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Generic name: benzoyl peroxide and hydrocortisone topical [BEN-zoyl-per-OX-ide-and-HYE-droe-KOR-ti-sone-TOP-i-kal]

Drug class: Topical acne agents

What is Vanoxide-HC?

Vanoxidehc (for the face) is a combination of antibacterial and steroid medication that is utilized to manage acne.Vanoxide-HC can also be used for reasons not mentioned in this medication guide.

Side effects of Vanoxide-HC

Stop taking Vanoxide-HC and seek medical attention immediately in the event that you exhibit indications of a serious allergic reaction or serious skin irritation that include an allergic reaction, itching and breathing difficulties, feeling lightheaded, and swelling of your tongue, face, lips, or throat.

The reactions can occur within a few minutes after applying the medication and may last for a few hours or more afterward.

This medication could cause severe adverse consequences. Stop taking this medicine and consult your physician immediately if you suffer from:

  • Extreme burning, stinging, or redness on treated skin
  • Extreme itching or irritations to the skin;
  • Indications of signs of a skin infection—warmth, redness, swelling, and redness. You may also notice oozing or a crusting appearance around the hair follicles.

Your skin may be able to absorb hydrocortisone and cause side effects from steroid medication throughout your body. Stop taking this medication and consult your physician in the event that you suffer from:

  • Weight increase (especially around your face or in your upper back, the torso);
  • Slow wound healing time, thinning skin, and more body hair
  • Irregular menstrual cycles or changes in the sexual function,
  • Muscle weakness, fatigue, anxiety, and feeling angry

Children may adsorb greater amounts of this medication through their skin and could be more likely to suffer negative side effects.

Common negative side effects of vanoxide-HC could include:

  • Small stinging or burning (especially the first time you apply this medicine to your neck or any other skin-sensitive areas);
  • The sensation of itching or tingling;
  • Dry skin, peeling, or flaking
  • Mild irritation or redness.

This list does not represent all possible side effects; other issues could occur. Please consult your physician if any adverse reactions appear; alternatively you can report any incidents directly to the FDA at 1-800-FDA-1088.

Similar/related drugs

Doxycycline, metronidazole topical, Clindamycin topical, topical erythromycin, Ivermectin topical, Tetracycline, and Brimonidine topical


Benzoyl peroxide could cause a rare but serious allergic reaction or extreme itching. Stop using this medication and seek emergency medical attention if you experience symptoms like itching, hives, difficulty breathing, feeling lightheaded, or swelling of your lips, face, and throat.

Before you take this drug

It is not recommended to take Vanoxide-HC if you are sensitive to benzoyl peroxide or hydrocortisone or are suffering from

  • A viral or fungal skin infection.

Inform your physician if you have ever experienced:

  • Any skin condition that is not acne
  • Extremely sensitive skin;
  • Allergies;
  • The condition diabetes;
  • Issues with your adrenal gland.

Consult with your physician if you are breastfeeding or pregnant.Do not administer this medicine to a child unless you have medical guidance.

How to take Vanoxide-HC?

Benzoyl peroxide may cause a serious but rare allergic reaction or severe skin discomfort. Before you start using this treatment, it is possible to apply the "test dose" to see the severity of the reaction. Apply a small amount of the medication to one or two small spots of acne each day for three consecutive days. If there's no reaction, apply the full dose after the fourth day.

Follow the instructions on the prescription label and review all medication guides and instructions sheets. Follow the medication precisely as directed.

Do not consume by mouth. Topical medicine should be used solely on the skin. Do not apply it to open wounds, sunburned, windburned, or irritated skin. Avoid using it in areas with the condition known as eczema. It is best to wait until the condition has improved before using this medication.

Take note of and follow the instructions for use that come along with your medication. Consult your physician or pharmacist if you don't understand the instructions.You might have to shake the medication at least prior to every use.Clean your hands before or after using the medication.Cleanse and dry the skin that is to be treated. Apply the medication in a thin layer and massage gently.

Don't cover the treated skin area unless the doctor advises you to.Benzoyl peroxide is a bleaching agent that can be used to treat other fabrics. Beware of allowing this product to get into the hair on your clothes.Contact your physician if your symptoms don't improve or if they become worse.Store at room temperature and avoid freezing. Close the bottle when not being used.

Discard any vanoxide-HC that is not utilized within 3 months from the date you purchased this medication from an online pharmacy.

What happens if I miss the dose?

Apply the medicine as fast as you are able, but avoid the missed dose if you think it is close to time for the next dose.Do not administer two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help Line at 1-800-222-1222 in the event that anyone has swallowed the medicine accidentally.

A high dose of topical steroid medication isn't likely to trigger life-threatening symptoms. The long-term use of high doses may result in thin skin easily bruising, changes in the body's fat (especially around your neck, face back, waist, and face), a rise in facial hair or acne, menstrual disorders, impotence, or a loss of interest in sexual activity.

What should be avoided?

Rinse your eyes with water if vanoxidehc is found in your mouth, eyes, or in the vicinity of your genitals.

Avoid using products for skin that can cause irritation, like harsh shampoos, soaps, hair coloring products, or permanent chemicals such as waxes or hair removers, or skin care products that contain alcohol, astringents, spices, or lime.

Interaction with other drug

Making use of tretinoin applied topically (Retin-A, Renova, and others) along with a medication containing benzoyl peroxide can create severe skin irritation.

Skin care products are unlikely to be affected by any other medications that you are taking. However, many medications can interact with each other. Be sure to inform your health care professionals about any medications you take, such as prescription and over-the-counter drugs, vitamins, and herbal remedies.