emetogenic chemotherapy
Patients aged 17 and over Preventing nausea and vomiting in acute form that can be associated with the initial and subsequent chemotherapy for cancer that is highly emetogenic
What happens If I miss a dose?
Since you'll be receiving palonosetron in a clinical setting, it is unlikely that you'll skip the dosage.
What happens if I overdose?
Because palonosetron is administered by a medical expert in a medical environment, it is highly unlikely for an overdose to occur.
What should be avoided?
Follow the instructions of your physician regarding any limitations on foods, drinks, or any activity.
Interaction with other drugs
Numerous drugs can affect palonosetron. This includes prescription and over-the-counter medications, vitamins, and herbal supplements. The interactions of all drugs aren't mentioned in this article. Inform your doctor of all the medications you are currently taking as well as any new medications you are about to start or stop taking.
