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Generic name: doxylamine and pyridoxine [dox-IL-a-meen-and-PIR-i-DOX-een]
Classification of drugs: Miscellaneous antiemetics

What is Diclegis?

Diclegis is a delayed-release tablet that contains a combination of doxylamine and pyridoxine. Doxylamine can be described as an antihistamine that decreases the effects of the natural chemical histamine within the body. Pyridoxine is an ingredient that contains vitamin B6. Diclegis is a medication used for treating nausea as well as nausea during pregnancy. It can also be known as morning sickness. Diclegis can also be used to treat conditions that aren't listed in this guide.


Do not take Diclegis if you've taken an MAO inhibitor within the last 14 days, like linezolid, isocarboxazid or methylene blue injection, or phenelzine rasagiline and selegiline, as well as tranylcypromine.

Before you take this drug

Do not take Diclegis if you have taken an MAO inhibitor within the past 14 days. A potentially dangerous interaction with a drug could happen. MAO inhibitors include isocarboxazid linezolid, Methylene blue injection rasagiline, phenelzine, and tranylcypromine.

It is not recommended to use this medicine if you're allergic to pyridoxine, doxylamine, or different antihistamines like Benadryl or Dramamine.

Inform your doctor if you were ever diagnosed with:

  • Asthma or any other breathing disorders;
  • Glaucoma is an increase in pressure within your eye.
  • Obstruction in the stomach (stomach or the bowels);
  • A stomach ulcer or
  • Bladder obstruction, or other urinary issues.

Breastfeeding is not advised during the use of Diclegis. Diclegis is not a product that is approved for use by anyone less than 18 years of age.

How to take Diclegis?

Use Diclegis exactly as directed by your physician. Follow the instructions on the prescription label and go through all medication guides and instructions sheets. Make sure you use the medicine exactly as prescribed. Take Diclegis with your stomach empty and a cup of fluids. Diclegis is taken either at the time of bed or before bed and at the beginning of the day. Follow your doctor's instructions for dosing extremely carefully. Suck the capsule or tablet in its entirety, and don't crush, chew, or break it.

Contact your physician in the event that your symptoms don't improve or become more severe. Severe or ongoing vomiting can cause you to get dehydrated and cause serious medical issues. This medicine could alter the results of a urine test for drug screening and result in inaccurate results. Inform the laboratory personnel that you take Diclegis. Place it in a cool, dry place free of heat and moisture. Store the pills in the original container, and keep the packaging or canister of preservative that absorbs moisture.

Details on dosage

Usual Adult Dose for Nausea or Vomiting:

During Pregnancy:

2 tablets taken orally before sleep
Maximum dose: 4 tablets daily.

Comments: Take it daily, not on a regular basis.

What happens if I miss the dose?

Do not take the medicine for as long as you are able, but do not take any missed doses if it's close to the time of the next dose. Don't have two doses at one time.

Do not exceed 2 capsules or tablets within the span of 24 hours.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

The symptoms of an overdose can consist of dry mouth, severe tiredness, and dizziness, as well as confusion, a tense sensation, dilation of the pupils, fast heartbeats, seizures (convulsions), or muscle discomfort or weakness accompanied by a high fever and dark-colored urine.

What should be avoided?

Avoid driving and other hazardous activities until you are aware of the effects of this medication on your body. The way you react could be impaired. Beware of drinking alcohol. It may cause drowsiness. by Diclegis. Don't take any medication without consulting your physician if you are pregnant.

Side effects of Diclegis

Take immediate medical attention. If you are experiencing symptoms of an allergic reaction, Diclegis: hives and breathing problems or swelling of your lips, face, and tongue.

Common Diclegis side effects can be:

  • Drowiness

This isn't a complete list of possible side effects, and other effects may also be present. Consult your physician to seek medical advice on adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

The use of Diclegis along with other medicines that cause you to become drowsy could increase the severity of this effect. Talk to your doctor prior to using opioids, a sleeping pill, a muscle relaxer, or medication for anxiety, depression, or seizures.

Other medications may also impact Diclegis, such as medications that are prescribed and available over the counter, such as vitamins, prescriptions, and natural products. Discuss with your doctor all the medicines you are currently taking as well as any medications you are about to start or stop taking.