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Natrol (SAMe)

Generic Name: s-adenosylmethionine (SAMe) [S– a-DEE-noe-SIL-meth-EYE-oh-neen]
The Brand Names Are: SAM-e, Natrol SAMe,
Classification of Drugs: Nutraceutical products

What is Natrol (SAMe)?

Natrol (also known as SAMe) can be described as a manufactured form of a chemical that is found naturally in our bodies.SAMe could be effective in alternative medicine to aid in the treatment of osteoarthritis.

SAMe has been utilized in alternative medicine as an efficient treatment for itching, fatigue, and abnormal laboratory tests in those suffering from an illness of the liver, as well as improving the symptoms of people suffering from depressive disorders.

Other uses that have not been proven by research include treating alcohol-related liver diseases as well as schizophrenia and aging Alzheimer's diseases, fibromyalgia, constant back pain, migraines, seizures, premenstrual syndrome, and chronic fatigue syndrome.

It isn't known for certain if SAMe works for treating medical conditions of any kind. The medical use of this drug is not recognised by the FDA. SAMe shouldn't be used to replace the medication recommended by your physician.

Same is commonly marketed as a supplement for herbal use. There aren't any regulated manufacturing standards for many herbal substances, and some of the supplements that are sold have been discovered to be infected with poisonous metals or other substances. The best herbal and health supplements are purchased from a trusted source to reduce the risk of contamination.

SAMe is also used for reasons not mentioned in this product's guide.

Side effects of Natrol (SAMe)

See a doctor immediately. If you notice symptoms that indicate an allergy, such as asthma, difficulty breathing, and swelling of your lips, face, and tongue,

Get medical attention immediately. If you experience indications associated with serotonin syndrome, which include hallucinations, agitation, sweating, fever, shivering, an increase in heart rate, muscle stiffness, or twitching, You may also experience loss of coordination, nausea, vomiting, or diarrhea.

Although not all of the side effects are well known, SAMe is thought to be safe for the majority of adults if used according to the directions.

Common adverse effects of Natrol can include:

  • Hair color changes
  • Headache, dizziness;
  • Experiencing anxiety or fear;
  • Loss of appetite, vomiting, nausea, and an upset stomach;
  • Dry mouth;
  • Diarrhea, constipation;
  • An increase in sweating increased sweating
  • Sleep problems (insomnia).

This isn't an exhaustive description of the various adverse consequences. There are other side effects that could happen. Ask your doctor for guidance on medical side effects. If you have any concerns, report them to the FDA by calling 1-800-FDA-1088.


It is not recommended to use SAMe if you suffer from bipolar disorder, anxiety disorder, or are taking medications for depression.

Don't use SAMe if you've taken an MAO inhibitor within the past 14 days. A risky drug interaction may occur. MAO inhibitors include isocarboxazid, linezolid, Methylene Blue injection, rasagiline, and phenelzine, as well as tranylcypromine and others.

Before you take this drug

SAME is not recommended. If you suffer from bipolar disorder (manic depression), anxiety disorder, or antidepressant medication.

Don't use SAMe if you've used an MAO inhibitor within the last 14 days. A potentially dangerous interaction with a drug could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, rasagiline, phenelzine, tranylcypromine, and many others.

Consult your doctor if you also take stimulant medicines, opioid medication, herbal products, or medicines to treat mental illness, depression, Parkinson's disease, migraine headaches, serious infections, or for the prevention of vomiting and nausea. An interaction with SAMe can result in a serious illness known as serotonin syndrome.

Consult a pharmacist, doctor, or any other healthcare professional about whether it is appropriate for you to take this medication when you are:

  • A planned procedure;
  • Lesch-Nyhan syndrome,
  • Parkinson's disease.

It is unknown if SAMe could harm an unborn baby. Do not use this product unless you have medical advice if you're pregnant.

SAMe is thought to be potentially unsafe to use when you are nursing the baby. Do not take this product without medical advice if you are nursing a baby.Never give a health or herbal supplement to your child without a medical recommendation.

How to Take Natrol (SAMe)?

If you are considering using SAMe, consult advice from your physician. It is also possible to consult an expert who has been trained in the use of herbal or health supplements.If you decide to use SAMe, take it as stated on the label or as recommended by your pharmacist, doctor, or any other healthcare professional. Use less than the amount of SAMe indicated by the manufacturer on its label.

SAMe is best taken with a full stomach, at least 30–60 minutes prior to a meal or two hours following eating.Consult your physician if symptoms don't improve or if they become worse.

If you are undergoing surgery, take a break from SAMe at least two weeks prior to the date of surgery.Place it in a cool, dry place far from heat and moisture.

What happens If I miss a dose?

Don't miss the missed dose, and proceed to the next dose that is regularly scheduled.

What happens If I overdose?

Get medical attention immediately or dial for help at the Poison Helpline at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any food restrictions or beverages.

Interaction with other drugs

Do not use SAMe without a medical consultation when you are taking any of the following drugs:

  • Dextromethorphan (a cough medicine, such as Robitussin D);
  • Medications that alter serotonin levels Serotonin-related drugs, for example, antidepressants, stimulants, and migraine medicine;
  • Levodopa;
  • A narcotic drug like meperidine (Demerol), pentazocine, and tramadol (Ultram, Ultracet).

This list is not comprehensive. Other medications can affect SAMe, such as medications that are prescribed and available over the counter, vitamins, and herbal supplements. Some interactions with drugs are not listed here. are included here.