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What is Eliglustat?
Eliglustat decreases the production of a specific protein within the body of patients suffering from Type 1 Gaucher disease.Gaucher's disease is an inherited disorder that results in the body not having the enzyme that is needed to break down certain fatty substances (lipids). Lipids are able to accumulate in the body, leading to symptoms like easy bleeding or bruising, weakness, anemia, bone or joint discomfort, and swelling of the liver, spleen, or weak bones that can easily break.Eliglustat is used for treating mild to moderate Gaucher's disease in adults. Eliglustat is prescribed only when the specific liver enzyme (2D6) within your body degrades or converts drugs in a specific amount.Eliglustat can improve the health of the spleen, liver, bones, and blood cells in people suffering from Type I Gaucher disease. But it's not an effective treatment for this condition.Eliglustat can be prescribed for other purposes that aren't listed in this guide.
Side effects of Eliglustat
Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue,Eliglustat may cause serious side effects. Contact your doctor immediately in the event that you experience:
- Suddenly dizzy (like the possibility of passing out) or
- Heartbeats that are fast and pounding; the heartbeats of your chest are fluttering.
Common negative effects of eliglustat could include:
- The symptoms of diarrhea, nausea, and stomach pain
- Headache;
- Tiredness;
- Back pain
- The pain in your arms and legs.
This list does not represent a comprehensive listing of all possible side effects. Other side effects could occur. Consult your physician to seek medical advice on adverse effects. Report adverse reactions directly to the FDA at 1-800-FDA-1088.
Similar/related drugs
Cerezyme, Cerdelga, and miglustat
Warnings
It is not recommended to use eliglustat when you suffer from severe kidney or liver disease.Eliglustat can trigger serious heart problems, particularly if you take various other medications in conjunction with it. Do not fail to inform your doctor of all medications you take.
Before you take this drug
Sometimes, it's not recommended to take specific medications in conjunction. Some drugs can cause a rise or decrease in the level of blood cholesterol, which can cause adverse consequences or render the drug less efficient. Eliglustat may also alter the blood levels of some other medications, which can make them less effective or worsen their negative effects.
Your doctor might need to modify your treatment when you take one of the following medications:
- John's wort;
- Antifungal medicine;
- Tuberculosis medicine;
- Seizure medicine;
- Blood pressure medication or heart
- An antidepressant
- Medication to treat mental illness.
It is not recommended to use eliglustat in case you have an allergy to the product or suffer from any of the following:
- Extremely severe liver illness that causes severe liver
Have you experienced:
- Long QT syndrome or another heart rhythm disorder
- The heart or an heart attack;
- Liver disease liver disease
- Kidney disease.
It isn't known if eliglustat could cause harm to a baby who is not yet born. Consult your physician if you are pregnant or planning to be pregnant.It is not recommended to breastfeed during the course of this medication.Eliglustat is not recommended for use by any person less than 18 years old.
How to take Eliglustat?
The doctor will conduct an aa genotype blood test to ensure that it is the best procedure for you.Follow the instructions on the prescription label and go through all medication guides or instructions sheets. The doctor might alter the dosage.Be certain to take your medication exactly as prescribed.If you have switched to eliglustat from a medication that replaces enzymes, wait at least 24 hours after the last dose of the other medication before beginning to take eliglustat.Eliglustat is typically taken one or two times a day, depending on how your genotype tests are performed. Follow the instructions of your doctor for dosage with care.Drink this medicine by drinking a cup of fluid.Use the medicine every day, whether with or without eating.Suck the capsule whole, and don't crush, chew, break, or even open it.Eliglustat may cause serious heart issues. Your heart function could be assessed using an electrocardiograph, also known as an ECG (sometimes referred to as an EKG), prior to taking this medication.Keep it at room temperature, without heat or moisture, to extend its shelf life.
Details on dosage
Usual Adult Dose for Gaucher Disease:
Dose suggestions are given in accordance with CYP450 2D6 Metabolizer status.
Extensive metabolizers (EM); intermediate metabolizers (IM); poor metabolizers (PM)
The EM dose is 84 milligrams taken orally twice daily.
IM Dosage: 84 mg orally, twice daily.
PM: 84 mg taken orally, every day, once
Dose Reduction: 84 mg taken orally every day. Recommended for:
-EM or IM using an active or moderate CYP450 2D6 inhibitor
-EM using a strong or mild CYP450 3A inhibitor
-EM with a mild impairment to the liver using a weak CYP450 2D6 inhibitor
EM with a mild impairment to the liver using a strong, moderate, or moderately weak CYP450 3A inhibitor
Comments:
CYP450 2D6 ultra-rapid metabolism (URM) might not be able to achieve the required drug concentrations for therapeutic impact.
Dose advice cannot be given to patients whose genotype is not able to be identified (indeterminate metabolisms).
Use: To provide long-term care for patients with Gaucher type 1 disease with CYP4502D6 intensive metabolism, intermediate metabolizers, or poor metabolizers as identified by an FD-approved test.
What happens if I miss the dose?
You should take the medication as quickly as you are able, but do not take your missed dosage if it's nearing the time to take the next dose. Don't have two doses at one time.Refill your prescription prior to the time that you are out of medication completely.
What happens if I overdose?
For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.
What should be avoided?
Grapefruit can interact with eligligat and cause adverse reactions. Do not use grapefruit-related products.
Interaction with other drug
Eliglustat could cause serious heart conditions. The risk is more likely if you take certain other drugs to treat asthma, infections, and heart conditions such as high blood pressure, depression, mental illness, malaria, cancer, or HIV.A variety of drugs can affect the elicitation process, and certain drugs are not recommended to be taken simultaneously. Discuss with your doctor your current medications as well as any medication you take or stop taking. This includes prescription and over-the-counter medicine, vitamins, and herbal supplements. The interactions between these products are not mentioned here.