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What is Idursulfase?
Idursulfase is a natural enzyme that some sufferers lack due to an inherited disorder. Idursulfase assists in replacing this deficient enzyme. Idursulfase is used to treat some of the symptoms of a genetic condition called Hunter's syndrome, also called mucopolysaccharidosis (MYOO-koe-pol-ee-SAK-a-rye-DOE-sis). Hunter syndrome is a metabolic disorder that occurs when the body does not have the enzyme necessary to break down certain natural substances. The substances can accumulate in the body, which can cause the growth of organs, a change in the structure of bones, changes to the facial appearance, breathing issues, heart issues, vision loss, as well as changes in physical or mental capabilities. Idursulfase could improve the walking abilities of people suffering from this condition. It is important to note that it isn't the cure for Hunter syndrome. Idursulfase can also be employed for reasons not mentioned in this medication guide.
Side effects of Idursulfase
A few side effects could be experienced during the infusion of idursulfase and within the 24 hours following. Seek medical attention immediately. If you experience symptoms warning signs of an allergic reaction that make you feel as if you're going to faint or hives, breathing difficulties, seizures (convulsions), and swelling of your lips, face, or tongue,
If you experience the reaction of an allergy to idursulfase, you'll be closely monitored following the second time you receive idursulfase.
Common negative side effects of idursulfase include:
- Vomiting,
- diarrhea;
- Headache;
- Muscles or
- Joint discomfort;
- Fever,
- cough;
- Itching, rash, or
- Flushing (warmth of redness, warmth, or tingly sensation).
This is not a comprehensive list of all the side effects. Others could happen. Consult your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.
Warnings
There are some side effects that can happen when you receive the idursulfase injection or for up to 24 hours following the infusion. Seek medical attention immediately. If you notice symptoms that indicate an allergy that make you feel like you're about to faint, such as hives, breathing difficulties, seizures (convulsions), or swelling of your lips, tongue, throat, or face,
How to take Idursulfase?
This medicine is for you if you're allergic to Idursulfase. Consult your physician if you suffer from asthma or other lung conditions. An allergic reaction can cause abrupt breathing issues. Your name could be included on a Hunter Outcome Survey while you use this drug. The aim of this survey is to monitor the development of this disorder as well as the impact that idursulfase exerts on long-term treatment.
It is unclear if idursulfase can harm an unborn baby. Consult your physician if you are pregnant or planning to become pregnant. It is not recommended to breastfeed your baby while you are taking this medication. Consult your physician about any possible risks.
What is the procedure for idursulfase?
Idursulfase is administered as an infusion into the vein. The healthcare provider will offer this injection every week. The medicine should be administered slowly, and infusions can take up to three hours or more to be completed. Your doctor might also recommend additional medications to help you avoid any allergic reactions to Idursulfase. All medications should be taken according to the directions. Your doctor should examine your health regularly.
Details on dosage:
Usual Adult Dose for Mucopolysaccharidosis Type II:
0.5 mg/kg once per week
Comment:
The clinical research didn't exclude patients who were older than 31 years, and, therefore, it's not clear how they will react to younger patients.
Use: For the treatment of Hunter syndrome (Mucopolysaccharidosis II [MPS II]).
Usual Pediatric Dose for Mucopolysaccharidosis Type II:
Ages 16 and over: 0.5 mg/kg intravenous once per week. Use: To treat Hunter syndrome (MPS II).
What happens if I miss the dose?
Consult your physician for treatment. If you do not make an appointment for the idursulfase treatment,
What happens if I overdose?
Because idursulfase can be administered by a health expert in a medical environment, an overdose is not likely to occur.
What should be avoided?
Follow your doctor's advice regarding any restrictions regarding drinks, food, or any activity.
Interaction with other drugs
Other medications can influence idursulfase. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about all the medications you currently use as well as any medications you are about to start or stop taking.