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Pronunciation: aw-VEHL-ah-tee
Name of the Generic: Bupropion and dextromethorphan
Dosage Format: Extended-release tablets
Classification of Drugs: Miscellaneous antidepressants

What is Auvelity?

Auvelity is a prescribed medicine that is used to treat a specific kind of depression referred to as major depressive disorder (MDD) in adults.It isn't known whether this medication is reliable and safe for use in children.

Auvelity has not been approved to be used for other purposes other than the treatment of MDD. The ingredients used in Auvelity, bupropion, dextromethorphan, and bupropion, are the same components that are in other medications that are approved for different uses.Auvelity could result in serious adverse reactions, including:

Greater risk of suicidal behaviors and thoughts. Auvelity and other antidepressant medications can increase suicidal thoughts and behaviors among some adolescents, children, and young adults, particularly in the initial few months of treatment or when the dosage is altered. Autism is not a suitable choice for children.

  • Mental illnesses and depression are the main motives behind suicidal ideas or actions.

  • What signs can I watch out for and prevent suicidal thoughts and behavior within my own family members or myself?

  • Be alert to sudden shifts in your conduct yourself, your mood or mood or if you have suicidal thoughts or actions.

    This is vital when you take an antidepressant medication, or when you are adjusting the dosage.

  • Inform your doctor as soon as possible to inform your doctor of any sudden or new changes in behavior, attitude or mood or if you're experiencing suicidal thoughts or behavior.

  • Follow-up visits to your doctor on time Contact your doctor during your visits, particularly if you have questions about your symptoms.

Contact your doctor or seek help for an emergency now if you notice any of the symptoms listed below, particularly if they're new, more severe, or bother you:

  • Thoughts of suicide or the idea of dying

  • New or more severe depression

  • Being extremely agitated, becoming restless,

  • Trouble sleeping (insomnia)

  • Attempt to commit suicide

  • New or worse anxiety

  • Panic attacks

  • New or more extreme new or worse

  • Being aggressive, angry, or acting violent

  • An extreme increase in talk and activity (mania)

  • Acting on dangerous impulses

  • Other unusual behavior changes or moods


Do not sign up for Auvelity if you are:

  • Have you had or experienced an epileptic disorder?

  • Have or have experienced an eating disorder, such as anorexia nervosa or bulimia or anorexia

  • You've quit drinking alcohol or using drugs known as barbiturates, benzodiazepines, or anti seizure drugs or anti seizure medicines, and then you've abruptly stopped taking these medications.

  • Take a monoamine oxidase inhibitor (MAOI).

  • Have quit using an MAOI within the past 14 days.

  • Patients are treated with the antibiotic linezolid or intravenous Methylene Blue.

  • Are sensitive to dextromethorphan, bupropion, or any other ingredient. Check out the bottom of this page to find a complete description of all the components.

Consult your physician or pharmacist if you are uncertain if you are taking an MAOI or one of these medications, such as the antibiotic linezolid or intravenous Methylene Blue.Do not begin Auvelity in the event that you have stopped taking an MAOI in the past 14 days.Do not take an MAOI for a minimum of 14 days following the end of the treatment using Auvelity.

Before You Take This Drug

Before you begin treatment, inform your physician about your medical condition and conditions, such as if:

  • Were afflicted with seizures or convulsions.

  • I have suffered an injury to the head.

  • Are suffering from an attack on their heart or heart issues.

  • You may have a tumor within the nerve system of your body (brain or spinal).

  • You may have suffered a stroke.

  • Are suffering from low blood sugar.

  • Have low levels of sodium in your blood?

  • Have liver issues

  • Are suffering from kidney issues.

  • You drink a lot of booze.

  • Abuse prescription medications or street drugs.

  • If you suffer from diabetes, use oral diabetes medications or insulin to regulate your blood sugar levels.

  • Have high blood pressure

  • Are prone to falls and have a history of them.

  • Are bipolar or suffer from bipolar disorder, or have an ancestral history of suicide, bipolar disorder, or depression.

  • Are prone to high pressure within the eyes (glaucoma).

  • You are expecting or planning to be pregnant. Auvelity could cause harm to your baby if you take it during your pregnancy. The use of Auvelity is not recommended during pregnancy.

    Inform your doctor right away if you find yourself pregnant or suspect you're pregnant while receiving treatment. Your doctor will recommend another treatment for women who are planning to get pregnant.

    The registry for pregnancy is for women in contact with Auvelity while pregnant. The aim of the registry is to gather details about the health of females who are exposed to autism and their infants. If you become pregnant during treatment, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visit online at programs/pregnancyregistry/antidepressants/.

  • If you are nursing or plan to, One of the components in Auvelity bupropion, which is the name of the drug, can pass into breast milk. Don't breastfeed while you are taking treatments with Auvelity or for five days after the dose that you received.

Interaction With Other Drugs

Inform your doctor about every medication you are taking, such as prescription and over-the-counter supplements as well as vitamins and herbal supplements.

Auvelity and a few other medications could interact with each other, which could result in dangerous adverse consequences. Auvelity could affect how other medicines work, and other medicines could alter the way Auvelity functions.

It is important to inform your physician that you're taking:

  • Other medications that contain bupropion or dextromethorphan

  • Drugs are used to treat mood disorders, anxiety, psychotic disorders, and thought disorders, such as selective serotonin receptor inhibitors (SSRIs).

  • Tricyclic antidepressants

  • Theophylline

  • Corticosteroids

  • Oral diabetes medication or insulin to regulate your blood sugar levels

  • Medicine to curb appetite (anorectic)

  • Nicotine-related medicines that can aid you in quitting smoking cigarettes

  • Street (illicit) illicit drugs

  • Benzodiazepines, sedative-hypnotics (sleep medicines),opiates

  • CNS stimulants

Consult your doctor for advice if you're not certain whether you're having any issues with these drugs. Your doctor can inform you whether it is suitable to consume Auvelity alongside other medications.

Do not begin or stop taking any other medication in the course of treatment without consulting your doctor first. The abrupt stoppage of treatment could result in severe adverse effects. Read more about

the Auvelity side effects

.Take note of the medicines you are taking. Keep a list to show your doctor and pharmacist whenever you are prescribed an upcoming medicine.

How to Take Auvelity?

  • Take Auvelity exactly as your physician advises you to.

  • Suckle the Auvelity tablets completely. Don't crush, chew, or split the tablets.

  • Auvelity is a drink that can be taken in combination with or even without

  • Use Auvelity one time per day for three days, after which you can increase your dosage to twice a day (taken at least 8 hours apart).

  • Do not exceed two Auvelity tablets in a 24-hour period.

  • If you do not take a dose, don't take a second dose in order to compensate for the dose you skipped. Take each dose according to the normal schedule. Don't take more than one dosage of Auvelity at a time.

  • If you've taken large quantities or overdosed If you're experiencing an poisoning or overdose, you should contact the poison control centre at 1-800-222-1222, or visit your nearest emergency room

    at the hospital immediately.

Details On Dosage

Usual Adult Dose for Autism

A tablet every day in the morning for 3 days, then increase the dosage to the maximum dosage recommended of one tablet twice a day, separated by a minimum of 8 hours.Each extended-release tablet contains dextromethorphan hydrobromide, 45 mg, and bupropion hydrochloride, 105 mg.

Comment: Prior to initiation of treatment with Auvelity, check blood pressure and check patients for signs of bipolar disorder, manic depression, or hypomania. Also, determine whether patients are taking other medicines that contain bupropion and dextromethorphan.Treatment of major depression (MDD) in adults

What Should be Avoided?

  • Reduce or stop using alcohol while you are in treatment. If you typically consume alcohol regularly, consult your physician prior to suddenly abstaining. If you quit drinking alcohol, you could increase your risk of experiencing seizures.

  • Don't drive a vehicle or operate heavy machinery until you are aware of the extent to which Auvelity impacts you. Autism may hinder your ability to perform these things in a safe manner.

Side Effects Of Auvelity

Auvelity could result in serious adverse side effects that include:Check out the important



seizures. There is a chance of developing seizures when you treat autism with Auvelity. The risk is greater for those who:

  • You should take higher doses. Auvelity

  • Are afflicted by certain medical issues.

  • Use Auvelity together with certain other medications.

You should not take Auvelity alongside other medications unless your doctor advises you to.

If you experience an epileptic seizure while you are taking treatment, discontinue taking Auvelity and contact your doctor immediately. Don't take Auvelity again when you experience seizures.

The increase in blood pressure (hypertension) Some patients may develop high blood pressure while receiving treatment. Your healthcare provider should test your blood pressure prior to beginning treatment and also during treatment.The manic episode Manic episodes may occur in bipolar disorder patients taking Auvelity. The symptoms could include:

  • Significantly enhanced energy

  • Racing thoughts

  • Remarkable, brilliant ideas

  • Talking faster or faster than normal

  • Severe trouble sleeping

  • Irresponsible behavior

  • Extreme happiness or irritation

Unusual thoughts or behavior. One of the ingredients in Auvelity (bupropion) can cause strange thoughts or behaviors that include illusions (believing that you're another person), hallucinations (seeing or hearing things that aren't visible), paranoia (feeling that others are in opposition to you), or feeling overwhelmed. If this occurs to you, contact your doctor.

Eye issues (angle-closure glaucoma) Auvelity may cause a specific eye issue called angle closure or glaucoma in people suffering from other eye diseases. It is possible to have an eye exam to determine whether you're at risk of developing the condition and seek an eye exam and treatment to prevent it. Consult your physician if you experience eye pain, changes in your vision, swelling, or redness around your eyes.dizziness. Auvelity may cause dizziness, which can increase the risk of falling.

Serotonin Syndrome. A potentially life-threatening issue known as serotonin syndrome can occur when you use Auvelity together with other medicines. Consult your physician or visit the nearest hospital emergency room as soon as you can when you notice one of these signs or symptoms of serotonin syndrome.

  • Afraidation

  • Hearing or seeing things that aren't present (hallucinations)

  • Confusion

  • Coma

  • Fast heartbeat

  • Changes in blood pressure

  • Dizziness

  • Sweating

  • Flushing

  • Elevated temperatures in the body (hyperthermia).

  • Shaking (tremors), rigid muscles, or moving

  • Loss of coordination

  • Seizures

  • Nausea, vomiting, and diarrhea

The most frequent adverse effects are:

  • Dizziness

  • Diarrhea

  • Dry mouth

  • Excessive sweating

  • Headache

  • Feeling tired

  • Sexual function issues

There are many possible adverse consequences. Contact your doctor to get medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.