What is Finerenone?
Finerenone is prescribed to adults suffering from a chronic kidney condition that is related to diabetes mellitus type 2. It is used to lower the risk of
- Kidney problems getting worse;
- A heart attack;
- Being hospitalized due to heart insufficiency;
- Death due to heart failure.
Finerenone can also be used for reasons not mentioned in this guideline.
Side effects of Finerenone
Contact a medical professional immediately. If you are experiencing warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, and tongue,
Finerenone could cause serious adverse side effects. Contact your physician immediately if you suffer from:
- High blood potassium -- nausea and weakness. It can also cause tingling sensations. chest discomfort, irregular heartbeats, lack of movement, or
- Low blood sodium: headache and confusion; issues with memory or thinking; weakness; unsteadiness.
Common negative side effects of finerenone can include:
- High potassium
- Low sodium
- Lower blood pressure.
This isn't an exhaustive list of all the side effects. Other side effects could occur. Seek medical advice if any adverse reactions arise; also report them immediately to FDA at 1-800-FDA-1088.
Warnings
Discuss with your doctor the other medications you take. Certain drugs shouldn't be taken with finerenone.
Before you take this drug
Finerenone is not a good choice if you have an allergy to it or have issues with the adrenal gland.
Certain drugs shouldn't be used in conjunction with finerenone. Your treatment plan could change when combined with:
- Nefazodone;
- An antibiotic—clarithromycin, telithromycin;
- Antifungal medicine: itraconazole, ketoconazole, posaconazole, and voriconazole;
- Antiviral medication to treat hiv or the hepatitis c--boceprevir cobicistat diesabuvir elvitegravir, indinavir, the combination of lopinavir/ritonavir, paritaprevir, ombitasvir and nelfinavir, siquinavir, telaprevir, and tipranavir
Inform your physician immediately if you were ever diagnosed with:
- Serious chronic liver illness;
- Potassium levels in the blood are high (hyperkalemia).
It is unknown whether finerenone can cause harm to a baby who is not yet born. Consult a physician if you are planning to become pregnant.It is not recommended to breastfeed while taking finerenone. It is recommended to do so at least for a day following the last dose.Not authorized for use by anyone less than 18 years of age.
How to take Finerenone?
Follow the directions on your prescription label and the medication guide or instructions sheets provided to you by your healthcare provider, who may adjust its dose as per their guidance. Take exactly as instructed!Finerenone is a medicine that can be taken in combination with food or not.If you are unable to take a tablet in its entirety, crush the tablet, then mix it with liquid or soft food like applesauce. Take the mixture in a rapid manner.You'll require medical tests.Keep it at room temperature, away from extremes of temperature or moisture.
Details on dosage
The usual adult dose for chronic kidney disease is:
Initial dose:
-To determine the estimated glomerular filter speed (eGFR) at a minimum of 60 mL/min/1.73 per m2 (20 mg taken orally, daily).
For eGFR 25-less than 60 mL/min/1.73 per m2, 10 mg orally at least once per day.
The recommended dose is 20 mg taken orally, once a day.
Comments:
The initiation of therapy is not recommended if serum potassium levels are higher than 5 mEq/L. If the levels of potassium in the serum exceed 4.8 or 5 mg/L, then the introduction of therapy could be considered with additional monitoring of serum potassium during the first four weeks based on clinical judgment and the levels of potassium in the blood.
Therapy is not advised for patients with an eGFR lower than 25 mL/min/1.73 meters2.
Use: To lower the chance of sustained eGFR decline and end-stage kidney disease, heart failure, nonfatal myocardial infarction, and hospitalization due to cardiac failure among patients suffering from chronic kidney Type 2 diabetes is oftentimes related to metabolic disease such as osteoarthritis or other joint ailments.
What happens if I miss the dose?
The missed dose should be taken on the same day that you remember it. The next dose should be taken at a regular time and according to your daily schedule. Don't take two doses at once.
What happens if I overdose?
For medical emergencies, seek immediate medical care or contact the Poison Help Line's toll-free number at 1-800-222-1222 for advice and help.
What should be avoided?
Don't consume potassium supplements or salt substitutes unless your doctor has advised you to. Grapefruit can react with finerenone, causing negative side effects. Avoid consuming grapefruit products.
Interaction with other drug
Certain drugs can interact with finerenone levels, and certain medications shouldn't be used simultaneously.Speak with your physician regarding any additional medications you are currently taking. This includes over-the-counter and prescription medications, vitamins, as well as herbal supplements. There are not all the interactions mentioned here.
