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Generic name: satralizumab [SAT-ra-LIZ-ue-mab]
Drug class: interleukin inhibitors

What is Enspryng?

Enspryng is a recombinant humanized monoclonal antibody that targets the human interleukin-6 (IL-6) receptors.Enspryng is a prescription medication for adults suffering from neurological myelitis optica spectrum disorders (NMOSD). NMOSD is an extremely rare and chronic autoimmune disorder that causes inflammation of the brain's central nervous system. This may lead to the destruction of the spinal cord, optic nerves, and/or the brain.It is only used when you have antibodies against the aquaporin-4 protein (AQP4). The doctor will test you for this antibody.

Side effects of Enspryng

Stop using this medication and seek emergency medical assistance. If you experience indications that indicate an allergy reaction, Enspryng. itching or feeling lightheaded; stomach discomfort, vomiting; difficulty breathing or swelling of your lips, face, tongue, throat, or face.You could contract infections more frequently, and even deadly or life-threatening infections. Call your doctor immediately if you notice symptoms of infection, such as:

  • Chills, fever, night sweats;
  • Sore throat. Persistent cough, feeling extremely exhausted;
  • Muscle pain;
  • Diarrhea, stomach cramps;
  • Loss of appetite appetite loss, weight gain;
  • More frequent urination and burning sensations when you urinate.
  • Swelling, redness, or tenderness.

Some common Enspryng-related side effects can include:

  • Headache, joint pain,
  • Nausea, stomach pain;
  • Fatigue;
  • The pain in your hands, arms, or legs;
  • It can be a rash
  • Signs of a cold, like nasal stuffiness or a runny nose sneezing, sore throat

This isn't a complete list of all the side effects. Others could happen. Consult with a doctor immediately if you are breastfeeding or expecting.


It can impact the immune system. You could contract infections more frequently, and even severe or fatal illnesses. Call your doctor for any symptoms of an infection (fever, fatigue, chills, cough, and muscle pain). diarrhea, stomach cramps, an increase in urination rate, burning after you urinate, skin sores, redness, swelling, or tenderness).Your doctor will determine whether you have an infection and treat it prior to starting or continuing with Enspryng.Your physician should check you for hepatitis and tuberculosis (TB) before you begin taking Enspryng.

Prior to using this drug

It is not recommended to use Enspryng if your body is allergic to satralizumab. Also, when you are suffering from an active infection, such as:

  • Hepatitis B,

To ensure Enspryng is safe for you, inform your physician if you've previously had tuberculosis, whether anyone in your family suffers from tuberculosis, or if you recently visited an area where tuberculosis can be found.

To be sure Enspryng is safe for you, inform your doctor if you ever suffered from:

  • An active or chronic illness;
  • Liver disorders, liver problems, liver problems, B (or if you're the carrier of hepatitis B), as well as
  • If you've recently had or are planning to get a vaccination,

Check to see if you're up to date on your vaccinations before you start treatments with Enspryng.It is recommended to avoid receiving a "live" vaccine for at least 4 weeks prior to taking Enspryng. The live vaccines are measles, rubella, mumps (MMR), and rotavirus. yellow fever, typhoid varicella (chickenpox), zoster (shingles), and respiratory flu (influenza) vaccines.You shouldn't receive a "non-live" (sometimes called inactivated) vaccine for at least two weeks prior to undergoing Enspryng. Non-live vaccines include the influenza (influenza) shot and injectable vaccines against hepatitis A or polio, as well as rabies.Consult with a doctor immediately if you are breastfeeding or expecting.If you are using Enspryng while pregnant, be sure that the doctor who is caring for your newborn baby knows that you were using this medication during your pregnancy. Being exposed to satralizumab during pregnancy can affect your baby's vaccination regimen.

How do I take Enspryng?

Utilize Enspryng precisely as directed by your physician. Follow the directions on your prescription label, and review all medication guides and instructions on the label.The doctor could conduct tests to ensure that you don't have any issues that could hinder you from using Enspryng.Enspryng is injected beneath the skin. The healthcare professional may instruct you on how to use the drug on your own.Be sure to read and adhere to any instructions for use that are included along with your medication. Consult your physician or pharmacist for clarification if you aren't sure about the instructions.Make an injection only when you are prepared to give it. Don't shake the already-filled syringe. Don't use it when the syringe has been damaged or the medicine appears cloudy, has changed color, or has particles inside it. Contact your pharmacist to request a new medication.Enspryng can be administered in three loading doses every two weeks, and then maintenance doses are given each week for four weeks. Your physician will determine the duration of treatment with this medication.Inject the entire medication into the syringe that has been prefilled. Contact your doctor if you aren't receiving the entire dose.

Your physician will tell you the best place on your body to inject Enspryng. Make sure to inject at a different location every time you administer an injection. Make sure you don't inject in the same spot twice in one row.You'll require regular medical tests.Consult your doctor if you notice any symptoms of an infection (fever, chills, fever, sore throat). Do not inject this medication in the event that you have symptoms of an infection.If you stop taking Enspryng after a short period, it is possible to start the medication again with loading doses every two weeks. Follow the instructions of your physician cautiously.Place it in the fridge. Be sure to keep it away from the light. Do not freeze.Remove the medicine from the refrigerator and allow it to get to room temperature for about 30 minutes prior to injecting your dose. Do not keep the medication in the refrigerator for more than eight days. Don't warm the medication, and keep it at an extreme temperature.Each syringe filled with prefilled medicine is intended only for use once. It is best to dispose of it after just one use, even if there's still some medicine in it.

Info on dosage

Usual Adult Dose for Neuromyelitis Optica:

120 mg subcutaneously in the weeks of 0 and 4, then 120 mg subcutaneously each 4 weeks.
Use: To treat neuromyelitis spectrum disorder (NMOSD) in patients of adult age with anti-aquaporin-4 (AQP4) antibody positivity.

What happens if I miss the dose?

Consult your physician for instructions in case you missed the dose.If you've been unable to take medication due to an adverse reaction or infection, be sure to follow the instructions of your physician regarding the procedure for restarting the medication.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

Avoid this

Avoid injecting this medication into moles, scars, broken skin, or skin that is painful, red, bruised, or hard.Don't receive any vaccines when using Enspryng.

Interaction with other drug

Other medications can be incompatible with natalizumab, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor your current medications as well as any medications you are about to start or stop taking.