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The name of the generic is eflapegrastim [EF-la-PEG”

The brand name is Rolvenden.
Dosage form: subcutaneous solution (xnst 13.2 mg/0.6 mL)
Drug class: colony-stimulating factors

What is Eflapegrastim?

Eflapegrastim is a drug used by adult patients to manage neutropenia or a lack of white blood cells in certain cases due to cancer, chemotherapy, or other ailments.Filgrastim is a treatment for people of all ages to combat neutropenia. the absence of white blood cells in certain cases due to tumors, bone marrow transplants, chemotherapy, or other medical conditions.Eflapegrastim could also be used to treat conditions that are not mentioned in this guide.

Side effects of Eflapegrastim

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, and swelling of your lips, face, and tongue.Flap Grastim could cause the spleen of your body to expand and could cause it to break (tear).Call your doctor immediately if you notice a sudden or intense discomfort in your stomach's left side that is spreading onto your shoulders.Capillary leaks are a rare but serious consequence. Contact your physician immediately when you notice signs of this condition, such as nasal congestion or a runny nose, followed by fatigue, thirst, reduced urination, difficulty breathing, and sudden swelling or weight gain.Filgrastim may cause serious side effects. Consult your physician right away in the event that you experience:

  • Breathlessness and rapid breathing
  • Trouble breathing or pain in the chest
  • Simple bleeding or unusual red or purple spots on your skin
  • Tiredness, abdominal pain, back pain;
  • Symptoms or signs of symptoms of infection symptoms of infection: fever chills, the sore throat or body aches, unusual fatigue, lack of appetite,
  • Kidney issues: no or little urination of the urine, blood in your stools or in your ankles, face, or around your ankles.

Common negative side effects of filgrastim include:

  • Nausea, diarrhea;
  • Muscles, bone, or joint discomfort;
  • Back discomfort;
  • Headache;
  • Tiredness;
  • Rash;
  • Fever
  • The skin is pale, and it feels lightheaded or breathless, with cold hands and feet.

This is not a comprehensive list of possible side effects, and other side effects could be present. Consult a physician if experiencing adverse effects. Any adverse reactions should also be reported directly to the FDA at 1-800-FDA-1088.


Eflapegrastim could cause your spleen to grow larger and may cause it to break (tear). Contact your doctor immediately when you experience an acute or sudden discomfort in your stomach's left side that is spreading into your shoulders.

Before you take this drug

Do not take filgrastim in case you have an allergy to eflapegrastim, filgrastim, or pegfilgrastim.

Speak to your doctor if you were ever diagnosed with:

  • Sickle cell disorder;
  • Kidney disease.

Consult a physician if you are breastfeeding or pregnant.

How to take Eflapegrastim?

Follow all instructions on your prescription label, and go through all medication guides or instructions sheets.Make sure you use the medication exactly as prescribed.Eflapegrastim is injected beneath the skin of a medical doctor.You will receive one dose of filgrastim per course of chemotherapy. It is not recommended to take this medication for more than 14 days prior to or within 24 hours of your chemotherapy dosage.You'll need to take regular medical tests.

Details on dosage

The Usual Adult Dose of Neutropenia with Chemotherapy

Usual dosage: 13.2 mg subcutaneously once during a chemotherapy cycle.
Doses should be given at least 24 hours following cytotoxic chemotherapy.
The drug should not be administered in the 14-day period between 24 and 48 hours following the administration of the cytotoxic chemotherapy.
This drug is not recommended for mobilization of peripheral blood progenitor cells for transplantation of hematopoietic stem cells.
Use: To lower the risk of infection that manifests itself as the presence of febrile neutropenia for patients suffering from non-myeloid malignancies treated with myelosuppressive anticancer drugs that are associated with a significant rate of neutropenia and fever.

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to receive your injection of eflapegrastim.

What happens if I overdose?

In case of medical emergencies, seek immediate medical assistance or contact the Poison Help Line at 1-800-222-1222.

What should be avoided?

Beware of those who are sick or suffer from infections. Inform your doctor immediately when you begin to show symptoms of an infection.

Interaction with other drug

Other drugs can interact with eflapegrastim's effects, such as prescription and non-prescription medications, vitamins, and herbal products. Discuss with your doctor all the other medications you are taking.



Prescription only

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