What is Fluticasone, umeclidinium, and vilanterol?
The combination of fluticasone and umeclidinium is used to reduce flare-ups and prevent airflow obstruction in adults with COPD, including bronchitis or emphysema. Adults can also be treated with fluticasone (umeclidinium), vilanterol, or both to control and prevent symptoms of asthma. Fluticasone, umeclidinium, and vilanterol are not to be used in the treatment of asthma or bronchospasm attacks. Vilanterol alone can increase the risk of death for asthmatics. This risk is reduced when vilanterol and fluticasone are used together in combination products. This medication guide does not list all possible uses for fluticasone, umeclidinium, and vilanterol.
Side effects of fluticasone, umeclidinium, and vilanterol
If you experience any of the following signs and symptoms of an allergic reaction: hives, difficulty breathing, swelling of lips, face, tongue or throat - please seek medical help immediately!
Side effects from fluticasone and umeclidinium can be serious. If you experience:
- Tremors, nervousness, chest pain, or fast or pounding heartbeats;
- Pain when swallowing; sores in the mouth or throat;
- If you experience wheezing or other breathing problems, discontinue use of this medication.
- Urination that is painful or difficult
- Blurred vision, red eyes, eye pain, or seeing halos around light
- A lung infection—fever and chills; a mucusy cough; a feeling of shortness of breath
- High blood sugar has many symptoms including increased thirst, increased urination and fruity breath odor.
- Low sodium level: leg cramps, constipation, irregular heartbeats, fluttering or tingling in the chest.
- Signs of hormonal disorders include fatigue or weakness, lightheadedness, nausea, and vomiting.
Fluticasone, umeclidinium, and vilanterol can cause the following side effects:
- Cold or flu symptoms include a runny nose or sinus pain, a sore throat or cough, and chest tightness.
- A lung infection;
- Nausea, vomiting, constipation, diarrhea;
- Urination problems
- Joint pain;
- Mouth sores, hoarse voice;
- Back pain and headaches
- Changes in taste and mouth pain
There may be other side effects. For medical advice regarding side effects, call your physician. For reporting side effects directly, the FDA can be reached at 1-800-FDA-1088.
Warnings
Only use fast-acting inhalation medicines for an asthma attack. If your breathing problems worsen quickly or you feel that your medication is not working, seek medical attention.
Before you take this drug
This medicine should not be used if you have an allergy to umeclidinium (fluticasone), vilanterol (vilanterolol), or milk proteins.
Inform your physician of any of the following issues:
- High blood
- A seizure;
- A weak immune system
- Any type of bacterial or fungal infection or infection caused by a parasite
- Liver disease
- Glaucoma or cataracts may also pose vision-related difficulties.
- Diabetes (or ketoacidosis);
- Osteoporosis;
- A thyroid disorder
- An enlarged prostrate or bladder obstruction can cause urination issues.
Do not abruptly stop taking an oral steroid medication.Follow your doctor's advice regarding dosage reduction. Inform your doctor immediately if you are pregnant or nursing. Under 18-year-olds should avoid using this medicine.
How to take Fluticasone, umeclidinium, and vilanterol?
Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. Follow the instructions on how to use your medicine. This medicine can be misused and cause serious heart side effects or death. Do not take the medication more than once every 24 hours. Please read and follow the instructions that come with your inhaler. If you don't understand the instructions, ask your doctor or pharmacist. Rinse your mouth with water after taking this medication to prevent a yeast infection.
Only use fast-acting inhalation medicines for an asthma attack. If your breathing problems worsen quickly or you feel that your medication is not working, seek medical attention. You may need to adjust your dose due to a change in health, stress, surgery, or COPD.Changes to dosage or schedule should only be made with approval from your healthcare provider. You may require frequent medical testing. You may need to have your vision and bone mineral density checked. Store away from heat, moisture, and light. Store the inhaler device inside the foil tray until you are ready to use it. Inhaler devices should be thrown away six weeks after they are removed from the foil pouch or when the dose indicator is zero.
Details on dosage
Adult dose for chronic obstructive pulmonary disease—Maintenance:
One inhalation (100 micrograms, 62.5 micrograms or 25 micrograms of Fluticasone/Umeclidinium/Vilanterol) should be administered orally once daily.
Maximum dose: 1 inhalation every 24 hours.
Comments:
It is not recommended to use higher doses or more frequent administrations.
Use with caution when switching from systemically active corticosteroid treatment.
After switching to this medication, patients who require oral or systemic corticosteroids must gradually wean themselves off systemic corticosteroids.
Uses:
Long-term maintenance treatment for patients with COPD, including chronic lung disease or emphysema
Reduce exacerbations in COPD patients who have a history of COPD exacerbations.
Adult dose for asthma maintenance:
One inhalation (100 micrograms, 62.5 micrograms or 25 micrograms of Fluticasone/Umeclidinium/Vilanterol) should be administered orally once daily.
Maximum dose: 1 inhalation (fluticasone, umeclidinium, or vilanterol 200 mcg-62.5 mcg-25 mcg) every 24 hours
Comments:
When choosing a starting dose, take into consideration the severity of your disease, any previous asthma treatment (including use of inhaled corticosteroids), how well you are controlling symptoms, and whether or not future exacerbations will occur.
Patients with an inadequate response to fluticasone, umeclidinium, or vilanterol 100 mcg-62.5 mcg-25 mcg may gain additional improvement with fluticasone, umeclidinium, or vilanterol 200 mcg-62.5 mcg-25 mcg.
Consider reevaluation and other therapies if the response to fluticasone, umeclidinium, or vilanterol 200 mcg, 62.5 mcg, and 25 mcg is inadequate.
If asthma symptoms occur between doses, inhale a short-acting beta-2 agonist. Albuterol is an immediate remedy for asthma symptoms.
What happens if I miss the dose?
If it is almost time for your next dose, forgo taking any missed pills. Never take two doses of the same medicine at once. Use no more than one inhalation per day.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention. The symptoms of an overdose include chest pains, a fast heartbeat, and feeling short of breath or shaky.
What should be avoided?
Avoid using a second inhaled medicine that contains vilanterol (such as formoterol, arformoterol, indacaterol, olodaterol, or salmeterol). Stay away from people who appear sick. This could spread their illness further and put yourself and other members of the household at risk. If you have been exposed to measles or chickenpox, call your doctor immediately for treatment. Fluticasone, a steroid, can cause serious side effects or even death in those who use it.
Interaction with other drug
Tell your doctor about your other medications, including:
- Atropine;
- Antifungal or antiviral medicines;
- Medicine to treat mental illnesses, such as depression, anxiety disorders, mood disorders, or depression;
- Cold or allergy medication (Benadryl and others);
- Medicine to treat Parkinson’s disease
- Medication to treat stomach issues, motion sickness or irritable bowel syndrome.
- Medicine to treat overactive urinary bladders
- Other bronchodilators
This list is incomplete. Fluticasone may be affected by other drugs, such as vitamins, herbal products, prescription medicines, and over-the-counter medicines. This list does not include all possible drug-drug interactions.
