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DDAVP (nasal)

Generic name: desmopressin (nasal) [DEZ-mo-press-in]
Brand names: DDAVP nasal, DDAVP nasal nasal, Noctiva nasal, Stimate nasal
Drug class: antidiuretic hormones

What is DDAVP nasal?

DDAVP, a synthetic form of the hormone pituitary-derived, is produced by humans. The hormone regulates water use, blood pressure, and kidney function. DDAVP treats central cranial diabetes insipidus and increases thirst and urination due to head surgery or trauma. The Stimate medication is prescribed to people who have hemophilia A, or von Willebrand disease type I. Noctiva can be used for treating excessive nighttime urination among adults older than 50 years. Noctiva is not recommended for treating nighttime bedwetting. DDAVP can be used in other ways not mentioned in the medication guide.

Side effects of DDAVP nasal

If you experience any of the following signs and symptoms of an allergy reaction: difficulty breathing, hives or swelling on lips, face throat or tongue

DDAVP can cause severe side effects. If you experience:

  • Signs of low sodium: headache, confusion, hallucinations, muscle pain, weakness, or drowsiness. Also, nausea, feeling irritable or restless, and feeling drowsy
  • Rapid weight gain and swelling of the ankles or feet;
  • A seizure (convulsions);
  • Nasal problems: runny nose or sinus congestion.

Children and elderly adults are more susceptible to low sodium.

Some of the common side effects associated with DDAVP include:

  • Stuffy noses, runny or blocked noses, sinus problems, sneezing, and nosebleeds
  • Sore throat and cough
  • Dizziness;
  • Increased blood pressure
  • Nausea, stomach cramps;
  • Back pain, headaches, or both?
  • Flushing (warmth or redness)

There may be other side effects. Call your physician immediately if experiencing side effects; call the FDA's hotline, 1-800-FDA-1088, to report these.


Reduce your water intake and that of other liquids. Too much water may cause you to lose electrolytes and sodium. When certain medications are taken together, serious interactions may occur. You should tell your doctor if, in addition to the diuretic and steroid medications you are taking, If you experience any of the following symptoms of low sodium: headaches, weakness or muscle pain, nausea, loss of appetite, or drowsiness, call your doctor immediately.

Before you take this drug

If you have an allergy to DDAVP, then it is best not to use it.

You may be unable to use the DDAVP if:

  • A history of hyponatremia (low levels of sodium in the body);
  • Uncontrolled high blood pressure
  • Congestive heart failure;
  • Kidney disease ranging from mild to severe;
  • SIADH is a syndrome of excessive antidiuretic hormone production.
  • Fever, an infection, nausea, vomiting, or diarrhea, as well as any condition that can lead to excessive thirst, dehydration, or electrolyte imbalance.

DDAVP can have dangerous or unwanted effects. If you are also taking

  • A "loop diuretic" (water pill): bumetanide, ethycrynic acid, furosemide, or torsemide.
  • One option would be an oral, inhaled or injectable steroid medicine such as Budesonide, Dexamethasone, Fluticasone, Mometasone or Prednisone among many others.

DDAVP is less effective when you suffer from nasal and sinus issues (such as a deviated septum) or if there are any swellings or scarrings inside the nose.

If you suffer from:

  • Nasal problems, such as runny and stuffy noses;
  • A psychologic condition that results in extreme or abnormal thirst
  • An infection or illness accompanied by fever, diarrhea, and vomiting
  • congestive cardiac failure.
  • Kidney disease, or the inability to urinate,
  • A head injury or brain tumor;
  • cystic fibrosis

This medication has not been associated with harm to an unborn baby and should only be taken if you plan to become pregnant within 6 months of taking it. Please inform your healthcare provider as soon as you realize this may happen if planning pregnancy. DDAVP is not recommended to treat excessive urination that occurs as a result of normal pregnancy. You may be unable to breastfeed your baby while taking this medication. You should ask your doctor if there are any possible risks. Children should only take this medicine with prior consultation of a healthcare provider.

How to take DDAVP nasal?

DDAVP may be tested in urine by your doctor to ensure that it is right for you. Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Prime the nasal spray by spraying it four or five times into the air before your first use. The nasal spray should be primed again if it has been more than three days since you last used it. If you experience persistent vomiting, diarrhea, fever, or excessive sweating, call your doctor. This medicine can cause you to become easily dehydrated, leading to very low blood pressure and a severe electrolyte imbalance. Your doctor might need to perform frequent tests and adjust your dosage based on those results. You may be required to undergo blood or urine testing before resuming DDAVP use.

While using DDAVP, limit your water intake and fluids. Too much water may cause you to lose salt, which can lead to an electrolyte balance that is life-threatening. Children and elderly adults who use DDAVP should be especially careful about fluid intake. You should follow your doctor's advice about how much liquid you can drink. Keep the bottle at a temperature between 15 and 25 degrees Celsius, away from heat or moisture. Keep the bottle upright when not being used. Noctiva that has not been opened should be stored in the fridge. Keep the medication at room temperature after opening and use it within 60 days. Keep the DDAVP nasal tube refrigerated. Don't freeze. You can store the bottles closed at room temperature for up to three weeks if refrigeration isn't available.

Keep track of the number of sprays that you have used per bottle. Each bottle of Desmopressin Nasal contains a certain number of sprays. Even if the medicine is still inside, throw away the bottle once you have used the prescribed number of sprays. Pour it out into another bottle. Use this medication before the date of expiration printed on the bottle. You should seek medical help if DDAVP does not stop your bleeding.

What happens if I miss the dose?

If you are almost due for the next dose, skip the dose that was missed. Never take two doses of the same medicine at once.

What happens if I overdose?

Contact 1-800-222-1222 immediately if experiencing poison exposure symptoms like fatigue and rapid weight gain, which include drowsiness. Immediately seek medical assistance as overdose symptoms include dizziness or sudden weight gain.

What should be avoided?

Avoid drinking large amounts of fluids before bed.

Interaction with other drug

Inform your physician of any additional medications you are taking. DDAVP may have interactions with:

  • Any other nasal medication
  • Antidepressants are a type of medication.
  • Medications for bladder or urinary problems
  • Cold or allergy medication;
  • A diuretic, or "water pills."
  • Heart or blood pressure medications;
  • Medicine to treat mood disorders or bipolar disorder (or schizophrenia)
  • A steroid medication;
  • seizure medicine—carbamazepine, lamotrigine,
  • NSAIDs are non-steroidal anti-inflammatory medications. These include aspirin (Advil), ibuprofen, naproxen, Indomethacin (Meloxicam), diclofenac, and celecoxib.

The list below is not exhaustive. DDAVP may be affected by other drugs, such as prescription or over-the-counter medicines, vitamins, and herbs. This list does not include all drug interactions.



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