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Generic name: insulin degludec and liraglutide [IN-su-lin-de-GLOO-dek-and-LIR-a-GLOO-tide]
The class of drugs: antidiabetic combinations

What is Xultophy?

Xultophy is an infusion pen that contains an amalgamation consisting of insulin degludec and the drug liraglutide. Insulin degludec is a slow-acting insulin that begins to work within a few hours of injection and continues to work for a period of 24 hours.Liraglutide has a similarity to the hormone that is naturally produced in the body. It helps regulate insulin, blood sugar levels, and digestion.Xultophy is a medication used to reduce blood sugar levels in people suffering from diabetes mellitus. diabetic mellitus. The medicine is best used along with exercise and diet.Xultophy is generally prescribed in cases where your blood sugar levels haven't been controlled well by other medicines.Xultophy isn't suitable for those who suffer from type 1 diabetes.


It is not recommended to use Xultophy in the event that you suffer from multiple types of endocrine neoplasia (tumours within your glands) as well as the family or personal background of medullary thyroid cancer and insulin-dependent diabetes, or if you're experiencing an episode where the blood sugar levels are low or ketoacidosis in diabetics.In studies on animals, the liraglutide drug caused thyroid cancer or thyroid tumors. It isn't known if these effects will occur in people.Contact your doctor immediately. If you are experiencing symptoms of thyroid cancer like an increase in size or lump inside your neck, difficulty swallowing, a voice that is hoarse, or a shortness of breath,

Before you take this drug

It is not recommended to make use of Xultophy when you have an allergy to liraglutide or insulin. Avoid using this medication in the event of low blood sugar levels or if you suffer from:

  • Multiple endocrine neoplasia type 2 (tumours within those glands);
  • A family or personal background of medullary thyroid cancer (a kind of cancer that affects the thyroid);
  • Diabetic ketoacidosis (call your doctor to request advice on treatment);
  • An illness for which you take the drug liraglutide (Saxenda, Victoza) or an equivalent medicine such as liraglutide (albiglutide, dulaglutide, exenatide, and lixisenatide; Adlyxin; Byetta; Bydureon; Tanzeum; Trulicity).

To ensure that Xultophy is appropriate for you, ask your doctor if you previously had:

  • Pancreatitis;
  • The liver or kidneys are infected;
  • Stomach problems causing slow digestion;
  • Alcoholism;
  • Gallstones;
  • If you also take mealtime insulin,

In studies on animals, liraglutide was linked to thyroid tumours and thyroid cancer. It is unclear if the effects are present in those who are taking regular doses. Talk to your doctor about your risks.Consult your physician if you are breastfeeding or pregnant.Follow the advice of your doctor on how to use insulin when you are pregnant or get pregnant. Controlling diabetes is crucial during pregnancy, and having high blood sugar can cause problems for both the mother and the infant.Xultophy is not a product that has been approved to be used by anyone younger than 18 years of age.

Similar or related drugs

Ozempic, Mounjaro, metformin, Trulicity, Lantus, Victoza, and Levemir

What should I do with Xultophy?

Make sure you use Xultophy precisely as directed by your physician. Follow the instructions on the prescription label and go through all the medication guides or instructions sheets.Xultophy is injected into the skin. Usually, it is done each day during the same period. The healthcare professional will show you how to administer the medicine on your own. Make sure to use only the pen provided with this medication. Do not mix or dilute other medicines with Xultophy.You can use Xultophy either with or withoutYour doctor will show you the most appropriate areas of your body where you can inject this medication. You should use a different spot each time you administer an injection. Don't inject the same area twice in one row.

Don't inject Xultophy directly into skin that is tender, injured, swollen, pitted, thickened, or scaly, lumpy, or scarred.Contact your doctor if you suffer from persistent nausea and/or diarrhoea. You could easily get dehydrated after taking Xultophy, and this can cause the kidneys to fail.The blood sugar level of your body will have to be monitored regularly, and you might need additional blood tests in the doctor's office.There is a possibility that you may experience lower levels of blood sugar (hypoglycemia) and experience extreme hunger, dizziness, irritability, or anxiety. You may also feel shaky, nervous, or anxious. To cure hypoglycemia, consume or drink a rapid-acting sugar-rich food source (fruit juice crackers, hard candy raisins, or sugar-free soda).

Your physician may recommend a glucagon injection kit if you have severe hypoglycemia. It is important that your family or your closest friends know how to administer this injection in the event of an emergency.Be aware of indications of high glucose levels (hyperglycemia), like an increase in thirst or increased urination.The blood sugar levels may be affected by stress, illnesses, stress, surgery, alcohol consumption, or not eating meals. Talk to your physician before altering your dosage or medication schedule.Do not give away the Xultophy needle to anyone else, even if the needle is altered. Sharing these devices could allow the spread of disease or infection from one person to the next.Maintain Xultophy in the original container, protected from light and heat. Avoid freezing insulin or keeping it in the vicinity of the cooling element of the refrigerator. Get rid of any insulin that is stored in a freezer.

Storing without opening (not being used): Axultophy

  • Use and store in the refrigerator until the time of expiration
  • Keep it at room temperature for 21 days, and then use it within 3 days.

Storing open (in usage) Xultophy:

  • Place in a cool, dry place far from light and heat and utilise within 21 days
  • Place it in a fridge and make use of it for 21 days.

Do not keep the injection pen without an attached needle.Don't use the medication in the event that it appears like it's cloudy or has changed color. Contact your pharmacist to request the latest medication.

Details on dosage

Usual Adult Dose of Xultophy for Diabetes Type 2:

Basal Insulin or GLP-1 Receptor Agonist Naive:
Initial dosage 10 units of subcutaneously administered every day
Presently receiving basal insulin or GLP-1 receptor antagonist
Stop treatment with basal insulin or Liraglutide.
Initial dose: 16 units of subcutaneously every day
TITRATION: Adjust doses either up or down in intervals of up to 2 units each for 3–4 days, depending on the individual's metabolic requirements, blood glucose monitoring, and glycemic target, until the desired level of fasting plasma glucose is reached.
Maximum daily dosage Maximum daily dose: 50 units (insulin degludec 50 units) (liraglutide, 1.8 mg)Comments:
Dosing is given in insulin degludec units. The Liraglutide component dose for every amount of insulin can be seen on a table for dosing within the labelling on the package. Ten units of insulin provide 0.36 mg of Liraglutide.
To reduce the chance of hyperglycemia and hypoglycemia, further titration is possible by adjusting the amount of exercise, food intake, during acute illness, or in conjunction with other medications.
The mixture drug should not be suggested as a first-line treatment due to the uncertainties of the C-cell tumours found in rodents in humans.
The combination drug hasn't been examined in conjunction with prandial insulin.
Use: As an addition to exercise and diet, to increase glycemic control in adults suffering from type 2 diabetes mellitus.

Do I be concerned if I miss a dose?

Don't miss the dose you missed, and take the next dose at your regular time. Don't take two doses at once.If you fail to take the dose for more than 3 consecutive days consecutively contact your doctor to get instructions.

What will happen if I take excessively?

Get medical attention immediately or contact the Poison Help Line at 1-800-222-1222. You shouldn't take over 50 mg of this drug in a single day.

What should be avoided?

Do not consume alcohol. Check your other prescription labels to make sure that these medications don't contain alcohol.Avoid driving and other hazardous activities until you understand the effects of this medication on your body. Your reaction could be affected.

Side effects of Xultophy

Take immediate medical attention. If you are experiencing.

Symptoms that indicate an allergic reaction, Xultophy: hives, breathing difficulties, or swelling of your lips, face, or tongue.

See your doctor right away. If you are suffering from:

  • Severe nausea and vomiting;
  • Breathlessness (even even);
  • Swelling in your feet and ankles, weight gain rapid;
  • Symptoms of pancreatitis A severe pain in your upper stomach, spreading into the back of your body, sickness, as well as vomiting and a high heart rate;
  • Kidney issues The result is a lack of or very little urine, or painful or hard urination.
  • Low potassium levels leg cramps, constipation, irregular heartbeats, fluttering of your chest, a rise in thirst or urination, numbness, tenderness in muscles, or a sluggish feeling

Common Xultophy adverse effects include:

  • Nausea, diarrhoea;
  • Headache
  • Symptoms of the cold, like nasal congestion, running nose, and sneezing. The sore throat.

This isn't an exhaustive list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical adverse effects. It is possible to report any symptoms to the FDA by calling 1-800-FDA-1088.

Interaction with other drugs

Other medications can also affect the blood sugar levels of your body, and certain medications can enhance or reduce their effects. Xultophy. Certain medications can result in fewer symptoms of hypoglycemia. This can make it difficult to determine if your blood sugar levels are low. Inform all of your health professionals about any medications you are taking in the present and any medication you stop or start using. This includes over-the-counter and prescription medicine, vitamins, and herbs.