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Generatical name: epirubicin used for this drug. EP-i-ROO-bi-sin]

Drug class: Antibiotics or antineoplastics

What is Ellence?

Ellence is a treatment for cancer that blocks the spread and growth of cancerous cells within the body.Ellence is a treatment for breast cancer.Ellence is also used for reasons not mentioned in this guideline for medication.

Side effects of Ellence

See a doctor immediately. If you are experiencing symptoms of an allergic reaction, Ellence: hives, breathing difficulties, and swelling of your lips, face, and tongue.Epirubicin could cause serious adverse effects on your heart, which might not be reversible and may occur for months or years after receiving Ellence. Consult your doctor now if you notice signs of heart-related problems such as swelling, weight gain, rapid breathing problems, or shortness of breath.

Make sure to contact your doctor at the earliest opportunity if you are suffering from:

  • Rapid or slow heartbeats;
  • Simple bleeding, unusual bruising spots of red or purple under your skin
  • Unusual tiredness, feeling lightheaded or weak of breath; unusual fatigue; cold feet and hands;
  • Redness, pain, blisters, swelling, pain, or changes in the area where the injection was administered
  • Severe vomiting;
  • Symptoms of dehydration feeling very thirsty or hot, not being able to urinate, sweating heavily, or having hot or sweaty skin;
  • Fluid buildup within or around the lung and around the lungs. It can cause pain when you breathe and feel exhausted while lying down in bed, wheezing, gasping for breath, coughing up foamy mucus, cool and dry skin, anxiety, and rapid heartbeats.
  • Indications of a tumor cell's breakdown fatigue and weakness, muscle cramps, nausea, vomiting, diarrhea, a quick and moderate heartbeat, and tingling sensations on your feet and hands and around the mouth
  • Indicators of symptoms of fever, chills, flu, mouth sores, breathing shallowly, or light or blue-colored complexions

Common Ellence side effects can be:

  • Nausea, vomiting, diarrhea;
  • Temporary temporary loss of hair;
  • The appearance of ulcers or blisters in your mouth; swollen or red gums; difficulty swallowing;
  • Hot flashes, missed menstrual periods;
  • The skin, or your nails;
  • Fatigue, lack of energy
  • Red-colored urine for one or two days following the injection.

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088


It is not recommended to make use of Ellence in the case of an untreated, uncontrolled disease, liver disease that is severe, heart issues that are severe, or if you've recently suffered from a cardiac attack. It is possible that you will not be able to take Ellence in the event that you have been treated with a certain quantity of other cancer drugs. Inform your doctor that you are experiencing any burning, pain, or swelling while Ellence is injecting. Ellence could cause harmful effects on your heart. These could not be reversed and may occur for months or even years after receiving Ellence. Contact your physician right now if you notice signs of heart issues, including swelling, weight gain, rapid breathing problems, or shortness of breath. Ellence impacts our immune system. You are more susceptible to getting infections quickly, including deadly and fatal ones. You'll need regular medical examinations, and the treatment for cancer may be delayed.

Before you take this drug

Prior to receiving treatment with Ellence, inform your doctor about any other treatments and medications for cancer you've had, such as radiation. Ellence should not be taken if you are allergic to epirubicin or similar medications (daunorubicin, doxorubicin, idarubicin, mitoxantrone or valrubicin) or have conditions related to them such as:

  • Untreated or uncontrolled infection (including mouth ulcers);
  • Liver disease that is severe;
  • Severe heart conditions
  • If you've had an attack of the heart,

You might not be able to use Ellence in the event that you have been treated with a specific quantity of other cancer drugs.To ensure Ellence is suitable for you, ask your doctor if you've ever been:

  • Heart-related problems;
  • Radiation to the chest area;
  • Kidney or liver disease
  • The suppression of bone marrow;
  • Chemotherapy utilizing doxorubicin, daunorubicin, epirubicin, mitoxantrone, or idarubicin.

Utilizing Ellence could increase the risk of developing cancers that are not as common, for example, leukemia. Consult your physician about the possibility.

Both women and men who are taking this medication should utilize effective birth control methods to avoid the birth of a baby. Epirubicin can harm an unborn baby if either the father or mother is taking this drug.Epirubicin could cause women to stop experiencing menstrual cycles. It could also result in premature menopausal changes. Consult your physician if you are concerned about the potential risks.

How to take Ellence?

Ellence is administered via IV infusion into the vein. The healthcare professional will give you the injection.Your doctor will run blood tests to confirm that there are no issues that could make it unsafe for you to use Ellence.Contact your physician if you are experiencing any burning, pain, or swelling in the area around your IV needle during the time Ellence is injecting.If any of the medicine happens to get on your skin, cleanse it clean with soap and warm water.Epirubicin can affect the immune system. It is possible to contract infections more easily, including deadly or life-threatening infections. Your blood should be checked frequently. The heart's function could be monitored by using an electrocardiograph (sometimes known as the EKG). Your treatment for cancer could be delayed based on the outcomes of the tests.There may be additional medications to keep you from getting sick or treat certain adverse consequences. Use these medications as long as your physician prescribes them.

Details on dosage

Usual Adult Dose for Breast Cancer—Adjuvant:

Initial dosage: 100–120 mg/m2 IV over three to four-week cycles. Or, a total dose on day 1 of each cycle, or equally divided and administered on days 1 and 8 of every cycle.
The CEF-120 regime (repeat at least every 28 days over six cycles):
Cyclophosphamide 75 mg/m2 oral from Days 1 to 14
Epiubicin should be administered at 60 mg/m2 subcutaneously on Days 1-6 and 8-9 of treatment while Fluorouracil should be taken subcutaneously at 500 mg on each of those same dates.
A regimen of FEC 100 (repeat each 21-day period for six cycles):
Fluorouracil: 500 mg/m2 IV on Day 1.
-Epirubicin: 100 mg/m2 IV on Day 1
Cyclophosphamide: 500 mg/m2 IV on Day 1
Rates of infusion recommended:
For doses starting at 100–120 mg/m2, infuse the solution for 15–20 minutes.
For patients who require lower doses due to organ dysfunction or that require a change in dose throughout therapy, the duration of the infusion can be reduced proportionally, but it must not be shorter than 3 minutes in order to reduce the chance of thrombosis or perivenous extravasation. This can cause extreme cellulitis or vesication. necrosis of the tissue.
Direct push injections are not advised because of the potential for extravasation, which can occur even in the absence of sufficient blood return following needle aspiration. Venous sclerosis could result from injections into tiny vessels or multiple injections in the same vein.
Doses are suggested by the manufacturer. Check local protocol.
It is recommended to consider the use of antiemetics when they are used in combination with other emetogenic medications.
Patients who are prescribed the 120 mg/m2 regimen must be treated with prophylactic antimicrobials.
Use: As an adjuvant therapy in patients who show indications of axillary tumor involvement following the resection of breast cancer that is primary

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to receive an Ellence injection.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Epirubicin is a substance that can be absorbed into the body fluids (urine, feces, or vomit). At least for the first 48 hours following the time you received the dose, you should not allow the body fluids of your body to touch your hands or any other surfaces. Caregivers must wear rubber gloves when cleaning up a patient's fluids, handling trash that is contaminated or laundry, or changing diapers. Cleanse hands prior to and after taking off gloves. Cleanse linens and clothing that has been soiled separately from the rest of the laundry.

Interaction with other drug

Inform your doctor about all other medications, particularly:

  • Cimetidine (Tagamet);
  • Other cancer medications Other cancer medicines
  • Heart or blood pressure medications

This list isn't complete. Other medications can interact with epirubicin. These include medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs. are included here.