What are Hyaluronidase and immune globulin?
Hyaluronidase helps your body absorb other medications injected.It is a sterile solution made of human plasma. It contains antibodies that help protect your body against infections caused by various diseases.Adults with primary immune deficiency are treated by combining hyaluronidase with immune globulin.This medication guide does not list all possible uses for immune globulin and hyaluronidase.
Side effects of Hyaluronidase and immune globulin
If you experience any of the following symptoms of an allergic reaction, seek emergency medical attention: hives, wheezing or difficulty breathing, dizziness or feeling as if you may pass out, swelling of your lips, face, tongue, throat, etc.
Both hyaluronidase (as well as immune globulin) and hyaluronidase can cause serious side effects. If you experience:
- Signs of a brain blood clot: sudden numbness, weakness or slurred words (especially on one side), problems with vision and balance
- Signs of a blood clot in your heart or lungs: chest pain, rapid heartbeat, sudden hack, wheezing, and rapid breathing;
- Signs of a blood clot in the arm or leg include pain, swelling, warmth, and redness or discoloration.
- Signs of kidney problems: swelling, rapid weight gain, and no or little urination;
- Signs of a blood-cell disorder: pale or yellowed complexion, dark urine, feeling dizzy or lightheaded, rapid heartbeat, weakness, etc.
- Liver problems: rapid heart rate; dark urine; jaundice.
- Blue lips, blue or pale-colored fingers or toes, chest pain, or difficulty breathing are all symptoms of lung problems.
- Signs of a new infection include: high fever; flu symptoms; mouth sores; severe headache; neck stiffness; and increased sensitivity to light. Other signs are nausea and vomiting.
Side effects of immune globulin and hyaluronidase may include:
- The injection site may be swollen, red, itchy, or painful.
- Nausea, vomiting;
- Fever;
- Tired feeling
There may be other side effects.For medical advice regarding potential side effects, always contact your physician. For reporting side effects directly, the FDA can be reached at 1-800-FDA-1088.
Similar/related drugs
Hizentra, Octagam, Privigen, Gamunex-C, immune globulin intravenous, and Cuvitru
Warnings
If you have an IgA deficiency or antibodies to IgA, you should avoid using hyaluronidase.Immune globulins can cause blood clots. This is especially true if there are certain risk factors, such as cardiovascular disease or circulation problems. Contact your doctor immediately if you experience sudden numbness, weakness, difficulty speaking or seeing, chest pain, shortness of breath, or pain and swelling in your arm or legs.
Before you take this drug
This medicine should not be used if:
- Immune globulin A deficiency (iga), with antibodies to iga
Immune globulin may cause kidney damage or blood clots if you are at risk. Tell your doctor about any of the following to ensure that this medicine is right for you:
- Heart disease is characterized by problems with blood circulation or blood vessel disorders.
- A history of stroke or blood clots;
- Diabetes;
- Kidney disease
- If you are using estrogens (birth control pills) or hormone replacement therapy,
- If you are dehydrated,
- If you are 65 or older,
- If you are bedridden because of a severe illness,
- If you use a catheter,
FDA pregnancy class C There is no information on whether hyaluronidase or immune globulin can harm an unborn child. If you plan to get pregnant or are already pregnant, tell your doctor.This medicine is not known to pass into breast milk. It's also unknown if this medication could harm a baby who was nursing. You should tell your doctor if you're breastfeeding a child.The immune globulins are made from plasma, which is a part of the blood that may contain viruses or other infectious agents. Plasma donated is treated and tested to reduce the possibility of containing infectious agents. However, there is still some risk that it may transmit disease. Speak to your doctor about any risks or benefits associated with using this medication.
How to take Hyaluronidase and immune globulin?
Hyaluronidase and immune globulin are usually administered once every four weeks.Please read and comply with all instructions on your prescription label.To ensure you achieve the best possible results, your doctor may change your dosage from time to time. Take hyaluronidase or immune globulin only at the recommended dose. Do not exceed this amount or take it for a longer time.Infusion pumps are used to inject immune globulin and hyaluronidase under the skin. The medicine is injected into the body via a catheter that's placed either under your skin or in a vein. You will be shown how to inject medicine using an infusion pump by a healthcare provider. If you don't understand the instructions, do not inject yourself. For help, call your doctor, pharmacist, or nurse.Keep a journal if you are using this medicine at home. Record the dates, times, and location of the injection.The kit contains "dual vials" of hyaluronidase and immune globulin. The small vial is hyaluronidase, and the larger vial is immune globulin. These two medications should not be mixed. Inject hyaluronidase, then immune globulin in 10 minutes. Infusions should not contain any other medications.
Instructions for the patient are included in the hyaluronidase kit. These include instructions on how to prepare and inject your dose. Please follow the instructions carefully. If you have questions, ask your doctor or pharmacist.Shaking the vials can ruin the medication. Do not prepare your dose until you are ready for an injection. The medicine should be clear with no color. However, the immune globulin can appear pale yellow. If either medicine appears cloudy or contains particles, do not use it. For new medicines, call your pharmacist.Each vial or bottle of hyaluronidase (or immune globulin) is only for one single use. After one use, throw away the vial, even if some medicine is left.Only use disposable items (syringes, needles, catheters, tubing, etc.) once. Use syringes and needles in accordance with any local or state laws. Ask your pharmacist how to dispose of sharps in a container that is puncture-proof. This container should be kept out of the reach of pets and children.You may need to have frequent blood tests while using immune globulin and hyaluronidase.
It can produce unusual results in certain medical tests. Inform any doctor that you see about your use of hyaluronidase or immune globulin.Keep the original carton of the dual vial in the fridge. Protect from light and do not freeze.Allow the medicine to come to room temperature by taking a vial from the refrigerator 60 minutes prior to preparing your dosage. Once the vial reaches room temperature, it should not be returned to the fridge.Store the medicine at room temperature for up to three months. Store it away from moisture, heat and light sources.The medicine's expiration date is printed on the label.The medicine should not be heated before use.
What happens if I miss the dose?
If you forget a dose, call your physician immediately.
What happens if I overdose?
Call 1-800-222-1222 immediately if you suspect poisoning, or seek immediate medical advice.
What should be avoided?
Avoid injecting hyaluronidase or immune globulin into skin that's red, swollen, or otherwise abnormal. This could spread the infection.Avoid receiving a "live vaccine" while you are using hyaluronidase or immune globulin. The vaccine might not protect you as well and work less effectively during this period. Live vaccines are available for measles (chickenpox), rubella (MMR), yellow fever, typhoid (rotavirus), varicella, zoster, and influenza (nasal flu).
Interaction with other drug
Your kidneys can be damaged by immune globulin. This effect can be increased if you use other medications, such as antivirals (antiviral drugs), chemotherapy, injected bacteria, medicine for bowel problems, medicine to prevent rejection of organ transplants, injectable osteoporosis medicine, or some pain relievers and arthritis medicines.Other drugs, such as vitamins and herbal remedies, may also interact with hyaluronidase or immune globulin. Inform your healthcare providers of all the medicines you are taking and those you plan to take. This medication guide does not list all possible interactions.
