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Generic Name: Procarbazine Procarbazine pro-CAR ba-zeen Pro-CAR-bazeen.
Classification of Drugs: Miscellaneous antineoplastics.

What is Matulane?

Matulane is a drug that is prescribed along with other cancer drugs for the treatment of Hodgkin's disease (a form of cancer that affects blood vessels). Matulane can also be employed for other purposes that are not covered in this guideline.

Side effects of Matulane

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, and swelling of your lips, face, and tongue. Matulane may cause serious side effects. Contact your physician immediately in the event of:

  • Diarrhea, which is a liquid.
  • Numbness, burning pain, or tingling sensation.
  • Hallucinations, confusion, issues with speech or vision, problems with walking, or everyday tasks.
  • Being unsteady, loss of balance, or coordination.
  • Tremors, seizures.
  • Cough, chest discomfort, trouble breathing.
  • The appearance of blisters or ulcers inside your mouth; swollen or red gums; difficulty swallowing.
  • The stool is bloody or tarry, coughing up blood, or vomiting that resembles coffee grounds.
  • Digestive problems, such as a loss of appetite, nausea, stomach discomfort (upper right side), fatigue, itching, dark urine, stools that are clay-colored, jaundice (yellowing of the eyes or skin).
  • Low blood cell count Low blood cell counts: fever, chills, achy bleeding, unusual bruising, white skin, cool feet and hands, feelings of being lightheaded or breathless.

Common adverse effects of Matulane could include:

  • Low blood cells Low blood cell counts.
  • Nausea, vomiting.

This is not a comprehensive list of all the possible adverse reactions. Other side effects could be present. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Matulane may increase the chance for bleeding or infections. Consult your physician if you notice unusual bleeding or bruising or if you notice new symptoms of infection (fever, chills, achy mouth sores, pale skin).

Before you take this drug

You shouldn't use Matulane if you are allergic to it or if you suffer from bone marrow suppression. Speak to your doctor if you have ever suffered from:

  • kidney disease.
  • The liver condition.
  • Anemia (low red blood cells).
  • The platelets are low in the blood.
  • Low white blood cell count.
  • Fluid retention.
  • If you've received any other radiation or chemotherapy in the last 30 days.

Matulane can harm a newborn baby. Use effective birth control to stop pregnancy and inform your physician if you are pregnant. Matulane could influence fertileness (the ability to have children) for men. Do not breastfeed when you take Matulane.

How to take Matulane?

Please follow the directions on your prescription label and review all medication guides and instructions carefully. Make sure you use the medication precisely as directed. Matulane could increase your chances of contracting an infection or bleeding. It is recommended to undergo regular medical tests. The treatment for cancer may be delayed depending on the findings of these tests. Maintain at room temperature, free of heat, moisture, and light.

What happens if I miss a dose?

Do not take the medicine for as long as you can. However, do not take your missed dose if it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222. The symptoms of an overdose could include diarrhea and vomiting, as well as tremors or feeling lightheaded.

What should be avoided?

Don't drink or consume alcohol. Unpleasant side effects may be experienced. Beware of those who are sick or suffering from infections. Contact your doctor right away in the event that you show symptoms of an infection. Do not get a "live" vaccine while using Matulane. The vaccine might not function effectively and could not fully protect you against illness. Live vaccinations comprise measles, rubella, mumps (MMR), and rotavirus. yellow fever, typhoid varicella (chickenpox), zoster (shingles), and the nasal influenza (influenza) vaccine.

Beware of eating foods high in tyramine. This includes:

  • Avocados, bananas, figs, raisins, papaya, and sauerkraut.
  • Dried and aged meats.
  • Beers on tap; wine (not in bottles or cans).
  • Aged cheeses, which include blue Brie, Boursault, and brie camembert cheese; cheddar; gruyere mozzarella; parmesan Romano; Roquefort; and Swiss.
  • Miso soup, soy sauce, and bean curd.
  • Yeast extracts, and yogurt.

Tyramine consumption while taking Matulane could raise blood pressure and cause dangerous levels of hypertension, which can lead to serious side effects. Do not smoke while you are undergoing treatment. Smoking could increase your chance of developing lung cancer when you take Matulane.

Interaction with other drugs?

Making use of Matulane together with other medications that cause drowsiness can increase the severity of this effect. Talk to your doctor prior to using opioids, a sleeping pill, a muscle relaxer, or medication to treat anxiety as well as seizures.

Inform your doctor about all other medications, including:

  • Blood pressure medicine.
  • An antidepressant or sedative.
  • Stimulants, diet pills, and ADHD medications like Adderall and Ritalin.
  • Medicine for treating psychosis or mental disorders. psychosis.

This list isn't exhaustive. Other medications can impact Matulane, such as prescription and over-the-counter drugs, vitamins, and herbal products. There are many possible interactions between drugs that are included here.