What is Doxylamine and pyridoxine?
Doxylamine reduces the effects caused by the natural chemical histamine. Pyridoxine is a B6 vitamin. The combination of doxylamine and pyridoxine can be used to treat nausea during pregnancy.Morning sickness, also referred to as morning delirium. This medication guide does not list all possible uses for doxylamine or pyridoxine.
Side effects of Doxylamine and pyridoxine
If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.
Some of the common side effects associated with doxylamine or pyridoxine include:
- Drowsiness.
There may be other side effects. Call your physician if experiencing side effects; for reporting side effects to the FDA call: 1-800-FDA-1088
Warnings
Use doxylamine or pyridoxine only if you've taken an MAO inhibitor in the last 14 days. Examples include isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), tranylcypromine, and methylene blue.
Similar/related drugs
Ondansetron, Lorazepam, Meclizine, Zofran, Promethazine, and Diclegis
Before you take this drug
If you've taken an MAO inhibitor within the last 14 days, do not take pyridoxine and doxylamine. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), methylene blue injection, tranylcypromine, and others. This medicine should not be used if you have an allergy to doxylamine, pyridoxine, or other antihistamines like Benadryl and Dramamine.
Tell your doctor about any of the following:
- Asthma or other breathing disorders;
- Glaucoma is an increase in pressure in your eye.
- Blockage of the digestive tract (stomach, intestines);
- A stomach ulcer
- Other urination issues or bladder obstruction.
Breast-feeding is not recommended while taking doxylamine or pyridoxine. Anyone younger than 18 is not allowed to use doxylamine or pyridoxine.
How to take Doxylamine and pyridoxine?
Read and follow any instructions or guides provided with your medication, such as following its label directions. Take doxylamine and pyridoxine together with a glass of water on an empty stomach. Take pyridoxine and doxylamine either at night or in the morning. Please follow your doctor's instructions for dosage. Do not chew or crush the capsule. If your symptoms don't improve or worsen, seek medical assistance immediately. Severe vomiting or persistent dehydration can lead to serious medical issues. You may get false results if you use this medicine. Tell the lab staff that you are taking pyridoxine and doxylamine. Store away from heat and moisture at room temperature. Keep the original packaging of the pills and the packet or canister containing the moisture-absorbing preservative.
Details on dosage
Adult dose for nausea or vomiting:
Doxylamine-pyridoxine delayed-release tablets, 10 mg:
Initial dose: orally, 2 tablets at bedtime.
Maintenance dosage: 2 tablets, orally, once or twice a week to 4 tablets, orally, three times a week.
Maximum dose: 4 tablets per day.
Doxylamine-pyridoxine extended-release tablets (20 mg/40 mg)
Initial dose: Take 1 tablet at bedtime orally.
Maximum dose: 2 tablets per day.
Comments:
The treatment should only be administered as directed and not on a need-to-know basis.
Patients should be reassessed regularly to determine if they still need treatment.
Use: Treatment for nausea and vomiting during pregnancy when conservative treatment does not work.
What happens if I miss the dose?
If it is almost time for your next dose, skip any missed ones and do not double up on any medications at the same time. Doing so could increase risk and possibly harm you in other ways. Take no more than two tablets or capsules per 24 hours.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention. Overdose symptoms include dry mouth, extreme dizziness or drowsiness, confusion, restless feelings, dilated pupils, rapid heartbeats (convulsions), muscle pain, or weakness, along with a fever and dark-colored urine.
What should be avoided?
Do not drive or engage in hazardous activities until you have a better understanding of how doxylamine pyridoxine affects you. You could have impaired reactions. Avoid alcohol. Alcohol can make you drowsy due to doxylamine or pyridoxine. While pregnant, you should only take medicine on your doctor's recommendation.
Interaction with other drug
This effect can be worsened by combining doxylamine with pyridoxine or other drugs that cause drowsiness. Before taking an opioid, sleeping pill, muscle relaxer, or medicine to treat anxiety, depression, or seizures, consult your doctor. Other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal supplements, may also affect pyridoxine and doxylamine. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.
