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Generic name: oxymetazoline ophthalmic [OX-i-me-TAZ-oh-leen-off-THAL-mik]
The brand names are: Upneeq, Visine Long-Lasting

What is Upneeq?

The Upneeq (for eyelids) is used to relieve temporary discomfort from mild irritation to the eyes or irritation caused by minor irritations.

Upneeq is a prescription form of oxymetazoline, an eye drop that is utilized to address the condition known as blepharoptosis, which results in the appearance of an unnaturally droopy eyelid over both or one of the eyes. Upneeq is a prescription drug for adult patients and children who are 13 years old.The drug can also be used to treat conditions not mentioned in this medication guide.

Side effects of Upneeq

Contact a medical professional immediately. If you are experiencing warning signs of an allergic response, such as hives, difficulty breathing, and swelling of your lips, face, and tongue,

Upneeq can cause serious adverse reactions. Stop using the product and contact your physician immediately in the event that you experience:

  • Feeling faint, as though about to collapse.
  • Eye redness that is persistent or getting worse;
  • Eye discomfort eye pain
  • Changes within your eyes.

Common adverse effects of Upneeq could include:

  • Slight burning or stinging in the eye;
  • Watery or blurry eyes
  • Mild headache, dizziness, and nervousness.

This list does not constitute an exhaustive listing of potential side effects; other adverse reactions may occur and should be discussed with your physician for advice regarding medical adverse reactions or reported to FDA at 1-800-FDA-1088.

Similar/related drugs

Oxymetazoline ophthalmic


Follow the instructions on your prescription label and on the label of your package. Be sure to inform your healthcare professionals about your medical ailments and allergies, as well as the medicines you are taking.

Prior to use this drug

You shouldn't make use of Upneeq if you are sensitive to it.

Inform your physician immediately if you have ever experienced:

If you are suffering from one of the above conditions, you should consult your doctor or pharmacist prior to using the prescription (over-the-counter) form of oxymetazoline.

Talk to your doctor before taking Upneeq if you are nursing or pregnant.

Follow the instructions on the medication label regarding the dosage for children. Don't give this medicine to a child who is younger than six years old without a medical recommendation.

How to take Upneeq?

Take exactly as indicated on the label or as directed by your physician. If you take this medication excessively or frequently, it can cause a worsening of your symptoms and damage the blood vessels that line your eyes.

Avoid wearing contact lenses made of soft materials. The preservative contained in this medication can permanently stain your lenses. Make sure to take the medicine for at least 15 minutes prior to inserting your contact lenses.Before using eye drops, always ensure your hands are thoroughly cleansed.Make sure to shake the eye drops thoroughly prior to each use.

To apply the drops to your eyes, tilt your head back to the side and pull back the lower eyelid, creating tiny pockets. Then, hold the dropper in front of the eye, and then squeeze the drop into the pocket. Close your eyes for at least 1-2 minutes to relax your eyes and maintain focus.Only use the number of drops that are recommended.Don't touch the tip of your eyedropper or put it directly in your eyes. A dropper that is contaminated could affect your eyes and cause serious vision problems.

Consult your doctor if symptoms don't improve after three weeks of therapy.Keep this medicine in a straight position at room temperature. Avoid freezing.Make sure this medicine is kept out of the reach of young children. Certain eye medications can trigger serious medical issues in an infant who swallows or sucks the drops of eye medication.

Each container for single-use is intended for one purpose only. It is discarded after just one use, regardless of whether there's still some medicine in it.

What happens if I miss the dose?

Because Upneeq is often used for emergencies, you might not be on a dose schedule. Do not miss any doses in the event that it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

The overdose of Upneeq should not pose a danger. Get medical attention immediately or contact the Poison Help Line at 1-800-222-1222 if you have accidentally swallowed the medication.

What should be avoided?

Do not take any other eye medications unless your physician advises you to.

Interaction with other drugs

Consult a physician or pharmacist prior to using oxymetazoline in conjunction with other medications, particularly:

  • Heart or blood pressure medication;
  • Beta blockers: carvedilol, atenolol, labetalol, and metoprolol; propranolol, nadolol, or sotalol, as well as
  • MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine and others.

This list isn't complete. Other medications may interact with oxymetazoline, which includes prescription and over-the-counter medicines, vitamins, and herbal products. There are many possible interactions between drugs that are included here.