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Hydrochlorothiazide and bisoprolol

Generic name: hydrochlorothiazide and bisoprolol [HYE-droe-klor-oh-THYE-a-zide-and-bi-SOE-proe-lol]
Oral tablets: (10 mg-6.25mg; 2.5 mg-6.25 mg; 5 mg-6.25 mg).
Beta-blockers with thiazides

What is Hydrochlorothiazide and bisoprolol?

Hydrochlorothiazide Is a thiazide (water pill). Bisoprolol acts as a beta blocker.Combination medicine that treats hypertension.This medication guide does not list all possible uses of hydrochlorothiazide or bisoprolol.

Side effects of Hydrochlorothiazide and bisoprolol

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to the skin (fever or sore throat with burning eyes, skin pain or blisters, or a red or purple rash that is blistering or peeling), seek emergency medical attention.

Both bisoprolol and hydrochlorothiazide can cause serious side effects. If you experience:

  • Chest pain;
  • Heartbeats that are fast, slow, or irregular;
  • A feeling of lightheadedness, as if you could pass out.
  • Blurred vision, tunnel vision, eye pain, or seeing halos around light
  • Rapid weight gain, swelling, and shortness of breath even with mild exercise;
  • Liver problems: nausea; itching; fatigue; loss of appetite; and dark urine.
  • Signs of electrolyte depletion include increased thirst or urination; constipation; muscle cramps and weakness; as well as leg cramps or numbness. Other symptoms may include feeling jittery or jittery-like, having an irregular heartbeat, or feeling choked.
  • Low sugar—headache; sweating; irritability; and dizziness. Rapid heart rate.

Some of the common side effects associated with hydrochlorothiazide or bisoprolol include:

  • Dizziness;
  • Feeling tired or weak
  • Diarrhea, nausea, and indigestion;
  • Headache

There may be other side effects. For medical advice regarding side effects, call your physician. The FDA can be reached by dialing 1-800-FDA-1088 in order to report potential incidents.

Similar/related drugs

Amlodipine, lisinopril, metoprolol, losartan, furosemide, and hydrochlorothiazide


If you cannot urinate, then you should avoid using hydrochlorothiazide or bisoprolol. Do not take hydrochlorothiazide or bisoprolol when you are suffering from a serious heart problem like "sick sinus" syndrome or "AV block", severe cardiac failure, or a slow heartbeat that has caused you to faint.

Before you take this drug

This medicine should not be used if:

  • Heart failure that is severe or uncontrollable
  • You fainted because of slow heartbeats.
  • A serious heart condition known as "sick sinus" syndrome or "AV block" (second or third degree);
  • An allergy to drugs containing sulfa.
  • If you're unable to urinate,

Inform your doctor if any of the following applies to you:

  • Congestive heart failure;
  • Asthma and other breathing disorders
  • Diabetes;
  • A thyroid disorder
  • Glaucoma;
  • Peripheral arterial disease, such as raynaud syndrome.
  • Kidney disease
  • Liver disease or cirrhosis
  • Lupus;
  • An allergy to penicillin or sulfa drugs

This medicine is not known to harm an unborn child. Inform your doctor immediately if you are pregnant, planning to become pregnant, or planning to become pregnant.This medicine should not be used while breastfeeding.The use of this medicine by those under 18 is not recommended.

How to take Hydrochlorothiazide and bisoprolol?

Read all the instructions or guides provided with your medication and follow them. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.If you have diarrhea or vomiting or are sweating more often than normal, call your doctor. It is easy to become dehydrated when taking bisoprolol and hydrochlorothiazide. This can cause very low blood pressure or a serious electrolyte imbalance, as well as renal failure.You will need to check your blood pressure often. If you are dehydrated or have vomited, your blood and urine will be tested.Check your blood sugar if you have diabetes. It may be harder to detect low blood sugar when taking bisoprolol. While you take bisoprolol and hydrochlorothiazide, your diabetes medication or insulin needs may change. You should not alter your medication schedule or dose without consulting your doctor.Tell your doctor if you are currently taking hydrochlorothiazide or bisoprolol. You may have to stop using the drug for a few days.

Doing so may worsen your condition. You should follow your doctor's advice on how to taper your dose.Even if you are feeling well, continue to take this medication as prescribed. High blood pressure is often a silent condition. Blood pressure medication may be needed for the rest of your life.Store away from heat or moisture at room temperature. When not in use, keep the bottle tightly shut.

Details on dosage

Usual Adult Dose for Hypertension:

Initial dosage should consist of 2.5 mg and 6.25 mg hydrochlorothiazide capsules taken orally once per day; to maximize effect use 20 mg and 12.5 mg capsules instead.
If you do not achieve optimal results, increase the dose by one-fourth every 14 days.
This drug can be substituted to titrate individual components.
Avoid abrupt discontinuation; taper the therapy over approximately two weeks.
If withdrawal symptoms are experienced, the therapy can be temporarily resumed.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.

What happens if I overdose?

Contact Poison Help 24/7 on 1-800-222-1222 for immediate medical attention if a poisonous substance has been taken or is suspected.Overdose symptoms include confusion, leg cramps and tingling sensations, slow heartbeats, or fainting.

What should be avoided?

Avoid alcohol. Alcohol can increase the blood levels of bisoprolol.Avoid standing up quickly from a seated or lying-down position. You may feel dizzy. To avoid a fall, get up slowly.The use of hydrochlorothiazide can increase your risk of skin cancer. Avoid tanning beds or sunlight. When you're outdoors, wear protective clothing and use sunblock with an SPF of 30 or more. You may be asked to undergo regular skin checks by your doctor.

Interaction with other drug

Tell your doctor about your other medications, including:

  • Cholestyramine or colestipol
  • Insulin or oral diabetes medication;
  • Lithium;
  • Sedatives and narcotic medicines
  • Heart or blood pressure medicines: clonidine (dioxin), diltiazem (disopyramide), reserpine (reserpine), verapamil, and others
  • Aspirin, naproxen, celecoxib (advil), diclofenac (indomethacin), meloxicam, and other nsaids
  • Prednisone, among others.

This list is incomplete. Hydrochlorothiazide, bisoprolol, and other drugs can interact with each other. This includes prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible drug interactions.