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Generic Name: Mavacamten [MAV-a-KAM-ten].
The Brand Name: Camzyos.
Dosage Form: Oral capsule (10 mg; 15 mg; 2.5 mg; 5 mg).
Drug Class: Miscellaneous cardiovascular agents.

What is Mavacamten?

Mavacamten is used by older adults to treat an issue known as obstructive hypertrophic cardiomyopathy (HCM). Mavacamten can help improve people's symptoms as well as their capacity to stay active. Mavacamten is only available from a licensed pharmacy under the program of a specific one. You must be enrolled in the program and be aware of the potential risks as well as the benefits associated with this drug. Mavacamten can also be used to treat conditions not covered in this medication guide.

Side effects of Mavacamten

See a doctor immediately. If you are experiencing warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, and tongue. Mavacamten may cause serious side effects. Contact your doctor immediately. If you suffer from:

  • Heart failure symptoms include the feeling of breathing becoming short, chest pain, fatigue, swelling of your legs, fast weight gain, or pounding or racing heartbeats.

Common side effects of mavacamten include:

  • Dizziness.
  • Fainting.

This isn't an exhaustive list of possible side effects, and other effects may also be present. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Contact your doctor immediately for any symptoms such as shortness of breath or chest pain, fatigue, swelling of your legs, rapid weight gain, or heartbeats that are racing or pounding.

Before you take this drug

Certain medications should not be used in conjunction with mavacamten. Your treatment regimen may be altered when you are also using:

  • John's wort.
  • An antibiotic—clarithromycin, rifabutin, rifampin, rifapentine, telithromycin.
  • Antifungal medicine (itraconazole, ketoconazole).
  • Antiviral medication used to treat HIV as well as hepatitis C—boceprevir and cobicistat, dasabuvir, elvitegravir and indinavir, lopinavir/ritonavir, paritaprevir, ombitasvir, saquinavir, and telaprevir. Tipranavir is also available.
  • Cancer medicine—apalutamide, enzalutamide, and mitotane.
  • Seizure medicine—carbamazepine, oxcarbazepine, phenytoin, primidone.
  • Steroid medicine—dexamethasone, prednisone.

Inform your doctor immediately if you experience symptoms that indicate such problems:

  • An unsteady heartbeat, an irregular heartbeat.
  • If you suffer from an infection.

Mavacamten could harm a newborn. You may need an ultrasound test to be sure you're not pregnant. Utilize effective contraception when using mavacamten and for a minimum of 4 months following your last dose. Inform your doctor if you become pregnant. Check with your doctor to get advice on whether it is safe to breastfeed during mavacamten. Mavacamten may make the birth control pill less efficient. Consult your physician about other birth control options, such as implants, injection patches for the skin, vaginal ring condoms, diaphragm cervical caps, and contraceptive swabs.

How To Take Mavacamten?

Follow the directions on the prescription label and go through all medication guides or instruction sheets. Follow the medication exactly as prescribed. Speak to your doctor prior to making any changes to your medication. It is recommended to have an echocardiogram prior to and during treatment with mavacamten. Do you take Mavacamten every day?

Suck the capsule whole, but don't crush, chew, break, tear, or even crack it. The treatment you receive may be delayed or discontinued permanently in the event of adverse reactions. Place it in a cool, dry place far from heat and moisture.

Details on dosage

Usual Adult Dose for Hypertrophic Cardiomyopathy:

The recommended starting dose is 5 mg, taken orally every day.
Dosages that can be repeated that are titrated: 2.5, 5, 10, or 15 mg orally every day
Comments:Heart failure is a possibility for patients during treatment with this drug. Regular left ventricular efficacy (LVEF) as well as Valsalva left ventricle outflow tract (LVOT) gradient evaluation is required for a careful adjustment of the goal Valsalva LVOT gradient while keeping LVEF at or near 50 percent and avoiding heart disease symptoms.
When initiating or titrating the dosage of this drug, LVEF must be first considered, and then the LVOT gradient of Valsalva and the clinical state of the patient must be taken into consideration to determine the appropriate dosage. The algorithms for initiation and maintenance must be used to determine the appropriate dosage as well as monitoring regimens.
If LVEF is lower than 50% in the course of therapy, this medication should be stopped, and the protocol for interruption is to be followed to get instructions on stopping, restarting, or discontinuing this medication. If it is interrupted at 2.5 mg, patients should start again with 2.5 mg or discontinue the drug permanently.
Use: To treat patients suffering from symptomatic New York Heart Association (NYHA) class II to III hypertrophic obstructive cardiomyopathy (HCM) to enhance functional capacity and reduce symptoms.

What happens if I miss a dose?

You should take the medication as quickly as you are able, but do not take any missed doses if it's close to the time of the next dose. Don't take two doses at a time

What happens if I overdose?.

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Grapefruit can react with mavacamten, causing negative side effects. Avoid consuming grapefruit products.

Interaction with other drugs

Discuss with your doctor any other medications you take, particularly:

  • Other medications to treat the condition of obstructive hypertrophic cardiomyopathy.
  • Omeprazole, esomeprazole, or cimetidine.

This list isn't exhaustive. Other medications can affect mavacamten, such as prescription and over-the-counter medicines, vitamins, and herbal supplements. Some interactions with drugs are not listed here. are listed here.