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Ifosfamide

Generical name: Ifosfamide [eye-FOS-fah’mide] [ eye-FOS-fah-mide
Name of the brand: Ifex
Formulas for dosage: intravenous powder for injection (1 3 g; 1 g); Intravenous solution (50 mg/mL)
The class of drugs: Alkylating agents

What is Ifosfamide?

Ifosfamide is a component of other drugs used in the treatment of prostate cancer in men. Ifosfamide is generally prescribed when other treatments have been unsuccessful. Ifosfamide is also used for reasons not mentioned in this guideline.

Side effects of Ifosfamide

Contact emergency medical assistance when you are experiencing symptoms that indicate an allergic reaction (hives or breathing difficulties and swelling in your throat or face) or an extreme skin reaction (fever and burning eyes, sore throat, and skin irritation, as well as the skin being red or purple with peeling and blisters).

It is possible to contract infections more frequently, even deadly or life-threatening infections. Call your doctor immediately if you notice symptoms of an infection, like:

  • Fever, chills, and flu symptoms;
  • Oral and throat ulcers
  • Skin sores and blisters; pale skin; cold feet and hands;
  • Simple bleeding, unusual bruises;
  • Fast heart rate and slow breathing rapid heart rate, shallow breathing
  • Feeling lightheaded or sluggish.

Consult your physician immediately in the event that you suffer from any of these symptoms:

  • Unusual thoughts, confusion, or behaviors; hallucinations; seizures (convulsions);
  • Very little or no urination; hard or painful urination; you have bloody urine
  • Loss of bladder control
  • A seizure
  • Muscles you can't be in control of
  • Difficulties in your vision or hearing or ringing in your ears
  • Suddenly chest discomfort, wheezing, dry cough;
  • Dark urine, jaundice (yellowing of the eyes or skin), or
  • An injury that is not able to heal.

Common adverse effects of ifosfamide could nclude:

  • Vomiting
  • Vision problems, confusion, trouble thinking;
  • Numbness,
  • Tingling,
  • Burning pain;
  • Infections;
  • Urination issues
  • Hair loss.

This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Warnings

It is not recommended to take ifosfamide if you suffer from a medical condition that leads to urinary issues (such as an enlarged prostate).

Ifosfamide influences the immune system. It is possible to contract infections more often, including severe or fatal illnesses. Call your doctor if you are suffering from chills, fever, coughs, mouth sores, unusual bleeding, or bruises. Ifosfamide can impact the kidneys or the nerve body. Call your doctor immediately if you notice urinary problems or bleeding in the urine, issues in your vision or hearing, abnormal thoughts or behaviors such as hallucinations, or even a seizure.

Prior to use this drug

It is not recommended to treat ifosfamide if you are allergic to it or if you suffer from an illness that can cause urinary issues (such as an enlarged prostate).

Inform your doctor if you have ever suffered from:

  • Kidney disease;
  • Heart disease;
  • A bladder infection;
  • Treatment using busulfan;
  • The treatment for your bladder is radiation.

If you take ifosfamide, it can increase the risk of getting other types of cancer, like leukemia. Consult your physician about this possibility. Ifosfamide could cause birth defects if a pregnant woman is exposed to it during pregnancy.

Make use of effective contraception to avoid pregnancy, regardless of whether you're a male or female. Ifosfamide is used by both parents and can result in birth defects. Continue using birth control for a minimum of six months following treatment.

This medication could impact fertility (your capacity to have children), regardless of whether you're male or female. Women who are taking ifosfamide may have stopped having menstrual cycles or begun to show signs of early menopausal symptoms.

A woman who is receiving ifosfamide shouldn't breastfeed.

How to take Ifosfamide?

Your doctor will conduct urine and blood tests to ensure that there are no medical conditions that make it unsafe to use IFOSFamide. mIfosfamide is administered as an injection into the vein. Your healthcare provider will offer an injection. mIf this medication gets on your skin, clean it thoroughly with warm water and soap. Ifosfamide can be administered as an entire 21-day cycle of treatment; however, you'll receive the drug only for the first five days of each cycle. Your physician will decide how many cycles you'll receive.

Take plenty of fluids while you take ifosfamide.

Your blood must be tested frequently. Your kidney function, your heart and liver function, and your muscle and nerve function could also require a check. The timing of your cancer treatments could be delayed based on the results. Ifosfamide could have long-lasting effects on the body. You could also require health tests within a brief period of time following your last dose.

Details on dosage.

Usual Adult Dose for Testicular Cancer:

1.2 grams per square meter IV over at least 30 minutes per day for 5 consecutive days. repeat each 3 weeks or following the healing process from hematologic toxicity.

Comments:
To prevent the toxicity of bladder This medication is recommended to be administered in conjunction with full fluids (at least 2 liters of intravenous or oral fluids daily).
The following are the recommended dosages: Mesna is utilized to prevent the risk of hemorrhagic cystitis.

Use: To be used in conjunction with other antineoplastic agents to treat third-line testicular germ cell cancer.

What happens If I miss the dose?

Contact your doctor for advice. If you do not make an appointment to receive your injection with ifosfamide,

What happens If I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Avoid driving and other hazardous activities until you are aware of the effects of ifosfamide on your body. The way you react could be impaired.

Alcohol consumption can trigger the effects of ifosfamide that are associated with it, particularly nausea and vomiting. mGrapefruit could interact with ifosfamide, which can lead to unintentional negative side effects. Beware of using grapefruit-related products.

Don't receive the "live" vaccine while using ifosfamide, as you could get a serious infection. The live vaccines are measles, rubella, and mumps (MMR), as well as rotavirus, yellow fever, typhoid, varicella (chickenpox), zoster (shingles), and the nasal virus (influenza) vaccination. mnBeware of those with illnesses or suffering from infections. Inform your doctor immediately in the event that you show symptoms of an infection.

Interaction with other drugs

Utilizing ifosfamide in conjunction with other medications that make you sleepy or slow your breathing could cause serious adverse effects or even death. Ask your doctor prior to taking opioids, a sleeping pill, a muscle relaxer, or medication to treat an anxiety disorder as well as seizures.

There are times when it's not recommended to take certain medications together. Certain drugs may affect your blood levels and the other medications you are taking, which could cause more side effects or make the medication less effective. Numerous drugs can influence ifosfamide. This includes prescription as well as over-the-counter medicine, vitamins, and herbal remedies. The interactions between these products are not mentioned here. Inform your doctor of your current medications as well as any new medications you are about to start or stop taking.

 

 

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