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Efinaconazole Topical

Generic name: efinaconazole topical [EF-in-a-KON-a-zole-TOP-ik-al]

Brand name: Jublia

Dosage form: topical solution (10%)
Drug class: topical antifungals

What is Efinaconazole Topical?

Efinaconazole topical medication is prescribed to treat onychomycosis, a fungal infection of the toenail. Efinaconazole topical may also be used for purposes not listed here, so please speak with your healthcare provider prior to beginning therapy with any new medication.

Side effects of Efinaconazole Topical

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, face, or tongue.

Efinaconazole topical can cause serious adverse side effects. Consult your physician right away. If you suffer from:

  • Extreme irritation, itching, or swelling of the affected nail.

Common adverse effects of efinaconazole topical can be:

  • Redness, pain burning, stinging burning, or blisters in the area the medicine was applied or
  • Ingrown toenail.

This is not a comprehensive list of possible side effects, and other side effects could be present. Consult your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


Follow the directions on your prescription label and the package. Be sure to inform your healthcare professionals about your medical issues, allergies, and any medications you take.

Similar or related drugs

terbinafine, itraconazole, Lamisil, griseofulvin, topical ciclopirox, and Jublia

Before you take this drug

Consult with your physician if you are breastfeeding or pregnant.Efinaconazole topical isn't recommended for use by anyone less than six years old.

How to take Efinaconazole Topical?

Follow the directions on the prescription label and review all medication guides and instructions sheets. Make sure you use the medicine precisely as prescribed.Efinaconazole topical cream is typically applied every day over up to 48 months (approximately 1 year).Be sure to read and adhere to any instructions that are included along with your medication. Talk to your pharmacist or doctor for clarification if you are unsure of the instructions.Consult your physician if symptoms don't improve or if they become worse after using efinaconazole topical.Make sure you use efinaconazole for the full duration of treatment, even if symptoms improve quickly. The absence of doses may increase the chance of developing an infection that is resistant to medications.

After you have applied efinaconazole topically for 10 minutes, you should wait for at least 10 minutes before taking a shower or bath.Place the bottle upright at room temperature and away from heat and moisture. Make sure the bottle is tightly sealed when not being used. Do not freeze the bottle.Topical efinaconazole is flammable. Avoid using near-high temperatures or in open flames. Don't smoke until the gel has completely dried off your nails.

Details on dosage

Usual Adult Dose for Onychomycosis—Toenail:

Apply this treatment to the affected toenail(s) every day for up to 48 weeks.
The flow-through applicator with integrated flow-through is recommended for use.
The toenail, folds of the toenail, and folds of the toenail bed hyponychium, as well as the surface of the toenail plate, must be fully covered.
Use: To treat the treatment of onychomycosis in the toenail(s) caused by Trichophyton rubrum or T mentagrophytes.

Usual Pediatric Dose for Onychomycosis—Toenail:

6-year-olds and older 6 years or older: Apply the cream to the affected nail(s) daily for up to 48 weeks.
The integrated flow-through brush applicator is recommended for use.
The toenail, folds of the toenail, the toenail bed, hyponychium, and the underneath of the plate must be fully covered.
Use: To treat the treatment of onychomycosis that affects the toenail(s) caused by T rubrum and T mentagrophytes.

What happens if I miss the dose?

Utilize the medication as soon as you are able, but do not miss your missed dosage if you are nearing the time to take the next dose. Don't take two doses in one go.

What happens if I overdose?

A dose of efinaconazole that is too high isn't expected to be a danger. Get medical attention immediately, or contact the poison help line toll-free at 1-800-222-1222 if you have accidentally swallowed the drug.

What should be avoided?

Do not put efinaconazole on your skin, in your mouth, eyes, or vagina. Efinaconazole topical can be used only on your toenails.Do not get a manicure or apply nail polish to your toenails.

Interaction with other drugs

Nail care is unlikely to be affected by any other medications you take. However, many drugs interact with each other. Inform your health care providers about the medications you are taking, which include medications that are prescribed and available over the counter, vitamins, and herbal remedies.