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Excedrin Migraine

Generic Name: Acetaminophen and Caffeine [a-SEET-a-MIN-oh-fen and KAF-een] 

Brand Names: Excedrin Mild Headache, Excedrin Quick Tab Peppermint and Excedrin Quick Tab Spearmint are popular choices; Excedrin Tension Headache Caplet Express Gels Gel Tab are other options available to treat tension headaches.

What is Excedrin Migraine?

Acetaminophen can help alleviate pain and lower fever. Acetaminophen can be used to reduce fever and as a pain reliever. Aspirin belongs to a class of drugs known as salicylates. It reduces substances that are responsible for pain, fever, and inflammation. Caffeine stimulates the central nervous system. It improves blood flow by relaxing muscle contractions within blood vessels.Excedrin Migraine treats tension headaches and migraine headaches.Aspirin should not be used for blood vessels or heart conditions unless you are told to by your doctor.

Side effects of Excedrin Migraine

If you experience any of the following symptoms of an allergic reaction: itching; difficulty breathing; swelling on your face, lips, or tongue; or if you are having trouble breathing, seek emergency medical attention.Acetaminophen can cause severe skin reactions that are fatal. This may happen even if you've taken it before and never had a reaction. Call your doctor immediately if you experience skin redness, blistering, or peeling.

Call your doctor immediately if:

  • Severe anxiety, agitation, confusion, and panic;
  • Easy bruising and bleeding
  • A feeling of lightheadedness, as if you could pass out.
  • If you are feeling very hot or thirsty, unable to urinate, and experiencing heavy sweating, or if your skin is hot and dried, then this may be the cause.
  • Symptoms of stomach bleeding: bloody or tarry stool, vomiting blood or coffee-like vomit;
  • High potassium: slow heart rate, weak pulse, and muscle weakness;
  • Liver problems: nausea, upper abdominal pain, itching, and loss of appetite. Dark urine, clay-colored stools, and jaundice

Some of the most common side effects associated with Excedrin Migraine include:

  • Heartburn, stomach ache
  • Feeling anxious, restless, or depressed?
  • Sleep problems (insomnia).

There may be other side effects. For medical advice on side effects, call your doctor. Contact the FDA by dialing 1-800-FDA-1088 in order to report side effects.


Excedrin Migraine should not be given to children or teens with flu symptoms or chicken pox. Aspirin may cause Reye syndrome in children, which can be fatal.Excedrin Migraine should not be taken in excess.Acetaminophen can cause severe skin reactions that are sometimes fatal, even if you have taken it before without experiencing adverse side effects. This could happen even if it wasn't intended as such!clay-colored stools, or jaundice.Aspirin can cause fatal stomach or intestinal bleeding. If you experience symptoms like bloody or tarry stool, vomiting blood, or bloody vomit, call your doctor immediately.Acetaminophen can cause severe skin reactions in rare cases. If you notice skin redness, a rash, or blisters that are peeling off and spreading, stop taking Excedrin Migraine immediately and contact your doctor.

Before you take this drug

Excedrin Migraine should not be given to children or teens with flu symptoms or chicken pox. Aspirin may cause Reye syndrome in children, which can be fatal.Excedrin Migraine should not be used if you have an allergy to acetaminophen or Tylenol (Tylenol), caffeine, aspirin (Aspirin), or NSAIDs such as Voltaren, Toradol (Toradol), Mobic (Relafen), Aleve (Orudis), Indocin (Lodine), Voltaren (Voltaren), Toradol (Toradol), Mobic (Relax Aspirin can cause fatal bleeding in the stomach or intestine. You may not be aware of these conditions if you take Excedrin Migraine.

If you suffer from any other medical conditions, such as:

  • Liver diseases; cirrhosis; a history of alcoholism; or If you consume more than three alcoholic drinks daily, your risk increases exponentially.
  • Seasonal allergy, or seasonal asthma?
  • Fever with a stiff neck
  • Stomach ulcer or stomach or intestinal bleeding ulcerative colitis
  • A bleeding disorder or blood clotting condition such as hemophilia
  • Kidney disease
  • If you take medicine to prevent or treat blood clots or to treat glaucoma,

If you are taking Excedrin Migraine for headache, you should seek medical attention immediately if:

  • A headache that is so severe you need to lay down
  • A headache that causes you to vomit
  • What feels like your worst headache ever?
  • A headache that is different from the usual headaches you get;
  • A headache every day
  • A headache may occur after bending or exercising, coughing, or after a head injury.
  • If you've never been diagnosed with migraines by a physician,
  • If you have your first headache after 50,

Aspirin can harm the heart of an unborn child, reduce birth weight, or cause other harmful effects. If you plan to get pregnant or are already pregnant, tell your doctor.Aspirin and caffeine may pass through breast milk, which can harm nursing babies. Excedrin Migraine should not be taken while breastfeeding.

Similar/related drugs

Nurtec ODT, Ubrelvy, Botox, diclofenac, Celecoxib, Sumatriptan, and Metoclopramide

How to take Excedrin Migraine?

Excedrin Migraine should be taken exactly as prescribed by your doctor or on the label. Excedrin Migraine should not be taken in excess. Overdosing on acetaminophen may cause liver damage or death.If you have an upset stomach, take the medicine with milk or food.Adult dosage: Take 2 caplets along with a glass of water. Ask your doctor if symptoms persist or worsen. Take no more than two caplets per 24 hours unless your doctor has instructed you to. Ask your doctor if you are under the age of 18.If your symptoms don't improve within 7 days of treatment or if you experience a fever that lasts more than 3 days or swelling or pain for longer than 10 consecutive days, call your doctor.When tested for glucose in urine, Excedrin Migraine may cause unexpected results. You should tell any doctor that treats you about your use of Excedrin Migraine.Tell the surgeon in advance if you will need surgery. It may be necessary to temporarily stop taking the medication.Store Excedrin Migraine away from moisture, heat, and light at room temperature.

What happens if I miss the dose?

You may not have a schedule for taking Excedrin Migraine, as it is taken only when necessary. If you have a regular schedule, take the missed dose as quickly as you can. If your next scheduled dosage is approaching, skip the missed dose. Should You Increase Doses of Medication After Missing One? (or)? No additional dose should be taken in order to make up for a missed one? (Or vice versa.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Acetaminophen overdose can result in liver damage or even fatality.Loss of appetite, nausea and vomiting, abdominal pain, sweating, or confusion are the first signs of an overdose of acetaminophen. Other symptoms include dark urine and yellowing skin or whites of the eyes.Other overdose symptoms include hallucinations (hallucinations), a fast or slow heartbeat, or seizures.

What should be avoided?

Alcohol can increase your risk of stomach bleeding while taking aspirin or liver damage when you take acetaminophen. Alcohol can increase the risk of stomach bleeding when taking aspirin or liver damage when taking acetaminophen.Before using any other medication for pain, menstrual symptoms, allergies, or fever, consult your doctor or pharmacist. Many combination medicines contain acetaminophen, also known as APAP. Combining certain products can result in an overdose of acetaminophen, which is fatal. Many combination medicines also contain caffeine and aspirin. You can check the label of a medication to see if it contains acetaminophen or caffeine.Avoid taking any other NSAIDs (nonsteroidal anti-inflammatory drugs) like aspirin (Advil), ibuprofen, naproxen, celecoxib (Aleve), diclofenac (indomethacin), meloxicam, and others.Excedrin Migraine should not be taken with coffee, tea, or energy drinks. These drinks can increase the effects of caffeine.

Interaction with other drug

Other drugs, such as vitamins and herbal remedies, may also interact with acetaminophen and caffeine. Inform your healthcare providers of all the medicines you are taking and those you plan to take.