The Web Health



Generic name: alvimopan (pronounced AL-vi-MOE).

Drug class: opioid receptor antagonist

What is Entereg?

Entereg helps reduce the negative effects of opioids, which are used to ease pain after surgery. A few of the side effects associated with opioid medicines (stomach discomfort, bloating, and constipation) may delay the healing after surgery on the stomach or intestines.Entereg is not able to diminish the effects of pain-relieving opioids.Entereg can also assist in the restoration of normal digestive function following surgery to remove part of the intestinal tract.Entereg is only available under an exclusive program. You'll receive just 15 doses. You must sign up for the program and be aware of the dangers and advantages of taking alvimopan.

Side effects of Entereg

See a doctor immediately. If you experience any of the following symptoms, warning signs of allergic reactions include: hives, breathing difficulties, or swelling of your lips, face, and tongue.A few people experienced heart attacks after taking Entereg long-term. It's unclear if alvimopan is the real reason for the heart attack. Consult your doctor anytime if you are experiencing symptoms of a heart attack, such as:

  • Chest pain, pressure,
  • The pain may spread to your shoulder or jaw.
  • Anxiety, nausea, and sweating.

Common Entereg side effects may include indigestion.It is possible to suffer unpleasant stomach reactions if you take any opioid medication prior to the procedure.This isn't an exhaustive list of possible side effects, and other effects may also be present. Contact your doctor for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


It is not recommended to use Entereg in the case of severe kidney or liver disease or if you have been taking an opioid for more than seven consecutive days just prior to the procedure.A few people experienced heart attacks when taking Entereg for long-term use during clinical studies. It's not known if alvimopan is the primary reason behind the heart attacks. The medicine shouldn't be used for more than 7 days following your surgery.Contact your doctor immediately when you experience pale skin, no bleeding or bruises, painful or difficult urination, confusion due to an irregular pulse, leg pain and muscle weakness, an aching sensation, or increased frequency of urination.

Prior to using this drug

It is not recommended to take Entereg in the case of severe kidney or liver disease.Don't consume Entereg when you've taken opioids for more than seven days prior to the time of your intestinal surgery. Opioid medications include codeine, meperidine, fentanyl, hydrocodone, methadone, morphine, oxycodone, and many more.

To ensure that Entereg is appropriate for you, speak to your doctor if:

  • Kidney disease or liver failure;
  • Heart disease or a prior heart attack
  • Obstruction in the stomach (stomach or the bowels);
  • A colostomy or ileostomy;
  • A pancreas disorder;
  • If you've recently taken any opioid medications,

It isn't known if this medication could cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to be pregnant.It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

How do I take Entereg?

Entereg is only available in hospitals for a brief period of time.The initial dose of Entereg was given prior to the surgery. After that, you will be given two doses of Entereg every day for up to seven consecutive days.This medicine shouldn't be used for more than 7 days following the operation.

Info on dosage

Usual Adult Dose for Gastrointestinal Surgery:

Initial dose: 12 mg orally once for 30 minutes up to 5 hours prior to surgery.
Maintenance dosage: 12 mg taken orally twice a day, starting the day following surgery.
Maximum dose: Up to 15 doses
The duration of treatment is seven days, or until the time of discharge.
This medication is not recommended for patients who have consumed prescribed doses of opioids for longer than 7 consecutive days prior to the start of treatment.
Use: To speed up the process of lower and upper gastrointestinal healing after surgery, which includes part bowel resection and primary anastomosis.

What happens if I miss the dose?

As soon as possible, take your medication. However, avoid any missed doses if you are nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

Avoid this

Follow your doctor's advice regarding restrictions on drinks, food, or activities.

Interaction with other drug

Other medications may interact with alvimopan, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about the medicines you are currently taking as well as any medications you are about to start or stop taking.It is crucial to inform your physician if you've had an opioid prescription within the last 7 days. Opioid medicines are usually prescribed to treat severe to moderate pain. Some cough medications prescribed by doctors have opioids.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories