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Isosorbide dinitrate

Generic Name: Isosorbide dinitrate [EYE-soe-SOR-bide-dye-NYE-trate]
Names of brands: Isochron, Isordil Titradose, Sorbitrate, Dilatrate-SR, Isordil, ISDN, and Isordil Tembids
Dosage Formats: Oral tablet (10 mg; 20 mg; 30 mg; 5 mg; 40 mg) Oral tablet, longer release (40 mg)
Drug Class: Antianginal agents

What is Isosorbide dinitrate?

Isosorbide dinitrate is a nitrate that dilates (widens) blood vessels, which makes the circulation of blood more efficient and easier for the heart to pump.Isosorbide dinitrate is used to prevent or treat chest pain (angina).The sublingual tablet should be used for treating angina attacks that have already started.

Isosorbide dinitrate extended-release and regular tablets are used to stop angina attacks, but they do not treat angina attacks.Isosorbide dinitrate could also be used for other purposes that are not mentioned in this guide.

Side effects of Isosorbide dinitrate

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergy, such as symptoms of hives, breathing difficulties, and swelling of your lips, face, and tongue,

Isosorbide dinitrate may cause serious side effects. Consult your doctor immediately in the event of:

  • A feeling of lightheadedness, as if you're about to pass out.
  • Worsening angina pain;
  • Heart rate, either a fast heart rate or a low heart rate,
  • The beat of your heart is pounding or fluttering inside your chest.

Isosorbide dinitrate can cause severe headaches. These headaches could slowly diminish in severity as you continue taking the nitroglycerin. Do not stop taking isosorbide dinitrate to prevent headaches. Talk to your doctor prior to taking medication for headaches. medicine for pain.

Common side effects could be more likely to happen, for example:

  • Headaches
  • Flushing (warmth of redness, warmth, or a tingly sensation).

This isn't a complete list of possible side effects, and other effects may also be present. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


You shouldn't use erectile dysfunction medications (Viagra, Cialis, Levitra, Stendra, Staxyn, Sildenafil, Avanafil, Tadalafil, and Vardenafil) in conjunction with isosorbide dinitrate. Combining these medications could result in an abrupt and significant drop in blood pressure.

Get emergency medical attention when you notice the first signs of a heart attack (chest pressure, pain that is spreading to your shoulder or jaw, sweating, general ill-feeling).

Before you Take this Drug

It is not recommended to use isosorbide dinitrate in the following situations:

  • You are allergic to isosorbide dinitrate, isosorbide mononitrate, or nitroglycerin.
  • There are early warning symptoms if you are experiencing early signs of a heart attack (chest pressure or pain or pain that spreads to your shoulder or jaw, nausea, sweating).

It is not recommended to use erectile dysfunction medications (Viagra, Cialis, Levitra, Stendra, Staxyn, Sildenafil, Avanafil, Tadalafil, or Vardenafil) when you are taking isosorbide dinitrate. Combining these medications can result in a sudden, significant drop in blood pressure.

To be sure that isosorbide dinitrate is not harmful to you, consult your physician to determine whether you suffer from:

  • Congestive heart failure;
  • Kidney disease
  • Low blood pressure.

It isn't known if isosorbide dinitrate can cause harm to a baby who is not yet born.Contact your doctor if are expecting or plan to have a baby.

It is unclear if isosorbide diamine enters the breast milk or if it can affect nursing babies. Inform your doctor if you are breastfeeding.

How to Take Isosorbide dinitrate?

If you are considering using isosorbide dinitrate to treat sudden angina attacks, Your doctor might advise you to first try a nitroglycerin tablet sublingually. Follow the instructions of your physician on the medications you should take in the event of an attack and how long to wait between doses.

Follow the directions on the prescription label. Your doctor might change the dosage. Be sure to not take this medicine in greater or lesser amounts or for longer periods than prescribed. If you are taking excessive amounts of isosorbide dinitrate, it may not work as well to control your condition.

Make sure to take a break or remain in a comfortable place when taking this medication (it may cause dizziness and falls).To help prevent attacks of angina Isosorbide dinitrate is typically administered at regular intervals.

In order to treat angina attacks that have already started, you should take the medicine immediately upon the first onset of chest discomfort.The tablet should be placed on your tongue, and allow it to dissolve gradually. Don't chew or swallow it.You can take the sublingual tablet 15 minutes prior to any activity that you believe could cause chest discomfort. Follow your physician's advice.Do not chew, crush, break, open, or crush the extended-release tablet or capsule. Take it in whole.

Follow your doctor's dosage instructions extremely carefully. If your physician changes the strength, brand, or kind of isosorbide dinitrate, your dosage requirements could be altered. Talk to your pharmacist if you have any concerns about the new type of isosorbide dinitrate available at the pharmacy.

Contact emergency medical assistance. If the chest pain becomes worse or lasts more than five minutes, particularly in the event that you experience difficulty breathing or are feeling faint, dizzy, lightheaded, or nauseated.

It is possible that you have low blood pressure when you take this medication. Consult your doctor if you are suffering from nausea or diarrhoea or have more sweating than usual. Long-term illness may result in a serious electrolyte imbalance, which makes it risky to use isosorbide diuretics.

If you are taking isosorbide dinitrate regularly on a schedule to avoid angina, be sure not to stop it suddenly, or you could suffer from an attack of severe angina. Keep this medicine in your pocket at all times. Refill your prescription prior to the time you get rid of the medicine completely.

Keep the bottle. the bottle at room temperature, far from heat, humidity, and light. Make sure the bottle is tightly sealed when not being used.

What Happens If I Miss a Dose?

Because isosorbide dinitrate can be utilised only when it is necessary, it is possible that you are not on a schedule for doses. If you're following a regimen, you should take the dose you missed as quickly as you can. Do not miss your missed dosage if the dosage is a little less than two hours from now.

If you're taking the extended-release tablet or capsule with a dose less than six hours away, you should skip the missed dose and take the medication at the next scheduled time.

Do not take extra medication to fill in the missed dose.

What Happens If I Overdose?

Get medical attention immediately. If you believe you've taken too much isosorbide dinitrate, A high dose of isosorbide dinitrate could cause death.

Overdose symptoms can include an intense, throbbing headache, fever, confusion, extreme dizziness, pounding or fast heartbeats, visual problems, nausea, vomiting, stomach bleeding, bloody diarrhoea, sweating, difficulty breathing, cold or dry skin, fainting, and seizures (convulsions).

What Should be Avoided?

This medication could impair your reactions or thinking. Be aware if you are driving or engaging in any activity that requires you to be aware. Do not get up too fast from a lying or seated position, as you may be dizzy. Begin slowly, and then steady yourself so that you don't fall.

Do not drink alcohol. Alcohol can cause the effects of isosorbide dinitrate (dizziness, drowsiness, feeling lightheaded, and fainting).

Interaction with Other Drugs

Isosorbide dinitrate taken in conjunction with other medications could result in severely reduced blood pressure. This includes medicines to treat erectile dysfunction and high blood pressure in the pulmonary veins. A life-threatening and serious adverse reaction could be experienced.

Inform your doctor about all the medicines you are currently taking and all you are about to start or stop using, in particular:

  • Avanafil (Stendra);
  • Diuretic, also known as a "water pill";
  • Nitroglycerin;
  • Riociguat (Adempas);
  • Sildenafil (Viagra, Revatio);
  • Tadalafil (Cialis, Adcirca) (Cialis, Adcirca)
  • Vardenafil (Levitra, Staxyn).

This list isn't complete. Other medications can interact with isosorbide dilute, which includes prescription and over-the-counter medications, vitamins, and herbal products. There are many possible interactions that are not included in this guideline for medication.



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