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Makena

Generic Name: Hydroxyprogesterone injection [hye-DROX-ee-pro-JES-te-rone].
Drug Class: Progestins.

What is Makena?

Makena is a type of progesterone. It is a synthetic female hormone known as progesterone. Makena can be used to decrease the chance of having a premature birth for a woman who already has a premature child. Makena does not prevent premature birth, which is already beginning. Makena is not recommended for women who are expecting more than a single child (twins, triplets, etc.). Hydroxyprogesterone can also be employed for other purposes that are not covered in this medication guide. There is no evidence that the Makena brand name has been removed across the U.S. If the generic versions of this product are approved by the FDA, there may be substitutes that are similar to the original.

Warnings

Makena is not advisable to take if you suffer from uncontrolled hypertension, vaginal bleeding that is unusual, liver disease, cancer, jaundice caused by pregnancy, or if you have previously had problems with circulation such as a stroke or blood clot, as well as cancers that affect the breast, the uterus, the cervix, or the vagina. Your doctor will examine your health regularly during your treatment with Makena. Don't fail to attend any scheduled appointment. Each woman must be under the supervision of a physician during pregnancy. Contact your doctor immediately in the event of sudden weakness or numbness, confusion, difficulties with speech or vision, jaundice (yellowing of the eyes or skin) or swelling of your feet or hands, as well as redness or pain in each leg, and signs of depression (sleep issues and mood fluctuations). There are many other medications that could interfere with Makena. Inform your doctor about any medications you are currently taking. This includes prescriptions, over-the-counter vitamins, herbal products, and other products.

Do not begin an unprescribed medication during pregnancy without talking to your doctor.

Before you take this drug

It is not recommended to treat Makena. If you have an allergy to hydroxyprogesterone or casting oil or are:

  • Vaginal bleeding is unusual and not a sign of pregnancy.
  • Extreme or uncontrolled blood pressure.
  • Cancer of the liver.
  • It is a sign of pregnancy if you have jaundice.
  • A history of cancer in the breast, around the uterus, cervix, or vagina.
  • A history of blood clots, strokes, or problems with circulation.

Makena is not permitted to be used by anyone younger than 16 years old. Inform your healthcare if you have ever beared:

  • Preeclampsia, eclampsia, or preeclampsia.
  • kidney disease.
  • Heart disease and high blood pressure.
  • Migraine headaches.
  • Diabetes (in the relatives members).
  • Epilepsy or another seizure.
  • Asthma
  • Depression.

It's not clear if Makena will help prevent any medical problems for newborn babies. Discuss with your doctor the risk your baby is at.

How to take Makena?

Makena is injected beneath either the skin or muscle. The healthcare professional will administer the injection. The initial Makena injection is usually administered in the second trimester of pregnancy. The typical dosage is one injection a week up to the 37th week, or when the child is born. Follow the instructions of your doctor. Your doctor will examine your performance regularly. Make sure you don't skip any scheduled appointments. Every woman should be under the supervision of a medical professional during her pregnancy.

Details on dosage

Usual Adult Dose for Premature Labor:

To decrease the risk of premature birth for women who have an unintended pregnancy and an antecedent of spontaneous singleton preterm births:
250 mg intramuscularly, once a week.
Start the treatment between 16 weeks, 0 days, and 20 weeks, six days pregnant. Keep the treatment going once a week up to week 37 (through 36 weeks or up to 6 days) of gestation or until the time of delivery or birth, whichever is first.

Usual Pediatric Dose for Premature Labor:

To decrease the chance of preterm birth in women who are having one-to-one pregnancies and who have a history of spontaneous singleton preterm births:
at least 16 years old:
250 mg intramuscularly, once a week.
Start treatments between the ages of 16 weeks and between 0 and 20 weeks of six-day gestation. Keep the treatment going once a week up to week 37 (through 36 weeks or up to 6 days) of gestation or until the time of delivery or birth, whichever is first.

What happens if I miss a dose?

Contact your doctor for advice in the event that you don't make an appointment to receive the Makena injection.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Side effects of Makena

See a doctor immediately. If you are experiencing symptoms of an allergy reaction, Makena: hives or itching; difficulty breathing; swelling of yobreathingface, and tongue.

See your doctor right away. If you suffer from:

  • Bleeding, swelling, oozing, or worsening pain at the site where the injection was administered.
  • Signs of depression (sleep problems, apathy, mood changes).
  • Swelling in your ankles, hands, or feet.
  • Elevated blood pressure, extreme headaches, blurred vision, and pounding in your neck and ears. tension, nosebleeds.
  • Indications for a blood clot: sudden weakness or numbness in vision, difficulty with speech, redness or swelling in the arm or leg.

Common Makena side effects can include:

  • Itching, swelling, pain, an itch, rash, or lump that was injected.
  • Nausea.
  • Diarrhea.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications may interfere with hydroxyprogesterone. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your doctor about the medicines you are currently taking as well as any medications you are about to start or stop taking.