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What is Inotuzumab-ozogamicin (IGO)?
Inotuzumab is a monoclonal antibody that's linked to a chemotherapy medication. A monoclonal antibody is made to destroy and target only specific cells within the body. This could help protect healthy cells.
Inotuzumab-ozogamicin can be used to treat certain types of acute leukemia that have returned or not responded to prior chemotherapy.This medication guide does not list all possible uses of Inotuzumab.
Side effects of Inotuzumab ozogamicin
If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: difficulty breathing, hives, swelling of your lips, face, tongue, or throat.
Some side effects can occur immediately after or during the injection. You should tell your carer if you experience a cold, itchiness, fever, or are short of breath. These symptoms can also appear up to one hour after receiving your inotuzumab-ozogamicin shot.
Inotuzumab ozogamicin may cause serious side effects. If you experience:
- Symptoms of the cold or flu
- Difficulty breathing;
- Swollen gums, mouth sores;
- Pale skin, skin sores, and easy bruising
- A headache accompanied by severe dizziness and chest pain, fainting, or rapid heartbeats
- Signs of liver disease include upper stomach pain, jaundice, rapid weight gain, or swelling of your arms or legs.
- Unusual bleeding—bleeding gums or abnormal vaginal bruising, blood in urine or stools, or bloody vomit or phlegm that looks like coffee ground
If you experience certain side effects, your cancer treatment may be delayed or discontinued permanently.
Inotuzumab-ozogamicin can cause a number of side effects.
- Fever;
- Feeling tired
- Nausea, stomach pain;
- Headache
- Abnormal laboratory tests
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Warnings
Inotuzumab-ozogamicin can cause severe or even life-threatening liver issues, including veno occlusive disease.
Call your doctor if you notice any of the symptoms.
Before you take this drug
Inform your doctor if you experience any of the following symptoms:
- Liver problems
- A stem cell transplant is performed.
- Long-QT syndrome
- An electrolyte imbalance can occur when there is a low level of magnesium or potassium in the blood.
Before starting the treatment, you may need a negative pregnancy result.Inotuzumab can harm an unborn child. To prevent pregnancy, use effective contraception while taking this medicine. Whether you are a woman or a man, Men should use condoms. Inotuzumab-ozogamicin can cause birth defects if either parent uses it.
If you're a woman, continue to use birth control for at least eight months after the last inotuzumab dose. Men should continue to use condoms at least five months after their last dose. If you become pregnant while using inotuzumab, tell your doctor immediately.
Both men and women may be affected by this medicine. It is still important to use birth control to avoid pregnancy, as inotuzumab can harm the child if it does happen.Do not breastfeed for 2 months following your last dose of this medication and while you are taking it.
How to take Inotuzumab?
Inotuzumab is infused into the vein. This injection will be given by a healthcare provider.Other medicines may be prescribed to prevent the side effects of inotuzumab. These medicines should be taken for the prescribed time.Inotuzumab is administered in cycles of 21 or 28 days. It may be necessary to take the medication only on certain days during each cycle. Inotuzumab is prescribed by your doctor for a specific period of time.
Inotuzumab may cause serious liver problems or even death, such as veno-occlusive diseases (blocked vessels in the liver, which can lead to damage to the liver). You will need to have your liver function checked.
Inotuzumab can also suppress your immune system. You may develop an infection or bleed easily. You will have to test your blood frequently. The results may delay your cancer treatment.Electrocardiograms (also called ekgs) are used to check the heart's function.
What happens if I miss the dose?
If you are unable to attend your appointment for inotuzumab-ozogamicin, call your doctor.
What happens if I overdose?
Inotuzumab is administered by a health professional in a medical environment, so an overdose is unlikely.
What should be avoided?
If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.
Interaction with other drug
Inotuzumab can cause serious heart problems. This risk is higher if you are also taking other medications for asthma, depression, mental illness, or cancer.
Inotuzumab may be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.