The Web Health



Generic Name: Pentamidine [pen-TAM-e-deen]
Brand Names: Nebupent, Pentam 300
Classes of Drugs: Inhaled anti-infectives, miscellaneous antibiotics

What is Nebupent?

Nebupent is an antifungal medicine that combats the effects of fungus.

Nebupent can be used to prevent and manage the symptoms of pneumonia due to Pneumocystis Jiroveci (Carinii).Nebupent can also be employed for other purposes that are not covered in this guideline.

Side effects of Nebupent

See a doctor immediately. If you experience any of the following symptoms as warning signs of reactions to an allergen: hives, trouble breathing, or swelling of your lips, face, and tongue,

Nebupent may cause serious side effects. Consult your doctor immediately in the event of:

  • Wheezing or choking or other breathing issues after taking this medication with the help of a nebulizer
  • A feeling of lightheadedness, as if you're about to pass out.
  • Heart rate that is irregular or fast;
  • Uncomfortable or difficult to urinate;
  • Confusion, hallucinations;
  • Discomfort, burning, or changes to the skin where the injection was administered;
  • Signs of the onset of new symptoms or signs of new symptoms (fever, cough, difficulty breathing, or night sweats);
  • A blood cell disorder that causes pale skin, feeling lightheaded or shaky, frequent bleeding, and easy bruising in red or purple spots on your skin
  • Pancreatitis—severe discomfort in your upper stomach, which spreads into the back of your body, nausea, and vomiting;
  • Low blood sugar: headache or hunger, sweating, confusion, and irritability or feeling jittery.
  • Extreme skin reaction, fever, sore throat, swelling on your tongue or face, burning in your eyes, skin irritation that is followed by an irritated or purple rash that spreads (especially on the face or the upper body) and leads to blistering and peeling.

Common negative side effects of Nebupent can include:

  • Loss of appetite;
  • A strange or unpleasant taste is present inside the mouth.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


Follow the directions on your prescription label and the package. Be sure to inform your healthcare professionals about your medical issues, allergies, and the medicines you are taking.

Before you take this drug

Nebupent is not a good choice if you have an allergy to it.

To be sure Nebupent is suitable for you, inform your doctor that you have:

  • Blood pressure (or lower blood pressure;
  • A heart rhythm disorder
  • Diabetes and the low level of blood sugar (hypoglycemia);
  • A pancreas disorder;
  • A severe skin rash called Stevens-Johnson syndrome;
  • Anemia (low red blood cells);
  • Low white blood cell count or the presence of low levels of platelets.
  • Low levels of calcium or the high level of potassium present in your blood.
  • Kidney disease or liver failure,
  • A past history that includes cigarettes as well as the presence of asthma.

FDA classification for pregnancy C It isn't known whether Nebupent could harm an unborn baby. Consult your physician if you are expecting or plan to become pregnant while taking the medication.

It is unclear if pentamidine gets into breast milk or if it can harm nursing babies. It is not recommended to breastfeed while taking Nebupent.Nebupent inhalation should not be administered to a child without consulting an experienced physician.

How to Take Nebupent?

Nebupent can be administered in the form of an injection or in the form of inhaled medication with the nebulizer. Follow the instructions on the prescription label. Do not take this medicine in smaller or larger quantities or for longer periods than the recommended time.

Nebupent is a medication in powder form that must be mixed with liquid (diluent) prior to injecting it with a needle. If you're using the medicine at home, ensure you know how to combine and preserve the drug. Only use the diluent supplied in your prescription.

To utilize Nebupent as an injector:

  • Nebupent is injected into the muscle or vein via an IV. It may be demonstrated to you how to inject an IV at home. Don't inject yourself with this medication when you don't know how to inject it, and dispose of the needles that are no longer needed, such as IV tubing, IV needles, and other equipment used to inject the drug.
  • Do not take Nebupent when it's changed color or contains particles. Contact your pharmacist to inquire about a new medicine.
  • Contact your physician. If you experience any pain, burning, or swelling in the area of your IV needle after Nebupent is administered,
  • Make use of a disposable needle once and then dispose of it in a container that is puncture-proof (ask your pharmacist where to get one and the best way to get rid of it). Keep the container out of the reach of pets and children.

To make use of Nebupent in conjunction with a nebulizer

  • After mixing the medicine with the diluent, you can pour the entire mixture into the nebulizer's chamber. Attach the mask or mouthpiece before attaching the chamber for the drug to the compressor.
  • Do not mix other medications within the nebulizer Nebupent.
  • Relax and sit upright in a comfortable posture. Put the mouthpiece in your mouth, or put on the mask to cover your mouth and nose. The compressor should be turned on.
  • Breathe slowly and evenly until more mist is created by the nebulizer. The drug chamber is empty.
  • Clean the nebulizer after every use. Follow the cleaning guidelines on the nebulizer's packaging.

If you suffer from diabetes, be sure to take note of your blood sugar during treatment with Nebupent. Nebupent can increase or decrease your blood sugar levels.

When you are taking Nebupent, it is possible that you will require regular blood tests. The function of your heart may have to be assessed by using an electrocardiograph (sometimes known as an EKG).Place unmixed medications in a cool, dry place at room temperature, away from heat, humidity, and light.

A mixture of medicines must be taken within a set amount of time based on the diluting agent. Follow the mixing instructions and storage guidelines included with your medication. Talk to your pharmacist if you have any questions.Nebupent contains no preservatives. Get rid of any medicine that has been used up.

What happens If I miss a dose?

Contact your doctor for advice in case you missed the medication Nebupent.

What happens If I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding restrictions on drinks, food, or activities.

Interaction with other drugs

Other medications can interact with pentamidine. This includes prescription and non-prescription medicines, vitamins, and herbal products. Inform your health professionals about the medicines you are taking currently and all medicines that you decide to stop or modify your use of.