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SAM-e (same)

Generic name: s-adenosylmethionine (same) [S– a-DEE-noe-SIL-meth-EYE-oh-neen]
Names of brands: SAM-e, Natrol same
The class of drug: nutraceutical products

What is SAM-e (same)?

SAM-e (also called same) can be described as a manufactured version of a chemical that is naturally present within the body.same could be effective in alternative therapies as an aid to the treatment of osteoarthritis.same has been utilized in alternative medicine as an efficient treatment for itching, tiredness, and abnormal lab tests in people suffering from liver conditions and for improving the symptoms of people suffering from depressive disorders.

Other uses that aren't supported by research include treating alcohol-related liver diseases as well as schizophrenia, aging, Alzheimer disease, fibromyalgia, chronic back pain seizures, migraine headaches, premenstrual disorder, and chronic fatigue syndrome.

It is not known if same can be effective in treating any medical issue. The use of this product for medical purposes is not endorsed by the FDA. Same is not recommended as a substitute for medications recommended by your physician.

Same is typically sold as an herbal supplement. There are no controlled manufacturing standards for many herbal substances, and a few supplements that are sold on the market have been identified as having contamination with poisonous metals or other substances. Health supplements and herbal remedies should be bought from a trusted source to reduce the risk of contamination.same is also used for reasons not mentioned in this product's guide.

Side effects of SAM-e (same)

Contact a medical professional immediately. Get medical attention immediately if you show symptoms that indicate an allergy, such as asthma, difficulty breathing, or swelling of your lips, face, or tongue.

Get medical attention immediately when you exhibit signs associated with serotonin syndrome, for example, hallucinations, agitation, sweating or shivering, an increase in heart rate, muscle stiffness, or twitching. You may also experience loss of coordination, nausea, vomiting, or diarrhea.

While not all adverse consequences are fully understood, same is thought to be safe for a majority of adults if used according to the directions.

Common negative side effects of SAM include:

  • Hair color changes
  • Headache, dizziness;
  • Experiencing anxiety or fear;
  • Loss of appetite, vomiting, nausea, vomiting;
  • Dry mouth;
  • Diarrhea, constipation;
  • An increase in sweating increased sweating
  • Sleep problems (insomnia).

This isn't a complete list of all the side effects. Other side effects could be present. Contact your doctor for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Turmeric, Ginkgo Biloba


It is not recommended to use same if you suffer from bipolar depression, anxiety disorder, or are taking medication for depression.

Do not take same in the event that you've taken an MAO inhibitor within the last 14 days. A potentially hazardous interaction with a substance can occur. MAO inhibitors include isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, and tranylcypromine.

Prior to use this drug

It is not recommended to take SAM if you suffer from bipolar disorder (manic depression), anxiety disorder, or antidepressants.

Don't use same in the event that you've taken an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid linezolid Methylene blue injection rasagiline and phenelzine, as well as tranylcypromine and others.

Consult your doctor if you also take stimulant medicines, opioid medication, herbal products, or medications to treat mental illness, depression, Parkinson's disease, migraine headaches, severe infections, or for the prevention of vomiting and nausea. An interaction with same can cause a serious health condition known as serotonin syndrome.

Talk to a doctor, pharmacist, or any other healthcare professional to determine if it's appropriate for you to take this medication in the event that you suffer from:

  • A planned procedure;
  • Lesch-Nyhan syndrome;
  • Parkinson's disease.

It is unknown if SAM could harm an unborn baby. Do not use this product unless you have medical advice.

Same is deemed to be a risk to use in the case of nursing the baby. Do not take this product without medical advice if you're nursing a baby.Don't give herbal or health supplements to your child without medical recommendation.

How to take same?

If you are considering using same, consult advice from your doctor. You might also think about consulting someone who has received training in the use of herbal or health supplements.

If you decide to use same, take it as stated on the label or as recommended by your pharmacist, doctor, or any other healthcare professional. Don't use more of this product than what is suggested by the manufacturer on its label.same is best taken with a full stomach, at least 30 to 60 minutes prior to a meal or 2 hours after eating.

Consult your physician if symptoms don't improve or if they become worse.If you require surgery, then stop taking same at least two weeks in advance.Store it somewhere at room temp, clear from moisture and heat.

What happens if I miss the dose?

Don't miss the missed dose, and then take the next regularly scheduled dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any food restrictions, drinks, food, or any activity.

Interaction with other drugs

Do not use same in the absence of medical consultation if using any of these medicines:

  • Dextromethorphan (a cough medicine such as Robitussin, DM);
  • Serotonin-related drugs Serotonin-related drugs, for example, antidepressants, stimulants, or medications for migraines;
  • Levodopa;
  • A narcotic drug like meperidine (Demerol), pentazocine, and tramadol (Ultram, Ultracet).

This list isn't comprehensive. Other medications can affect same, which includes medications that are prescribed and available over the counter, vitamins, and herbal supplements. Some interactions with drugs are not listed here. Are listed here.