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Name of the Generic: Maralixibat .
Brand Name: Livmarli.
Dosage Format: Oral solution (9.5 mg/mL).
Drug Class: Miscellaneous GI agents.

What is Maralixibat?

Maralixibat helps to relieve itching caused by liver issues in those who suffer from an inherited condition known as Alagille syndrome. People with this condition don't have enough ducts to eliminate the bile-like fluid from the liver. This can cause liver damage when bile builds up within the liver. Maralixibat is a treatment for itching related to the liver. Maralixibat isn't an effective treatment or cure for Alagille syndrome. Maralixibat could also be used to treat conditions not covered in this medication guide.

Side effects of Maralixibat

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and throat. Maralixibat can cause severe adverse effects. If you have any of the following symptoms, please contact your doctor right once:

  • Severe ongoing nausea, vomiting, or diarrhea.
  • Stomach pain, diarrhea that's bloody.
  • The sudden pain or difficulty in getting your leg, arm, or shoulder.
  • Issues with the liver: loss of appetite, stomach discomfort (upper right side), Itching, fatigue, and dark urine; a stool colored by clay; jaundice (yellowing of the eyes or skin).
  • Dehydration—dizziness, confusion, feeling very thirsty, less urination.
  • Stomach bleeding—bloody or tarry stool and coughing up blood, or vomit that appears like coffee grounds.

Common side effects of maralixibat can include:

  • Stomach pain, vomiting, and diarrhea.
  • Stomach bleeding.
  • A lack of fat-soluble vitamins (vitamins A, D, E, and K) as well as.
  • Unusual liver function tests.

This is not an exhaustive list of probable adverse effects; other negative effects may arise. Contact your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Take only according to the directions. Inform your doctor if you take other medications or suffer from any other medical condition or allergies.

Before you take this rug

Speak to your doctor if you have ever suffered from the condition known as cirrhosis. Maralixibat may make it more difficult for the body to absorb certain vitamins that you might require more during your pregnancy or while nursing. Follow your doctor's advice on taking any vitamin supplement when you are nursing or pregnant. Maralixibat shouldn't be given to children older than 1 year.

How to take Maralixibat?

Follow the directions on the prescription label and study all medication guides or instruction sheets. Your doctor may change the dosage. Follow the medication exactly as prescribed. Maralixibat is typically taken once every day, approximately 30 minutes prior to eating. Follow the doctor's instructions for dosage extremely carefully. Use the measuring device supplied (not the kitchen spoon).

You'll need frequent blood tests to determine your liver's functioning. Your doctor may ask you to take a specific vitamin supplement when you take maralixibat. Only take the kind and quantity your doctor has advised. Close tightly at room temperature, away from heat and moisture. Dispose of any unopened Maralixibat liquid after 45 days from the time you opened the bottle for the first time. Talk to your pharmacist about a take-back program. It is also possible to mix the remaining medicine with coffee grounds or cat litter in a sealed plastic bag and then throw it in the garbage.

What happens if I miss a dose?

Take the medication as quickly as you are able, but do not take your missed dose if you have been more than twelve hours late for the dose. Do not take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or activities

Side effectsof maralixibat

Does your maralixibat dosage 4 hours prior to or 4 hours following the time you take or are taking any other of the following medications:

  • Colesevelam.
  • Colestipol.
  • Cholestyramine.

Discuss with your doctor the other medications you take, including those that are statin cholesterol medicines such as simvastatin, atorvastatin, lovestatin, rosuvastatin, Crestor, Lipitor, Zocor, and many more. Other drugs can interact with maralixibat as well, including prescription and over-the-counter medicines, vitamins, and natural products. Discuss with your physician all other medications you are taking.